Acupuncture for the management of menopausal and perimenopausal symptoms: Current clinical evidence and perspectives for future research

Maturitas ◽  
2017 ◽  
Vol 100 ◽  
pp. 82-83 ◽  
Author(s):  
Tae-Hun Kim ◽  
Myeong Soo Lee ◽  
Terje Alraek
Keyword(s):  
Clinical Evidence ◽  
Future Research ◽  
Perimenopausal Symptoms

scholarly journals Ginseng and Anticancer Drug Combination to Improve Cancer Chemotherapy: A Critical Review

2014 ◽  
Vol 2014 ◽  
pp. 1-13 ◽  
Author(s):  
Shihong Chen ◽  
Zhijun Wang ◽  
Ying Huang ◽  
Stephen A. O'Barr ◽  
Rebecca A. Wong ◽  
...  
Keyword(s):  
Anticancer Drugs ◽  
Animal Studies ◽  
Clinical Evidence ◽  
Chinese Literature ◽  
Good Evidence ◽  
Future Research ◽  
Objective Evidence ◽  
Wide Usage

Ginseng, a well-known herb, is often used in combination with anticancer drugs to enhance chemotherapy. Its wide usage as well as many documentations are often cited to support its clinical benefit of such combination therapy. However the literature based on objective evidence to make such recommendation is still lacking. The present review critically evaluated relevant studies reported in English and Chinese literature on such combination. Based on our review, we found good evidence fromin vitroandin vivoanimal studies showing enhanced antitumor effect when ginseng is used in combination with some anticancer drugs. However, there is insufficient clinical evidence of such benefit as very few clinical studies are available. Future research should focus on clinically relevant studies of such combination to validate the utility of ginseng in cancer.

scholarly journals Breast Cancer Risk with Progestin Subdermal Implants: A Challenge in Patients Counseling

2021 ◽  
Vol 12 ◽  
Author(s):  
Ghada Mohammed ◽  
Noha A. Mousa ◽  
Iman M. Talaat ◽  
Haya Ibrahim ◽  
Maha Saber-Ayad
Keyword(s):  
Potential Role ◽  
Clinical Evidence ◽  
Potential Effect ◽  
Current Evidence ◽  
Future Research ◽  
Patient Counseling ◽  
Research Directions ◽  
Future Research Directions ◽  
Subdermal Implants

There is a steady global rise in the use of progestin subdermal implants, where use has increased by more than 20 times in the past two decades. BC risk has been reported with the older progestin only methods such as oral pills, injectables, and intrauterine devices, however, little is known about the risk with subdermal implants. In this review, we aim to update clinicians and researchers on the current evidence to support patient counseling and to inform future research directions. The available evidence of the association between the use of progestin subdermal implants and BC risk is discussed. We provide an overview of the potential role of endogenous progesterone in BC development. The chemical structure and molecular targets of synthetic progestins of relevance are summarized together with the preclinical and clinical evidence on their association with BC risk. We review all studies that investigated the action of the specific progestins included in subdermal implants. As well, we discuss the potential effect of the use of subdermal implants in women at increased BC risk, including carriers of BC susceptibility genetic mutations.

Application of Blood Purification to Non-Renal Organ Failure

2005 ◽  
Vol 28 (5) ◽  
pp. 445-449 ◽  
Author(s):  
J.A. Kellum ◽  
R. Venkataraman
Keyword(s):  
Organ Failure ◽  
Clinical Evidence ◽  
Multiple Organ ◽  
Blood Purification ◽  
Artificial Organs ◽  
Future Research ◽  
Challenges And Opportunities ◽  
Organ Failures ◽  
The Many ◽  
Improve Patient

The application of artificial organs to the task of blood purification in the setting of non-renal organ failure simultaneously presents important challenges and opportunities. Failures of cardiovascular, hepatic, coagulation and immune systems are all characterized by dysregulation leading to multi-organ failure. When sustained, these conditions result in multiple organ system dysfunction and death and are far too common in modern intensive care units (ICUs). While the pathogenesis of each of these organ failures is complex and variable, brought about by a variety of underlying conditions, the potential to improve patient outcomes by simultaneously targeting multiple pathways can perhaps best be realized by blood purification. Unlike drug strategies, which are usually limited to one component of these complex networks, blood purification is, by its very nature, broad spectrum and self regulating. For example, as the concentration of mediators or toxins increases, so does removal. Furthermore, given the many failed trials of specific therapy, the recent focus of immunomodulatory therapy in sepsis has shifted to non-specific methods of influencing the entire inflammatory response without suppressing it. In this issue of the journal, members of the Acute Dialysis Quality Initiative (ADQI) present systematic reviews on the application of hemofiltration, ultrafiltration, plasma therapies and liver-assist therapy for the treatment of non-renal organ failure. The focus of these reviews is on clinical evidence as well as recommendations for future research.

scholarly journals Let Food Be Thy Medicine—Its Role in Crohn’s Disease

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 832
Author(s):  
Judith Wellens ◽  
Séverine Vermeire ◽  
João Sabino
Keyword(s):  
Crohn’S Disease ◽  
Crohn's Disease ◽  
Enteral Nutrition ◽  
Clinical Evidence ◽  
Future Research ◽  
Novel Therapies ◽  
Exclusive Enteral Nutrition ◽  
Term Management ◽  
Paediatric Crohn’S Disease

