Fractional CO2 laser treatment for atrophic vaginitis in breast cancer patients using aromatase inhibitors

Maturitas ◽  
2015 ◽  
Vol 81 (1) ◽  
pp. 159-160 ◽  
Author(s):  
Aurelie Joris ◽  
Serge Rozenberg
Keyword(s):  
Breast Cancer ◽  
Cancer Patients ◽  
Laser Treatment ◽  
Aromatase Inhibitors ◽  
Co2 Laser ◽  
Breast Cancer Patients ◽  
Fractional Co2 Laser ◽  
Atrophic Vaginitis ◽  
Co2 Laser Treatment

scholarly journals Early Regenerative Modifications of Human Postmenopausal Atrophic Vaginal Mucosa Following Fractional CO2 Laser Treatment

2018 ◽  
Vol 6 (1) ◽  
pp. 6-14 ◽  
Author(s):  
Stefano Salvatore ◽  
Katlein França ◽  
Torello Lotti ◽  
Marta Parma ◽  
Sonia Palmieri ◽  
...  
Keyword(s):  
Connective Tissue ◽  
Laser Treatment ◽  
Co2 Laser ◽  
Vaginal Mucosa ◽  
Structural Components ◽  
Related Factors ◽  
Fractional Co2 Laser ◽  
Collagen Iii ◽  
Co2 Laser Treatment ◽  
Stimulation Of

BACKGROUND: Postmenopausal women experience undesired symptoms that adversely affect their quality of life. In the recent years, a specific 12 - week fractional CO2 laser treatment has been introduced, with highly significant relief of symptoms.AIM: The aim of this paper is the identification of the early modifications of structural components of atrophic vaginal mucosa induced by laser irradiation, which is responsible for the restorative processes.MATERIAL AND METHODS: We investigated by microscopical, ultrastructural and biochemical methods the modifications of the structural components of postmenopausal atrophic vaginal mucosa tissues after 1 hour following a single fractional laser CO2 application.RESULTS: In one hour, the mucosal epithelium thickens, with the maturation of epithelial cells and desquamation at the epithelial surface. In the connective tissue, new papillae indenting the epithelium with newly formed vessels penetrating them, new thin fibrils of collagen III are also formed in a renewed turnover of components due to the increase of metalloproteinase - 2. Specific features of fibroblasts support stimulation of their activity responsible of the renewal of the extracellular matrix, with an increase of mechanical support as connective tissue and stimulation of growth and maturation to epithelium thanks to new vessels and related factors delivered.CONCLUSION: We found the activation of regenerative mechanisms expressed both in the connective tissue - with the formation of new vessels, new papillae, and new collagen - and in the epithelium with the associated thickening and desquamation of cells at the mucosal surface.

T2 Fractional CO2 Laser Treatment Outcomes for Pediatric Hypertrophic Burn Scars

2019 ◽  
Vol 40 (Supplement_1) ◽  
pp. S2-S3
Author(s):  
S P Patel ◽  
H Nguyen ◽  
D Mannschreck ◽  
R J Redett ◽  
K B Puttgen ◽  
...  
Keyword(s):  
Treatment Outcomes ◽  
Laser Treatment ◽  
Co2 Laser ◽  
Fractional Co2 Laser ◽  
Co2 Laser Treatment

scholarly journals Assessment of cardiotoxicity in hormone positive postmenopausal breast cancer patients receiving aromatase inhibitors

2019 ◽  
Vol 9 (1) ◽  
pp. 11
Author(s):  
Reham M. Faheim ◽  
Eman A. El-Shaarawy ◽  
Dina A. Salem ◽  
Rehab G. Shaaban
Keyword(s):  
Breast Cancer ◽  
Blood Pressure ◽  
Lipid Profile ◽  
Cancer Patients ◽  
Aromatase Inhibitors ◽  
Hormone Receptor ◽  
Postmenopausal Breast Cancer ◽  
P Value ◽  
Breast Cancer Patients ◽  
Hormone Receptor Positive

Background: Aromatase inhibitors (AIs) represent an effective endocrine treatment for hormone receptor-positive postmenopausal breast cancer patients with early stage or metastatic disease.Objective: Assessment of Cardiotoxicity in Hormone positive Postmenopausal Breast Cancer Patients receiving AIs (upfront orswitch therapy).Methods: This cross sectional study included 123 postmenopausal breast cancer patients presented to the Clinical Oncology Department, Ain Shams University (Cairo, Egypt) in the interval from August 2016 to June 2017 with hormone receptor positive receiving Aromatase Inhibitors, To assess cardiotoxicity in these patients, they were subjected to blood pressure and lipid profile measurement, electrocardiography (ECG), and electrocardiography (ECHO) and classified into patients had Nolvadex then A.I (arm 1) and others had upfront A.I (arm 2).Results: The age of patients ranged from 41 years to 85 years with mean age of 61 years. Seventy one patients (57.7%) showed cardiotoxicity as assessed by ECHO. They showed significant correlation with rising age above 62 years, IHD, history of HTN and DM (p value: .001, .001, .017 and 0.035 respectively). However, correlation between cardiotoxity and blood pressure changes, lipid profile changes and ECG findings and ECHO changes in switch therapy and upfront A.I were not statistically significant (p value = .275, .116, .081 and .761 respectively).Conclusion: Assessment of cardiotoxicity in hormone positive postmenopausal breast cancer patients receiving Aromatase Inhibitors showed evidence of cardiotoxicity in half the patients (57.7%) as detected by ECHO only. They showed statistically non significant correlations either recievied switch therapy or upfront A.I.

Fractional CO2 laser treatment for burn scar improvement: A systematic review and meta-analysis

Burns ◽  
2020 ◽  
Author(s):  
Katherine J. Choi ◽  
Eva A. Williams ◽  
Christopher H. Pham ◽  
Zachary J. Collier ◽  
Justin Dang ◽  
...  
Keyword(s):  
Systematic Review ◽  
Laser Treatment ◽  
Co2 Laser ◽  
Meta Analysis ◽  
Burn Scar ◽  
Fractional Co2 Laser ◽  
Co2 Laser Treatment
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