AluYb8 insertion in the MUTYH gene is related to increased 8-OHdG in genomic DNA and could be a risk factor for type 2 diabetes in a Chinese population

2011 ◽  
Vol 332 (1-2) ◽  
pp. 301-305 ◽  
Author(s):  
Huimei Chen ◽  
Caixia Sun ◽  
Wenwen Guo ◽  
Ran Meng ◽  
Hong Du ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Risk Factor ◽  
Chinese Population ◽  
Genomic Dna ◽  
Mutyh Gene

scholarly journals Elevation of PTPN1 promoter methylation is a significant risk factor of type 2 diabetes in the Chinese population

2017 ◽  
Vol 14 (4) ◽  
pp. 2976-2982 ◽  
Author(s):  
Qing Huang ◽  
Liyuan Han ◽  
Yanfen Liu ◽  
Changyi Wang ◽  
Donghui Duan ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Risk Factor ◽  
Promoter Methylation ◽  
Chinese Population ◽  
Significant Risk ◽  
Significant Risk Factor

The BMI and skeletal muscle mass as a risk factor of carotid atherosclerosis in patients with type 2 diabetes

2018 ◽  
Author(s):  
Se-Hwa Kim ◽  
Soo-Kyung Kim ◽  
Young-Ju Choi ◽  
Seok-Won Park ◽  
Eun-Jig Lee ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Skeletal Muscle ◽  
Risk Factor ◽  
Muscle Mass ◽  
Skeletal Muscle Mass ◽  
Carotid Atherosclerosis

278-LB: Type 2 Diabetes (T2D) as a Risk Factor for NASH and Significant Liver Fibrosis (F>2) in an International Cohort of 2,363 Patients with Metabolic Steatosis

Diabetes ◽  
2019 ◽  
Vol 68 (Supplement 1) ◽  
pp. 278-LB
Author(s):  
BART STAELS ◽  
VLAD RATZIU ◽  
ARUN J. SANYAL ◽  
SVEN FRANCQUE ◽  
STEPHEN A. HARRISON ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Risk Factor ◽  
Liver Fibrosis ◽  
Significant Liver Fibrosis

Correlation of Waist to Calf Circumference Ratio and Carotid Intima Media Thickness in Diabetes Mellitus

2020 ◽  
Vol 16 ◽  
Author(s):  
Harish A Rao ◽  
Prakash Harischandra ◽  
Srikanth Yadav
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Carotid Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Calf Circumference ◽  
Media Thickness

Introduction: Diabetes mellitus is a well-known risk factor for cardiovascular disease, because of the accelerated process of atherosclerosis. Obesity is an established risk factor and has gained immense importance in recent studies as an important risk factor for clinical cardiovascular disease, yet the fundamental component stays unclear. Calf circumference is another form for lean mass and peripheral subcutaneous fat and is inversely associated with occurrence of carotid plaques (CP). Multiplicative and opposite effects of both Calf Circumference (CC) and Waist Circumference (WC) in event of CP suggest that the two measures should be taken into account commonly while assessing vascular risk profile. Aim & Objective: To ascertain if waist to calf circumference ratio (WCR) is a marker of Carotid atherosclerosis in patients with type 2 diabetes mellitus. To asses s the correlation between waist to calf circumference ratio and carotid intima media thickness (CIMT ) in patients with Type 2 diabetes. Materials and methods: A cross sectional study at Hospital affiliated to Kasturba Medical college Mangalore from Sept 2016 to Sept 2018 . Method of study: Patients with type 2 DM as per ADA criteria, age >18years are recruited for the study. Results and discussion: In our study with 150 population 25 patients had carotid atherosclerosis and 20 patients had CIMT>1.1. The waist circumference in patients with CA is in the range of 93.07 and 99.85 & the CC in patients with CA is in the range of 29.49 to 31.25. The WCR in patients with CA is in the range of 3.12 to 3.26. The difference was statistically significant with a p value of <0.05. In our study it was found that WC and WCR correlated well with carotid atherosclerosis, and surprisingly calf circumference also correlated with carotid atherosclerosis but not as significant as both WC and WCR. Conclusion: To conclude, in our population based study of 150 subjects we found that carotid atherosclerosis is significantly more in people with increased waist calf circumference ratio. WCR may be a new, useful and practical anthropometric index that facilitates the early identification of diabetic subjects with high risk for cardiovascular disease. Validation of this finding in individual populations is required. Future studies should test the association of calf circumference with carotid intima media thickness and carotid plaques using better measures than ultrasound such as magnetic resonance imaging. Further research focusing on underlying mechanisms in the role of lean mass and peripheral fat mass is required.

High levels of organochlorine pesticides in drinking water as a risk factor for type 2 diabetes: A study in north India

2021 ◽  
Vol 271 ◽  
pp. 116287
Author(s):  
Shipra Tyagi ◽  
Manushi Siddarth ◽  
Brijesh Kumar Mishra ◽  
Basu Dev Banerjee ◽  
Abdul Jamil Urfi ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Drinking Water ◽  
Risk Factor ◽  
Organochlorine Pesticides ◽  
North India

scholarly journals Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes

Diagnostics ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 145
Author(s):  
Nurruzanna Ismail ◽  
Noraidatulakma Abdullah ◽  
Nor Azian Abdul Murad ◽  
Rahman Jamal ◽  
Siti Aishah Sulaiman
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Disease Progression ◽  
Biological Fluids ◽  
Specific Cell ◽  
New Paradigm ◽  
Diagnostic Potential ◽  
Non Coding Rnas

The discovery of non-coding RNAs (ncRNAs) has opened a new paradigm to use ncRNAs as biomarkers to detect disease progression. Long non-coding RNAs (lncRNA) have garnered the most attention due to their specific cell-origin and their existence in biological fluids. Type 2 diabetes patients will develop cardiovascular disease (CVD) complications, and CVD remains the top risk factor for mortality. Understanding the lncRNA roles in T2D and CVD conditions will allow the future use of lncRNAs to detect CVD complications before the symptoms appear. This review aimed to discuss the roles of lncRNAs in T2D and CVD conditions and their diagnostic potential as molecular biomarkers for CVD complications in T2D.

Sign in / Sign up

Export Citation Format

Share Document