scholarly journals Prognostic significance of carbonic anhydrase IX expression by cancer-associated fibroblasts in lung adenocarcinoma

Cancer ◽  
2009 ◽  
Vol 115 (12) ◽  
pp. 2732-2743 ◽  
Author(s):  
Masayuki Nakao ◽  
Genichiro Ishii ◽  
Kanji Nagai ◽  
Akikazu Kawase ◽  
Hirotsugu Kenmotsu ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Lung Adenocarcinoma ◽  
Prognostic Significance ◽  
Carbonic Anhydrase Ix ◽  
Cancer Associated Fibroblasts

Prognostic Significance of a Novel Hypoxia-Regulated Marker, Carbonic Anhydrase IX, in Invasive Breast Carcinoma

2001 ◽  
Vol 19 (16) ◽  
pp. 3660-3668 ◽  
Author(s):  
Stephen K. Chia ◽  
Charles C. Wykoff ◽  
Peter H. Watson ◽  
Cheng Han ◽  
Russell D. Leek ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Overall Survival ◽  
Breast Carcinoma ◽  
Carbonic Anhydrase ◽  
Invasive Breast Cancer ◽  
Estrogen Receptor Status ◽  
Prognostic Significance ◽  
Invasive Breast Carcinoma ◽  
Carbonic Anhydrase Ix ◽  
Ca Ix

PURPOSE: To assess the frequency of expression and the prognostic significance of a hypoxia-regulated marker, carbonic anhydrase IX (CA IX), in a cohort of patients with invasive breast cancer. PATIENTS AND METHODS: CA IX expression was evaluated by immunohistochemistry with a murine monoclonal antibody, M75, in a series of 103 women treated surgically for invasive breast cancer. The majority of patients were treated with adjuvant hormonal or chemotherapy. The frequency of CA IX expression, its association with recognized prognostic factors, and the relationship with outcome was evaluated by univariate and multivariate statistical analyses. RESULTS: CA IX expression was present in 49 (48%) of 103 cases. The level of CA IX expression was found to be significantly associated with tumor necrosis (P < .001), higher grade (P = .02), and negative estrogen receptor status (P < .001). Furthermore, CA IX expression was associated with a higher relapse rate (P = .004) and a worse overall survival (P = .001). By multivariate analysis, CA IX was also shown to be an independent predictive factor for overall survival (hazard ratio, 2.61; 95% confidence interval, 1.01 to 6.75, P = .05). CONCLUSION: CA IX expression was associated with worse relapse-free survival and overall survival in an unselected cohort of patients with invasive breast carcinoma. The potential role of CA IX as a marker of hypoxia within breast carcinomas was also indicated by a significant association with necrosis. Further work assessing its prognostic significance in breast cancer is warranted, particularly interactions with radiotherapy and chemotherapy resistance.

Prognostic significance of combining immunohistochemical markers for cancer-associated fibroblasts in lung adenocarcinoma tissue

2019 ◽  
Vol 475 (2) ◽  
pp. 181-189
Author(s):  
Chihiro Inoue ◽  
Daisuke Tamatsuki ◽  
Yasuhiro Miki ◽  
Ryoko Saito ◽  
Yoshinori Okada ◽  
...  
Keyword(s):  
Lung Adenocarcinoma ◽  
Prognostic Significance ◽  
Cancer Associated Fibroblasts ◽  
Immunohistochemical Markers

Prognostic significance of carbonic anhydrase IX (CAIX), endoglin (CD105), and 8-hydroxy-2deoxyguanosine (8-OHdG) in breast cancer patients.

