scholarly journals Long Non-Coding RNAs (lncRNAs) in Cardiovascular Disease Complication of Type 2 Diabetes

Diagnostics ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 145
Author(s):  
Nurruzanna Ismail ◽  
Noraidatulakma Abdullah ◽  
Nor Azian Abdul Murad ◽  
Rahman Jamal ◽  
Siti Aishah Sulaiman
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Disease Progression ◽  
Biological Fluids ◽  
Specific Cell ◽  
New Paradigm ◽  
Diagnostic Potential ◽  
Non Coding Rnas

The discovery of non-coding RNAs (ncRNAs) has opened a new paradigm to use ncRNAs as biomarkers to detect disease progression. Long non-coding RNAs (lncRNA) have garnered the most attention due to their specific cell-origin and their existence in biological fluids. Type 2 diabetes patients will develop cardiovascular disease (CVD) complications, and CVD remains the top risk factor for mortality. Understanding the lncRNA roles in T2D and CVD conditions will allow the future use of lncRNAs to detect CVD complications before the symptoms appear. This review aimed to discuss the roles of lncRNAs in T2D and CVD conditions and their diagnostic potential as molecular biomarkers for CVD complications in T2D.

Correlation of Waist to Calf Circumference Ratio and Carotid Intima Media Thickness in Diabetes Mellitus

2020 ◽  
Vol 16 ◽  
Author(s):  
Harish A Rao ◽  
Prakash Harischandra ◽  
Srikanth Yadav
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Carotid Atherosclerosis ◽  
Intima Media Thickness ◽  
Carotid Intima Media Thickness ◽  
Calf Circumference ◽  
Media Thickness

Introduction: Diabetes mellitus is a well-known risk factor for cardiovascular disease, because of the accelerated process of atherosclerosis. Obesity is an established risk factor and has gained immense importance in recent studies as an important risk factor for clinical cardiovascular disease, yet the fundamental component stays unclear. Calf circumference is another form for lean mass and peripheral subcutaneous fat and is inversely associated with occurrence of carotid plaques (CP). Multiplicative and opposite effects of both Calf Circumference (CC) and Waist Circumference (WC) in event of CP suggest that the two measures should be taken into account commonly while assessing vascular risk profile. Aim & Objective: To ascertain if waist to calf circumference ratio (WCR) is a marker of Carotid atherosclerosis in patients with type 2 diabetes mellitus. To asses s the correlation between waist to calf circumference ratio and carotid intima media thickness (CIMT ) in patients with Type 2 diabetes. Materials and methods: A cross sectional study at Hospital affiliated to Kasturba Medical college Mangalore from Sept 2016 to Sept 2018 . Method of study: Patients with type 2 DM as per ADA criteria, age >18years are recruited for the study. Results and discussion: In our study with 150 population 25 patients had carotid atherosclerosis and 20 patients had CIMT>1.1. The waist circumference in patients with CA is in the range of 93.07 and 99.85 & the CC in patients with CA is in the range of 29.49 to 31.25. The WCR in patients with CA is in the range of 3.12 to 3.26. The difference was statistically significant with a p value of <0.05. In our study it was found that WC and WCR correlated well with carotid atherosclerosis, and surprisingly calf circumference also correlated with carotid atherosclerosis but not as significant as both WC and WCR. Conclusion: To conclude, in our population based study of 150 subjects we found that carotid atherosclerosis is significantly more in people with increased waist calf circumference ratio. WCR may be a new, useful and practical anthropometric index that facilitates the early identification of diabetic subjects with high risk for cardiovascular disease. Validation of this finding in individual populations is required. Future studies should test the association of calf circumference with carotid intima media thickness and carotid plaques using better measures than ultrasound such as magnetic resonance imaging. Further research focusing on underlying mechanisms in the role of lean mass and peripheral fat mass is required.

Limited benefit of haemoglobin glycation index as risk factor for cardiovascular disease in type 2 diabetes patients

2019 ◽  
Vol 45 (3) ◽  
pp. 254-260 ◽  
Author(s):  
H.B. Østergaard ◽  
T. Mandrup-Poulsen ◽  
G.F.N. Berkelmans ◽  
Y. van der Graaf ◽  
F.L.J. Visseren ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Diabetes Patients

scholarly journals Plasma Level of Urate among Sudanese with Type 2 Diabetes in Khartoum state, Sudan.