The food we eat is thought to play a role in both the increasing incidence as well as the course of Crohn’s disease. What to eat and what to avoid is an increasingly important question for both patients and physicians. Restrictive diets are widely adopted by patients and carry the risk of inducing or worsening malnutrition, without any guarantees on anti-inflammatory potential. Nevertheless, exploration of novel therapies to improve long-term management of the disease is desperately needed and the widespread use of exclusive enteral nutrition in the induction of paediatric Crohn’s disease makes us wonder if a similar approach would be beneficial in adult patients. This narrative review discusses the current clinical evidence on whole food diets in achieving symptomatic and inflammatory control in Crohn’s disease and identifies knowledge gaps with areas for future research.

scholarly journals PTCOG Head and Neck Subcommittee Consensus Guidelines on Particle Therapy for the Management of Head and Neck Tumors

2021 ◽  
Vol 8 (1) ◽  
pp. 84-94
Author(s):  
Alexander Lin ◽  
John H. C. Chang ◽  
Ryan S. Grover ◽  
Frank J. P. Hoebers ◽  
Upendra Parvathaneni ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Side Effects ◽  
Head And Neck ◽  
Neck Cancer ◽  
Proton Therapy ◽  
Clinical Evidence ◽  
Particle Therapy ◽  
Future Research ◽  
Consensus Guidelines ◽  
Normal Tissues

Abstract Purpose: Radiation therapy is a standard modality in the treatment for cancers of the head and neck, but is associated with significant short- and long-term side effects. Proton therapy, with its unique physical characteristics, can deliver less dose to normal tissues, resulting in fewer side effects. Proton therapy is currently being used for the treatment of head and neck cancer, with increasing clinical evidence supporting its use. However, barriers to wider adoption include access, cost, and the need for higher-level evidence. Methods: The clinical evidence for the use of proton therapy in the treatment of head and neck cancer are reviewed here, including indications, advantages, and challenges. Results: The Particle Therapy Cooperative Group Head and Neck Subcommittee task group provides consensus guidelines for the use of proton therapy for head and neck cancer. Conclusion: This report can be used as a guide for clinical use, to understand clinical trials, and to inform future research efforts.

scholarly journals Emerging views of statin pleiotropy and cholesterol lowering

2021 ◽  
Author(s):  
Dongbo Yu ◽  
James K Liao
Keyword(s):  
Cardiovascular Health ◽  
Clinical Evidence ◽  
Lipid Lowering ◽  
Future Research ◽  
Cardiovascular Risk Reduction ◽  
Research Directions ◽  
Reductase Inhibitors ◽  
Clinical Benefits ◽  
Future Research Directions ◽  
Lipid Lowering Agents

Abstract Over the past four decades, no class of drugs has had more impact on cardiovascular health than the 3-hydroxy-methylglutaryl coenzyme A reductase inhibitors or statins. Developed as potent lipid-lowering agents, statins were later shown to reduce morbidity and mortality of patients who are at risk for cardiovascular disease. However, retrospective analyses of some of these clinical trials have uncovered some aspects of their clinical benefits that may be additional to their lipid-lowering effects. Such ‘pleiotropic’ effects of statins garnered intense interest and debate over its contribution to cardiovascular risk reduction. This review will provide a brief background of statin pleiotropy, assess the available clinical evidence for and against their non-lipid-lowering benefits, and propose future research directions in this field.

Serotonin syndrome with SSRIs augmentation of amisulpride: Two case report and literature review

2017 ◽  
Vol 41 (S1) ◽  
pp. S700-S700
Author(s):  
M. Preve ◽  
A. Ruccia ◽  
R. Traber ◽  
R.A. Colombo
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Serotonin Syndrome ◽  
Clinical Evidence ◽  
Antidepressant Drugs ◽  
Future Research ◽  
Research Directions ◽  
Quantitative Studies ◽  
Future Research Directions ◽  
Competing Interest

IntroductionSerotonin syndrome is a potential adverse reaction to drugs increasing serotoninergic activity in the nervous system, some of them being frequently prescribed, such as antidepressant drugs. The association of myoclonus, diarrhea, confusion, hypomania, agitation, hyperreflexia, shivering, in-coordination, fever and diaphoresis, when patients are treated with serotoninergic agents, could constitute a “serotonin syndrome”. The purpose of this report is to review the clinical evidence of serotonin syndrome with SSRIs augmentation of amisulpride. We propose two case report and literature review.MethodWe conducted a systematic review of the literature with the principal database (PubMed, Enbase, PsychInfo) and we present two case report [1,2].ResultsWe describe two different case report with SSRIs augmentation of amisulpride.Discussion and conclusionTo our knowledge this is no report about the emergence of serotonin syndrome due to the use of SSRIs augmentation of amisulpride. Serotonin syndrome symptoms include high body temperature, agitation, increased reflexes, tremor, sweating, fever, dilated pupils, and diarrhea. Further research is warranted to replicate our clinical and qualitative observations and, in general, quantitative studies in large samples followed up over time are needed. Methodological limitations, clinical implications and suggestions for future research directions are considered.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Clinical Utility of Extracorporeal Cytokine Hemoadsorption Therapy: A Literature Review

