Point-of-care testing (POCT) diagnostic systems using microfluidic lab-on-a-chip technologies

2015 ◽  
Vol 132 ◽  
pp. 46-57 ◽  
Author(s):  
Wooseok Jung ◽  
Jungyoup Han ◽  
Jin-Woo Choi ◽  
Chong H. Ahn
Keyword(s):  
Point Of Care ◽  
Lab On A Chip ◽  
Diagnostic Systems ◽  
Point Of Care Testing

scholarly journals Elasto-Magnetic Pumps Integrated within Microfluidic Devices

2021 ◽  
Vol 4 (1) ◽  
pp. 48
Author(s):  
Jacob L. Binsley ◽  
Elizabeth L. Martin ◽  
Thomas O. Myers ◽  
Stefano Pagliara ◽  
Feodor Y. Ogrin
Keyword(s):  
Magnetic System ◽  
Point Of Care ◽  
Microfluidic Channel ◽  
Lab On A Chip ◽  
Microfluidic Devices ◽  
Point Of Care Testing ◽  
Ongoing Research ◽  
Flow Rates ◽  
Pumping System ◽  
Oscillating Magnetic Field

Many lab-on-a-chip devices require a connection to an external pumping system in order to perform their function. While this is not problematic in typical laboratory environments, it is not always practical when applied to point-of-care testing, which is best utilized outside of the laboratory. Therefore, there has been a large amount of ongoing research into producing integrated microfluidic components capable of generating effective fluid flow from on-board the device. This research aims to introduce a system that can produce practical flow rates, and be easily fabricated and actuated using readily available techniques and materials. We show how an asymmetric elasto-magnetic system, inspired by Purcell’s three-link swimmer, can provide this solution through the generation of non-reciprocal motion in an enclosed environment. The device is fabricated monolithically within a microfluidic channel at the time of manufacture, and is actuated using a weak, oscillating magnetic field. The flow rate can be altered dynamically, and the direction of the resultant flow can be controlled by adjusting the frequency of the driving field. The device has been proven, experimentally and numerically, to operate effectively when applied to fluids with a range of viscosities. Such a device may be able to replace external pumping systems in portable applications.

scholarly journals Proceedings of the First Workshop on Standards for Microfluidics

2019 ◽  
Vol 124 ◽  
Author(s):  
Darwin R. Reyes ◽  
Henne van Heeren
Keyword(s):  
Point Of Care ◽  
Lab On A Chip ◽  
In Vitro Diagnostics ◽  
Point Of Care Testing ◽  
Future Developments ◽  
Exciting Opportunity ◽  
Micro Total Analysis Systems ◽  
Advance Research ◽  
Total Analysis

In the last two decades, the microfluidics/lab-on-a-chip field has evolved from the concept of micro total analysis systems, where systems with integrated pretreatment and analysis of chemicals were envisioned, to what is known today as lab-on-a-chip, which is expected to be modular. This field has shown great potential for the development of technologies that can make, and to some extent are making, a big difference in areas such as in vitro diagnostics, point of care testing, organ on a chip, and many more. Microfluidics plays an essential role in these systems, and determining the standards needed in this area is critical for enabling new markets and products, and to advance research and development. Our goal was to bring together stakeholders from industry, academia, and government to discuss and define the needs within the field for the development of standards. This publication contains a summary of the workshop, abstracts from each presentation, and a summary of the breakout sessions from the National Institute of Standards and Technology Workshop on Standards for Microfluidics, held on June 1–2, 2017. The workshop was attended by 46 persons from 26 organizations and 11 countries. This was a unique and exciting opportunity for stakeholders from all over the world to join in the discussion of future developments towards standardization in the microfluidics arena.

Development of functional lab-on-a-chip on polymer for point-of-care testing of metabolic parameters

Lab on a Chip ◽  
2008 ◽  
Vol 8 (12) ◽  
pp. 2113 ◽  
Author(s):  
Jaephil Do ◽  
Sehwan Lee ◽  
Jungyup Han ◽  
Junhai Kai ◽  
Chien-Chong Hong ◽  
...  
Keyword(s):  
Point Of Care ◽  
Lab On A Chip ◽  
Metabolic Parameters ◽  
Point Of Care Testing

scholarly journals Quantum Dots: An Emerging Tool for Point-of-Care Testing

Micromachines ◽  
2020 ◽  
Vol 11 (12) ◽  
pp. 1058
Author(s):  
Suchita Singh ◽  
Aksha Dhawan ◽  
Sonali Karhana ◽  
Madhusudan Bhat ◽  
Amit Kumar Dinda
Keyword(s):  
Quantum Dots ◽  
Biomedical Applications ◽  
Bulk Material ◽  
Point Of Care ◽  
Diagnostic Systems ◽  
Point Of Care Testing ◽  
Size Dependent ◽  
Semiconductor Crystals ◽  
Optical And Electronic Properties ◽  
Narrow Emission

Quantum dots (QDs) are semiconductor crystals in the nanodimension having unique optical and electronic properties that differ from bulk material due to quantum mechanics. The QDs have a narrow emission peak, size-dependent emission wavelength, and broad excitation range which can be utilized for diverse biomedical applications such as molecular imaging, biosensing, and diagnostic systems. This article reviews the current developments of biomedical applications of QDs with special reference to point-of-care testing.

scholarly journals Polymer microfluidic devices: an overview of fabrication methods

2017 ◽  
Vol 1 (1) ◽  
pp. 67-79 ◽  
Author(s):  
Raquel O. Rodrigues ◽  
Rui Lima ◽  
Helder T. Gomes ◽  
Adrián M. T. Silva
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Lab On A Chip ◽  
Microfluidic Devices ◽  
Point Of Care Testing ◽  
Standard Methods ◽  
Time Consumption ◽  
Advantages And Disadvantages ◽  
Fundamental Research ◽  
Microfabrication Techniques

The amount of applications associated with microfluidic devices is increasing since the introduction of Lab-on-a-chip devices in the 1990s, especially regarding biomedical and clinical fields. However, in order for this technology to leave the fundamental research and become a day-life technology (e.g., as point-of-care testing), it needs to be disposable and reasonably less expensive. Polymers, due to their several advantages, such as easier microfabrication and low-cost, fill these needs. Several methods are reported regarding microfabrication and, thus, the main aim of the present work is to provide an overview of the most relevant microfabrication techniques found in literature employing polymers, clarifying also the main advantages and disadvantages of each technique and especially considering their cost and time-consumption. Moreover, a future outlook of low-cost microfabrication techniques and standard methods is provided.

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