Curculigo orchioides, a traditional Chinese medicinal plant, prevents bone loss in ovariectomized rats

Maturitas ◽  
2008 ◽  
Vol 59 (4) ◽  
pp. 373-380 ◽  
Author(s):  
D.P. Cao ◽  
Y.N. Zheng ◽  
L.P. Qin ◽  
T. Han ◽  
H. Zhang ◽  
...  
Keyword(s):  
Bone Loss ◽  
Medicinal Plant ◽  
Ovariectomized Rats ◽  
Curculigo Orchioides ◽  
Chinese Medicinal Plant

Effects of some Chinese medicinal plant extracts on five different fungi

Food Control ◽  
2007 ◽  
Vol 18 (12) ◽  
pp. 1547-1554 ◽  
Author(s):  
Sheng-Hsien Lee ◽  
Ku-Shang Chang ◽  
Min-Sheng Su ◽  
Yung-Sheng Huang ◽  
Hung-Der Jang
Keyword(s):  
Medicinal Plant ◽  
Plant Extracts ◽  
Medicinal Plant Extracts ◽  
Chinese Medicinal Plant

scholarly journals Combination treatment with pioglitazone and fenofibrate attenuates pioglitazone-mediated acceleration of bone loss in ovariectomized rats

2011 ◽  
Vol 212 (2) ◽  
pp. 179-186 ◽  
Author(s):  
Rana Samadfam ◽  
Malaika Awori ◽  
Agnes Bénardeau ◽  
Frieder Bauss ◽  
Elena Sebokova ◽  
...  
Keyword(s):  
Bone Loss ◽  
Bone Mass ◽  
Trabecular Bone ◽  
Bone Mineral ◽  
Combination Treatment ◽  
Mass Gain ◽  
Ovariectomized Rats ◽  
Concomitant Treatment ◽  
Mineral Density ◽  
Ovx Rats

Peroxisome proliferator-activated receptor (PPAR) γ agonists, such as pioglitazone (Pio), improve glycemia and lipid profile but are associated with bone loss and fracture risk. Data regarding bone effects of PPARα agonists (including fenofibrate (Feno)) are limited, although animal studies suggest that Feno may increase bone mass. This study investigated the effects of a 13-week oral combination treatment with Pio (10 mg/kg per day)+Feno (25 mg/kg per day) on body composition and bone mass parameters compared with Pio or Feno alone in adult ovariectomized (OVX) rats, with a 4-week bone depletion period, followed by a 6-week treatment-free period. Treatment of OVX rats with Pio+Feno resulted in ∼50% lower fat mass gain compared with Pio treatment alone. Combination treatment with Pio+Feno partially prevented Pio-induced loss of bone mineral content (∼45%) and bone mineral density (BMD; ∼60%) at the lumbar spine. Similar effects of treatments were observed at the femur, most notably at sites rich in trabecular bone. At the proximal tibial metaphysis, concomitant treatment with Pio+Feno prevented Pio exacerbation of ovariectomy-induced loss of trabecular bone, resulting in BMD values in the Pio+Feno group comparable to OVX controls. Discontinuation of Pio or Feno treatment of OVX rats was associated with partial reversal of effects on bone loss or bone mass gain, respectively, while values in the Pio+Feno group remained comparable to OVX controls. These data suggest that concurrent/dual agonism of PPARγ and PPARα may reduce the negative effects of PPARγ agonism on bone mass.

scholarly journals The Protective Effect of Rhizoma Dioscoreae Extract against Alveolar Bone Loss in Ovariectomized Rats via Regulating Wnt and p38 MAPK Signaling

Nutrients ◽  
2014 ◽  
Vol 6 (12) ◽  
pp. 5853-5870 ◽  
Author(s):  
Zhiguo Zhang ◽  
Lihua Xiang ◽  
Dong Bai ◽  
Wenlai Wang ◽  
Yan Li ◽  
...  
Keyword(s):  
Bone Loss ◽  
Protective Effect ◽  
P38 Mapk ◽  
Alveolar Bone ◽  
Mapk Signaling ◽  
Alveolar Bone Loss ◽  
Ovariectomized Rats

Alpha-Lipoic Acid Promotes Osteoblastic Formation in H2 O2 -Treated MC3T3-E1 Cells and Prevents Bone Loss in Ovariectomized Rats

2015 ◽  
Vol 230 (9) ◽  
pp. 2184-2201 ◽  
Author(s):  
Chao Fu ◽  
Dong Xu ◽  
Chang-Yuan Wang ◽  
Yue Jin ◽  
Qi Liu ◽  
...  
Keyword(s):  
Bone Loss ◽  
Lipoic Acid ◽  
Ovariectomized Rats ◽  
Alpha Lipoic Acid

scholarly journals Whey Protein Concentrate Hydrolysate Prevents Bone Loss in Ovariectomized Rats

2015 ◽  
Vol 18 (12) ◽  
pp. 1349-1356 ◽  
Author(s):  
Jonggun Kim ◽  
Hyung Kwan Kim ◽  
Saehun Kim ◽  
Ji-Young Imm ◽  
Kwang-Youn Whang
Keyword(s):  
Bone Loss ◽  
Whey Protein ◽  
Ovariectomized Rats ◽  
Whey Protein Concentrate ◽  
Protein Concentrate

Intra-Articular Injection of a Nanosuspension of Tetramethylpyrazine Dihydroxynaphthalenate for Stronger and Longer-Lasting Effects Against Osteoarthritis

2021 ◽  
Vol 17 (6) ◽  
pp. 1199-1207
Author(s):  
Hanmei Li ◽  
Hongyi Zhuo ◽  
Dan Yin ◽  
Wei Li ◽  
Yamei Zhang ◽  
...  
Keyword(s):  
Particle Size ◽  
Medicinal Plant ◽  
Treatment Effect ◽  
Retention Time ◽  
Therapeutic Efficacy ◽  
Ion Pairing ◽  
Systemic Toxicity ◽  
Joint Cavity ◽  
Hydrophobic Ion Pairing ◽  
Chinese Medicinal Plant

Tetramethylpyrazine (TMP), isolated from the rhizome of the traditional Chinese medicinal plant Chuanxiong (Ligusticum wallichii Franchat) shows therapeutic efficacy against osteoarthritis. After intra-articular injection, the retention time of TMP in the joint cavity is short, which limits its treatment effect. To avoid this problem, the present study explored the preparation of a TMP nanosuspension (TMP-NS) based on hydrophobic ion pairing. TMP-NS showed a particle size of approximately 588 nm and, after intra-articular injection in rats, it had longer retention in the articular cavity, higher TMP concentrations in joints, and greater anti-osteoarthritic efficacy than TMP solution. TMP-NS didn’t cause significant inflammation at the joint. These results suggest that TMP-NS may strengthen and prolong the therapeutic efficacy of TMP against osteoarthritis without systemic toxicity.

Molecular Authentication of the Traditional Chinese Medicinal Plant Euphorbia pekinensis

Planta Medica ◽  
2006 ◽  
Vol 73 (01) ◽  
pp. 91-93 ◽  
Author(s):  
Heng-Gang Xue ◽  
Song-Dong Zhou ◽  
Xing-Jin He ◽  
Yan Yu
Keyword(s):  
Medicinal Plant ◽  
Molecular Authentication ◽  
Chinese Medicinal Plant
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