2018 ◽  
Vol 46 (4) ◽  
pp. 337-349 ◽  
Author(s):  
Anthony Bonavia ◽  
Andrew Groff ◽  
Kunal Karamchandani ◽  
Kai Singbartl
Keyword(s):  
Clinical Utility ◽  
Clinical Evidence ◽  
Critical Role ◽  
Disease Process ◽  
Emerging Technology ◽  
Future Research ◽  
High Morbidity ◽  
Normal Pattern ◽  
Novel Technology ◽  
Sepsis And Septic Shock

Cytokines play a critical role in coordinating and amplifying a host immune response to infection. The normal pattern of localized and systemic release of proinflammatory and anti-inflammatory cytokines varies on the basis of the disease process. A dysregulated cytokine response can lead to a hyper-inflammatory condition called a cytokine storm. This is believed to contribute to the pathophysiology of sepsis and septic shock, a condition carrying high morbidity and mortality in critically ill patients. Extracorporeal cytokine hemoadsorption is an emerging technology utilized in the treatment of dysregulated inflammatory states such as sepsis, although there is a paucity of clinical evidence supporting its outcomes benefits. We assess the peer-reviewed literature relating to cytokine hemoadsorption in the context of sepsis and suggest areas of future research incorporating this novel technology.

Paramethoxymethamphetamine (Mitsubishi turbo) abuse: Case report and literature review

2017 ◽  
Vol 41 (S1) ◽  
pp. s875-s875
Author(s):  
M. Preve ◽  
N.E. Suardi ◽  
M. Godio ◽  
R. Traber ◽  
R.A. Colombo
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Clinical Evidence ◽  
Future Research ◽  
Research Directions ◽  
Quantitative Studies ◽  
Psychomotor Activation ◽  
Paranoid Delusion ◽  
Future Research Directions ◽  
Competing Interest

IntroductionParamethoxymethamphetamine and paramethoxyamphetamine (PMMA and PMA) are two so-called designer amphetamines, which appear from time to time on the illegal narcotics market in many countries. They are frequently sold as ecstasy or amphetamine, often mixed with amphetamine or methamphetamine [1, 2]. Paramethoxyamphetamine (PMA) is a hallucinogenic synthetic substituted amphetamine with capable of development of dependence [3]. The purpose of this report is to review the clinical evidence for the potential of abuse of paramethoxyamphetamine. We propouse a case report and literature review.MethodWe conducted a systematic review of the literature with the principal database (PubMed, Enbase, PsychInfo) and we present a case report.ResultsThe effects of paramethoxyamphetamine is characterized at the beginning with symptoms like euphoria, derealizzation, psychomotor activation, feeling in tune with surroundings and in love for friends, who come to visual and auditory illusions and hallucinations, paranoid delusion, and violent agitation.Discussion and conclusionThe use of these recreational drugs is especially common among young people participating in rave parties. Occasionally paramethoxymethamphetamine (PMMA) or paramethoxyamphetamine (PMA) are found in street drugs offered as ecstasy. Further research is warranted to replicate our clinical and qualitative observations and, in general, quantitative studies in large samples followed up over time are needed. Methodological limitations, clinical implications and suggestions for future research directions are considered.Disclosure of interestThe authors have not supplied their declaration of competing interest.

scholarly journals Is Curcumin the Answer to Future Chemotherapy Cocktail?

Molecules ◽  
2021 ◽  
Vol 26 (14) ◽  
pp. 4329
Author(s):  
Wei Yang Kong ◽  
Siew Ching Ngai ◽  
Bey Hing Goh ◽  
Learn-Han Lee ◽  
Thet Thet Htar ◽  
...  
Keyword(s):  
Combination Therapy ◽  
Clinical Evidence ◽  
Research Direction ◽  
Future Research ◽  
Cancer Therapies ◽  
Combination Treatments ◽  
Anticancer Effects ◽  
Critical Insight ◽  
New Cancer Therapies ◽  
Continuous Use

The rise in cancer cases in recent years is an alarming situation worldwide. Despite the tremendous research and invention of new cancer therapies, the clinical outcomes are not always reassuring. Cancer cells could develop several evasive mechanisms for their survivability and render therapeutic failure. The continuous use of conventional cancer therapies leads to chemoresistance, and a higher dose of treatment results in even greater toxicities among cancer patients. Therefore, the search for an alternative treatment modality is crucial to break this viscous cycle. This paper explores the suitability of curcumin combination treatment with other cancer therapies to curb cancer growth. We provide a critical insight to the mechanisms of action of curcumin, its role in combination therapy in various cancers, along with the molecular targets involved. Curcumin combination treatments were found to enhance anticancer effects, mediated by the multitargeting of several signalling pathways by curcumin and the co-administered cancer therapies. The preclinical and clinical evidence in curcumin combination therapy is critically analysed, and the future research direction of curcumin combination therapy is discussed.

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