2014 ◽  
Vol 2 (12) ◽  
pp. 24-29
Author(s):  
Salma Hussein Elhassan ◽  
Bader Eldien Hassan Elabid ◽  
Sara osman Yousif
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Type 2 Diabetes Mellitus ◽  
Risk Factor ◽  
Plasma Level ◽  
Lipid Profile ◽  
Diabetic Patients ◽  
Plasma Urate

Background: Type 2 diabetes mellitus is an independent risk factor for cardiovascular disease and the risk for cardiovascular disease is increased three to four fold in type 2 diabetes mellitus as compared to non-diabetic population. Hyperuricaemia has been reported to be a potential risk factor for cardiovascular disease in type 2 diabetes mellitus. The objective of this study was to assess the plasma level of urate in Sudanese patients with type 2 diabetes in comparison with apparently healthy (non-diabetic) volunteers as controls.Methods: This is a descriptive, cross- sectional and hospital-based study conducted during the period from March to May 2011 in Jabir Abu Elez diabetic center and Nurein medical center, both in Khartoum state, Sudan. The study group included 52 NIDDM cases and 30 healthy controls of either sex matched for age and gender. Fasting venous samples were collected from both cases and controls. Serum levels of uric acid, and lipid profile were assayed using commercial reagent kits from Biosystem Company.Results: In the current study there was a significant increase in plasma urate in type 2 diabetic patients as compared to the control group. There was a significant increase in lipid profile with exception to high density lipoprotein which was significantly reduced. There was insignificant correlation of plasma urea, and lipid profile with both; body mass index and the duration of diabetes.Conclusion: Hyperuricemia is significantly associated with type 2 diabetes mellitus and can increase the morbidity and mortality of diabetes if not managed in time. Elevated plasma urate levels are associated with increased risk of cardiovascular mortality in type 2 diabetes.

scholarly journals Cardiovascular Disease Incidence and Risk Factor Patterns among Omanis with Type 2 Diabetes: A Retrospective Cohort Study

2017 ◽  
Vol 32 (2) ◽  
pp. 106-114 ◽  
Author(s):  
Abdul Hakeem Al Rawahi ◽  
Patricia Lee ◽  
Zaher A.M. Al Anqoudi ◽  
Ahmed Al Busaidi ◽  
Muna Al Rabaani ◽  
...  
Keyword(s):  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Cohort Study ◽  
Retrospective Cohort Study ◽  
Retrospective Cohort ◽  
Disease Incidence ◽  
Cardiovascular Disease Incidence

Insulin resistance: an additional risk factor in the pathogenesis of cardiovascular disease in type 2 diabetes

2015 ◽  
Vol 21 (1) ◽  
pp. 11-23 ◽  
Author(s):  
Tushar P. Patel ◽  
Komal Rawal ◽  
Ashim K. Bagchi ◽  
Gauri Akolkar ◽  
Nathalia Bernardes ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Risk Factor ◽  
Additional Risk Factor ◽  
Additional Risk

scholarly journals HbA1c is a risk factor for cardiovascular disease in association with oxidative stress in patients with type 2 diabetes mellitus

2017 ◽  
Vol 5 (7) ◽  
pp. 3114 ◽  
Author(s):  
Siva Prasad Palem
Keyword(s):  
Oxidative Stress ◽  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Cardiovascular Disease ◽  
Type 2 Diabetes Mellitus ◽  
Risk Factor ◽  
Healthy Controls ◽  
High Level ◽  
Type 2 Diabetic

Background: Cardiovascular disease (CVD) is a major cause of death in diabetic subjects. Glycaemic status is one of the vital factor involved in vascular complications. It was clear the effect of glycaemia on microvascular complications, but uncertain on macrovascular complications. As we know oxidative stress plays a major role in the development of atherosclerosis and cardiovascular disease. Since oxidative stress is a risk factor for cardiovascular disease, the study has designed to perceive an association between HbA1c and oxidative stress in patients with type 2 diabetes mellitus for early prediction of cardiovascular events.Methods: 120 subjects were taken into the study, among these 60 type 2 diabetic subjects and remaining 60 subjects were healthy controls. The parameters like HbA1c, MDA and FRAP were estimated by established methods. ‘Kruskal Wallis’ test was used for variables in the parameters and Pearson correlation test was used to perform correlation between HbA1c and oxidative stress.Results: High level of HbA1c and MDA, low level of FRAP were found in patients with type 2 diabetes than healthy controls. The study was also found HbA1c have positive association with malondialdehyde (MDA) and negative association with FRAP.Conclusions: HbA1c was positively associated with oxidative stress in patients with type 2 diabetes mellitus. In this scenario, type 2 diabetic patients with high level of HbA1c might have risk of cardiovascular events.

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