Carbonic anhydrase IX expression is associated with tumor progression and a poor prognosis of lung adenocarcinoma

Lung Cancer ◽  
2006 ◽  
Vol 54 (3) ◽  
pp. 409-418 ◽  
Author(s):  
Hidehiro Kon-no ◽  
Genichiro Ishii ◽  
Kanji Nagai ◽  
Junji Yoshida ◽  
Mitsuyo Nishimura ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Lung Adenocarcinoma ◽  
Tumor Progression ◽  
Poor Prognosis ◽  
Carbonic Anhydrase Ix

scholarly journals Carbonic Anhydrase IX as a Marker for Poor Prognosis in Soft Tissue Sarcoma

2004 ◽  
Vol 10 (13) ◽  
pp. 4464-4471 ◽  
Author(s):  
Kårstein Måseide ◽  
Rita A. Kandel ◽  
Robert S. Bell ◽  
Charles N. Catton ◽  
Brian O’Sullivan ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Carbonic Anhydrase ◽  
Poor Prognosis ◽  
Carbonic Anhydrase Ix

scholarly journals Prognostic significance of carbonic anhydrase IX expression by cancer-associated fibroblasts in lung adenocarcinoma

Cancer ◽  
2009 ◽  
Vol 115 (12) ◽  
pp. 2732-2743 ◽  
Author(s):  
Masayuki Nakao ◽  
Genichiro Ishii ◽  
Kanji Nagai ◽  
Akikazu Kawase ◽  
Hirotsugu Kenmotsu ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Lung Adenocarcinoma ◽  
Prognostic Significance ◽  
Carbonic Anhydrase Ix ◽  
Cancer Associated Fibroblasts

scholarly journals Carbonic anhydrase IX enhances tumor cell proliferation and tumor progression in osteosarcoma

2018 ◽  
Vol Volume 11 ◽  
pp. 6879-6886 ◽  
Author(s):  
Kazuma Okuno ◽  
Takao Matsubara ◽  
Tomoki Nakamura ◽  
Takahiro Iino ◽  
Takuya Kakimoto ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Carbonic Anhydrase ◽  
Tumor Cell ◽  
Tumor Progression ◽  
Carbonic Anhydrase Ix ◽  
Tumor Cell Proliferation

Paip1 predicts poor prognosis and promotes tumor progression through AKT/GSK-3β pathway in lung adenocarcinoma

2019 ◽  
Vol 86 ◽  
pp. 233-242 ◽  
Author(s):  
Yixuan Wang ◽  
Junjie Piao ◽  
Qianrong Wang ◽  
Xuelian Cui ◽  
Ziqi Meng ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Tumor Progression ◽  
Poor Prognosis ◽  
Gsk 3Β

Overexpression of carbonic anhydrase IX (CAIX) in vulvar cancer is associated with tumor progression and development of locoregional lymph node metastases

2010 ◽  
Vol 456 (5) ◽  
pp. 483-490 ◽  
Author(s):  
Matthias Choschzick ◽  
Linn Woelber ◽  
Stephan Hess ◽  
Christine zu Eulenburg ◽  
Jörg Schwarz ◽  
...  
Keyword(s):  
Lymph Node ◽  
Carbonic Anhydrase ◽  
Tumor Progression ◽  
Lymph Node Metastases ◽  
Vulvar Cancer ◽  
Carbonic Anhydrase Ix ◽  
Node Metastases ◽  
Locoregional Lymph Node

scholarly journals Carbonic anhydrase IX: a regulator of pH and participant in carcinogenesis

2021 ◽  
pp. jclinpath-2020-207073
Author(s):  
Alessandro Pietro Aldera ◽  
Dhirendra Govender
Keyword(s):  
Renal Cell Carcinoma ◽  
Carbonic Anhydrase ◽  
Cell Carcinoma ◽  
Small Molecule ◽  
Renal Cell ◽  
Poor Prognosis ◽  
Small Molecule Inhibitors ◽  
Clear Cell ◽  
Carbonic Anhydrase Ix ◽  
Solid Organ

Carbonic anhydrase IX (CAIX) is a transmembrane metalloenzyme which is upregulated in tumour cells under hypoxic conditions. CAIX expression is induced by the accumulation of hypoxia-inducible factor-1α and has several downstream effects, including acidification of the extracellular pH, loss of cellular adhesion and increased tumour cell migration. CAIX is upregulated in a variety of solid organ tumours and has prognostic implications. High CAIX protein expression is a marker of poor prognosis in breast, lung, ovarian and bladder carcinomas. Conversely, low expression is an indicator of poor prognosis in clear cell renal cell carcinoma (CCRCC). CAIX immunohistochemistry is useful diagnostically to identify metastatic CCRCC, and the recently recognised clear cell papillary renal cell carcinoma. There is much interest in targeting CAIX with monoclonal antibodies and small molecule inhibitors. There are several small molecule inhibitors under development which have shown promising results in clinical trials. In this paper, we provide an overview of the role of CAIX in tumourigenesis and outline its use as a prognostic, diagnostic and therapeutic biomarker.

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