2010 ◽  
Vol 28 (15_suppl) ◽  
pp. e21048-e21048
Author(s):  
L. Beketic-Oreskovic ◽  
P. Ozretic ◽  
Z. N. Rabbani ◽  
I. L. Jackson ◽  
B. Sarcevic ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Carbonic Anhydrase ◽  
Cancer Patients ◽  
Prognostic Significance ◽  
Carbonic Anhydrase Ix ◽  
Breast Cancer Patients

770 poster PROGNOSTIC SIGNIFICANCE OF CARBONIC ANHYDRASE IX (CA IX) IN BREAST CANCER PATIENTS TREATED WITH RADIOTHERAPY

2011 ◽  
Vol 99 ◽  
pp. S303-S304
Author(s):  
L. Beketic-Oreskovic ◽  
P. Ozretic ◽  
Z. Rabbani ◽  
I. Jackson ◽  
B. Sarcevic ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Carbonic Anhydrase ◽  
Cancer Patients ◽  
Prognostic Significance ◽  
Carbonic Anhydrase Ix ◽  
Breast Cancer Patients ◽  
Ca Ix

scholarly journals Carbonic anhydrase IX from cancer-associated fibroblasts drives epithelial-mesenchymal transition in prostate carcinoma cells

Cell Cycle ◽  
2013 ◽  
Vol 12 (11) ◽  
pp. 1791-1801 ◽  
Author(s):  
Tania Fiaschi ◽  
Elisa Giannoni ◽  
Letizia Taddei ◽  
Paolo Cirri ◽  
Alberto Marini ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Prostate Carcinoma ◽  
Epithelial Mesenchymal Transition ◽  
Carcinoma Cells ◽  
Carbonic Anhydrase Ix ◽  
Cancer Associated Fibroblasts ◽  
Mesenchymal Transition

Prognostic Significance of Carbonic Anhydrase IX (CA-IX), Endoglin (CD105) and 8-hydroxy-2′-deoxyguanosine (8-OHdG) in Breast Cancer Patients

2011 ◽  
Vol 17 (3) ◽  
pp. 593-603 ◽  
Author(s):  
Lidija Beketic-Oreskovic ◽  
Petar Ozretic ◽  
Zahid N. Rabbani ◽  
Isabel L. Jackson ◽  
Bozena Sarcevic ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Carbonic Anhydrase ◽  
Cancer Patients ◽  
Prognostic Significance ◽  
Carbonic Anhydrase Ix ◽  
Breast Cancer Patients ◽  
Ca Ix

Carbonic anhydrase IX expression is associated with tumor progression and a poor prognosis of lung adenocarcinoma

Lung Cancer ◽  
2006 ◽  
Vol 54 (3) ◽  
pp. 409-418 ◽  
Author(s):  
Hidehiro Kon-no ◽  
Genichiro Ishii ◽  
Kanji Nagai ◽  
Junji Yoshida ◽  
Mitsuyo Nishimura ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Lung Adenocarcinoma ◽  
Tumor Progression ◽  
Poor Prognosis ◽  
Carbonic Anhydrase Ix

scholarly journals Prognostic Significance of Carbonic Anhydrase IX Expression in Cancer Patients: A Meta-Analysis

2016 ◽  
Vol 6 ◽  
Author(s):  
Simon J. A. van Kuijk ◽  
Ala Yaromina ◽  
Ruud Houben ◽  
Raymon Niemans ◽  
Philippe Lambin ◽  
...  
Keyword(s):  
Carbonic Anhydrase ◽  
Cancer Patients ◽  
Meta Analysis ◽  
Prognostic Significance ◽  
Carbonic Anhydrase Ix

780: Carbonic Anhydrase IX (CAIX) Expression and VHL Gene Alteration as Predictors of Survival in Renal Cell Carcinoma

2004 ◽  
Vol 171 (4S) ◽  
pp. 206-207 ◽  
Author(s):  
Hideki Mukouyama ◽  
Masahiro Yao ◽  
David B. Seligson ◽  
John S. Lam ◽  
Yoji Nagashima ◽  
...  
Keyword(s):  
Renal Cell Carcinoma ◽  
Carbonic Anhydrase ◽  
Cell Carcinoma ◽  
Renal Cell ◽  
Carbonic Anhydrase Ix ◽  
Vhl Gene ◽  
Gene Alteration ◽  
Caix Expression
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