Doxycycline-regulated over-expression of hsp22 has negative effects on stress resistance and life span in adult Drosophila melanogaster

2004 ◽  
Vol 125 (9) ◽  
pp. 651-663 ◽  
Author(s):  
Deepak Bhole ◽  
Michael J. Allikian ◽  
John Tower
Keyword(s):  
Drosophila Melanogaster ◽  
Life Span ◽  
Stress Resistance ◽  
Negative Effects ◽  
Over Expression ◽  
Adult Drosophila

scholarly journals Neuronal Expression of p53 Dominant-Negative Proteins in Adult Drosophila melanogaster Extends Life Span

2005 ◽  
Vol 15 (22) ◽  
pp. 2063-2068 ◽  
Author(s):  
Johannes H. Bauer ◽  
Peter C. Poon ◽  
Heather Glatt-Deeley ◽  
John M. Abrams ◽  
Stephen L. Helfand
Keyword(s):  
Drosophila Melanogaster ◽  
Life Span ◽  
Dominant Negative ◽  
Neuronal Expression ◽  
Adult Drosophila

The effects of pectins on life span and stress resistance in Drosophila melanogaster

2013 ◽  
Vol 15 (2) ◽  
pp. 113-127 ◽  
Author(s):  
Mikhail Shaposhnikov ◽  
Dmitrii Latkin ◽  
Ekaterina Plyusnina ◽  
Lyubov Shilova ◽  
Anton Danilov ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Life Span ◽  
Stress Resistance

scholarly journals Influense of curcumin on lifespan if it is applied at the larval stage of drosophila melanogaster

2020 ◽  
pp. 89-96
Author(s):  
Anatoly Pisaruk ◽  
Natalya Koshel ◽  
Ludmila Mekhova ◽  
Oksana Zabuga ◽  
Stephen Ivanov
Keyword(s):  
Drosophila Melanogaster ◽  
Life Span ◽  
Developmental Stage ◽  
Larval Stage ◽  
Developmental Duration ◽  
Larval Stages ◽  
Epigenetic Programming ◽  
Males And Females ◽  
Adult Drosophila ◽  
Different Doses

In this study we have applied the different doses of curcumin at the larval stages of a fruitfly Drosophila melanogaster and subsequently ivestigated its effect on the developmental duration and life expectancy of imago. It has been shown a 2-day delay in the hatching of the flies, which were developing in the medium containing 500 mM of curcumin. Exposure to curcumin significantly influenced on the average and maximum lifespan (ALS and MLS respectively) of all Drosofila in the study: ALS – F=13.01, p<0.001 for males and F=14.3, p<0.001 for females; MLS – F=35.9, p<0.001 for males and F=16.7, p <0.001 for females. Thus, the ALS in the males, which at the larval stage were kept in the medium containing 125 mM, 250 mM and 500 mM of curcumin, was significantly higher (p<0.001) comparing to the control. In females, such kind of significant increase in ALS has been shown at a dose of 500 mM of curcumin (p<0.001) in the medium during the developmental stage comparing to the control. In other words, the ALS of the imago has increased in correlation to the increase in the dose of curcumin applied at the developmental stage in males by 9%, 16%, 13%, and 23% and in females by 0%, 1%, 3%, 16% respectively. There has been also shown the sharp raise in MLS in both males and females, which at the larval stage were kept in the medium containing more than 125 mM of curcumin. To sum up we can assume that in this study consumption of curcumin at the larval stage of fruit flies significantly increased the developmental duration and life span of adult Drosophila, and this may demonstrate the effect of curcumin on the epigenetic programming of pace of life. Keywords: Development; Life span; Curcumin; Drosophila

scholarly journals Biotin deficiency decreases life span and fertility but increases stress resistance in Drosophila melanogaster

2004 ◽  
Vol 15 (10) ◽  
pp. 591-600 ◽  
Author(s):  
Anette Landenberger ◽  
Hadise Kabil ◽  
Lawrence G. Harshman ◽  
Janos Zempleni
Keyword(s):  
Drosophila Melanogaster ◽  
Life Span ◽  
Stress Resistance ◽  
Biotin Deficiency

Sexual Dimorphism in the Effect of a Taurine Supplemented Diet on Life Span in Adult Drosophila melanogaster

2010 ◽  
Vol 7 (1) ◽  
pp. 34-48 ◽  
Author(s):  
L.A. Smith ◽  
I. Habib ◽  
S. Shirkey ◽  
B. Talon ◽  
A. Milne ◽  
...  
Keyword(s):  
Drosophila Melanogaster ◽  
Sexual Dimorphism ◽  
Life Span ◽  
Adult Drosophila

Induced Overexpression of Mitochondrial Mn-Superoxide Dismutase Extends the Life Span of Adult Drosophila melanogaster

Genetics ◽  
2002 ◽  
Vol 161 (2) ◽  
pp. 661-672
Author(s):  
Jingtao Sun ◽  
Donna Folk ◽  
Timothy J Bradley ◽  
John Tower
Keyword(s):  
Drosophila Melanogaster ◽  
Life Span ◽  
Adult Life ◽  
Heat Pulse ◽  
Maximum Life Span ◽  
Adult Life Span ◽  
Flp Recombinase ◽  
Transgenic Lines ◽  
Added Benefit ◽  
Adult Drosophila

Abstract A transgenic system (“FLP-out”) based on yeast FLP recombinase allowed induced overexpression of MnSOD enzyme in adult Drosophila melanogaster. With FLP-out a brief heat pulse (HP) of young, adult flies triggered the rearrangement and subsequent expression of a MnSOD transgene throughout the adult life span. Control (no HP) and overexpressing (HP) flies had identical genetic backgrounds. The amount of MnSOD enzyme overexpression achieved varied among six independent transgenic lines, with increases up to 75%. Life span was increased in proportion to the increase in enzyme. Mean life span was increased by an average of 16%, with some lines showing 30-33% increases. Maximum life span was increased by an average of 15%, with one line showing as much as 37% increase. Simultaneous overexpression of catalase with MnSOD had no added benefit, consistent with previous observations that catalase is present in excess in the adult fly with regard to life span. Cu/ZnSOD overexpression also increases mean and maximum life span. For both MnSOD and Cu/ZnSOD lines, increased life span was not associated with decreased metabolic activity, as measured by O2 consumption.

Extension of life span and stress resistance of Drosophila melanogaster by long-term supplementation with melatonin

2002 ◽  
Vol 37 (5) ◽  
pp. 629-638 ◽  
Author(s):  
Ernesto Bonilla ◽  
Shirley Medina-Leendertz ◽  
Solangel Dı́az
Keyword(s):  
Drosophila Melanogaster ◽  
Life Span ◽  
Stress Resistance
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