Effects of simultaneous over-expression of Cu/ZnSOD and MnSOD on Drosophila melanogaster life span

2004 ◽  
Vol 125 (5) ◽  
pp. 341-349 ◽  
Author(s):  
Jingtao Sun ◽  
John Molitor ◽  
John Tower
Keyword(s):  
Drosophila Melanogaster ◽  
Life Span ◽  
Over Expression

scholarly journals Over-expression of the catalytic core of mitochondrial DNA (mtDNA) polymerase in the nervous system of Drosophila melanogaster reduces median life span by inducing mtDNA depletion

2008 ◽  
Vol 105 (1) ◽  
pp. 165-176 ◽  
Author(s):  
Francisco Martínez-Azorín ◽  
Manuel Calleja ◽  
Rosana Hernández-Sierra ◽  
Carol L. Farr ◽  
Laurie S. Kaguni ◽  
...  
Keyword(s):  
Nervous System ◽  
Mitochondrial Dna ◽  
Drosophila Melanogaster ◽  
Life Span ◽  
Catalytic Core ◽  
Over Expression ◽  
Mtdna Depletion

scholarly journals Neuronal Expression of p53 Dominant-Negative Proteins in Adult Drosophila melanogaster Extends Life Span

2005 ◽  
Vol 15 (22) ◽  
pp. 2063-2068 ◽  
Author(s):  
Johannes H. Bauer ◽  
Peter C. Poon ◽  
Heather Glatt-Deeley ◽  
John M. Abrams ◽  
Stephen L. Helfand
Keyword(s):  
Drosophila Melanogaster ◽  
Life Span ◽  
Dominant Negative ◽  
Neuronal Expression ◽  
Adult Drosophila

scholarly journals Monoassociation withLactobacillus plantarumDisrupts Intestinal Homeostasis in AdultDrosophila melanogaster

mBio ◽  
2018 ◽  
Vol 9 (4) ◽  
Author(s):  
David Fast ◽  
Aashna Duggal ◽  
Edan Foley
Keyword(s):  
Drosophila Melanogaster ◽  
Stem Cell ◽  
Simple Model ◽  
Life Span ◽  
Lactobacillus Plantarum ◽  
Adult Longevity ◽  
Intestinal Homeostasis ◽  
Content Type ◽  
Cell Divisions ◽  
Stem Cell Divisions

ABSTRACTAdultDrosophila melanogasterraised in the absence of symbiotic bacteria have fewer intestinal stem cell divisions and a longer life span than their conventionally reared counterparts. However, we do not know if increased stem cell divisions are essential for symbiont-dependent regulation of longevity. To determine if individual symbionts cause aging-dependent death inDrosophila, we examined the impacts of common symbionts on host longevity. We found that monoassociation of adultDrosophilawithLactobacillus plantarum, a widely reported fly symbiont and member of the probioticLactobacillusgenus, curtails adult longevity relative to germfree counterparts. The effects ofLactobacillus plantarumon life span were independent of intestinal aging. Instead, we found that association withLactobacillus plantarumcauses an extensive intestinal pathology within the host, characterized by loss of stem cells, impaired epithelial renewal, and a gradual erosion of epithelial ultrastructure. Our study uncovers an unknown aspect ofLactobacillus plantarum-Drosophilainteractions and establishes a simple model to characterize symbiont-dependent disruption of intestinal homeostasis.IMPORTANCEUnder homeostatic conditions, gut bacteria provide molecular signals that support the organization and function of the host intestine. Sudden shifts in the composition or distribution of gut bacterial communities impact host receipt of bacterial cues and disrupt tightly regulated homeostatic networks. We used theDrosophila melanogastermodel to determine the effects of prominent fly symbionts on host longevity and intestinal homeostasis. We found that monoassociation withLactobacillus plantarumleads to a loss of intestinal progenitor cells, impaired epithelial renewal, and disruption of gut architecture as flies age. These observations uncover a novel phenotype caused by monoassociation of a germfree host with a common symbiont and establish a simple model to characterize symbiont-dependent loss of intestinal homeostasis.

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