NR3C1 gene polymorphism for genetic susceptibility to infantile spasms in a Chinese population

Life Sciences ◽  
2012 ◽  
Vol 91 (1-2) ◽  
pp. 37-43 ◽  
Author(s):  
Guang Yang ◽  
Li-Ping Zou ◽  
Bing He ◽  
Ying-Xue Ding ◽  
Jing Wang ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Genetic Susceptibility ◽  
Chinese Population ◽  
Infantile Spasms

CRP Gene polymorphism contributes genetic susceptibility to dyslipidemia in Han Chinese population

2014 ◽  
Vol 41 (4) ◽  
pp. 2335-2343 ◽  
Author(s):  
Wenbin Wei ◽  
Song Yang ◽  
Yingru Qiu ◽  
Hairu Wang ◽  
Xianghai Zhao ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Genetic Susceptibility ◽  
Chinese Population ◽  
Han Chinese ◽  
Han Chinese Population

Association of DNA repair gene XRCC1 and XPD polymorphisms with genetic susceptibility to gastric cancer in a Chinese population

2011 ◽  
Vol 35 (2) ◽  
pp. 170-174 ◽  
Author(s):  
Tao Yuan ◽  
Shaoli Deng ◽  
Ming Chen ◽  
Wei Chen ◽  
Weiping Lu ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Dna Repair ◽  
Genetic Susceptibility ◽  
Chinese Population ◽  
Repair Gene ◽  
Dna Repair Gene

scholarly journals Association of SERPINC1 Gene Polymorphism (rs2227589) With Pulmonary Embolism Risk in a Chinese Population

2019 ◽  
Vol 10 ◽  
Author(s):  
Yongjian Yue ◽  
Qing Sun ◽  
Lu Xiao ◽  
Shengguo Liu ◽  
Qijun Huang ◽  
...  
Keyword(s):  
Pulmonary Embolism ◽  
Gene Polymorphism ◽  
Chinese Population

Lack of Association of the Interleukin-1β Gene Polymorphism with Alzheimer’s Disease in a Chinese Population

2003 ◽  
Vol 16 (4) ◽  
pp. 265-268 ◽  
Author(s):  
Suk Ling Ma ◽  
Nelson Leung Sang Tang ◽  
Linda Chiu Wa Lam ◽  
Helen Fung Kum Chiu
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Gene Polymorphism ◽  
Chinese Population ◽  
Interleukin 1Β

scholarly journals Genetic susceptibility, dietary cholesterol intake, and plasma cholesterol levels in a Chinese population

2020 ◽  
Vol 61 (11) ◽  
pp. 1504-1511
Author(s):  
Shaofeng Huo ◽  
Liang Sun ◽  
Geng Zong ◽  
Boyu Song ◽  
He Zheng ◽  
...  
Keyword(s):  
Genetic Susceptibility ◽  
Chinese Population ◽  
Plasma Cholesterol ◽  
Nutrition Transition ◽  
Dietary Cholesterol ◽  
Effect Sizes ◽  
Risk Scores ◽  
Asian Countries ◽  
Cholesterol Levels ◽  
Cholesterol Intake

Accompanied with nutrition transition, non-HDL-C levels of individuals in Asian countries has increased rapidly, which has caused the global epicenter of nonoptimal cholesterol to shift from Western countries to Asian countries. Thus, it is critical to underline major genetic and dietary determinants. In the current study of 2,330 Chinese individuals, genetic risk scores (GRSs) were calculated for total cholesterol (TC; GRSTC, 57 SNPs), LDL-C (GRSLDL-C, 45 SNPs), and HDL-C (GRSHDL-C, 65 SNPs) based on SNPs from the Global Lipid Genetics Consortium study. Cholesterol intake was estimated by a 74-item food-frequency questionnaire. Associations of dietary cholesterol intake with plasma TC and LDL-C strengthened across quartiles of the GRSTC (effect sizes: −0.29, 0.34, 2.45, and 6.47; Pinteraction = 0.002) and GRSLDL-C (effect sizes: −1.35, 0.17, 5.45, and 6.07; Pinteraction = 0.001), respectively. Similar interactions with non-HDL-C were observed between dietary cholesterol and GRSTC (Pinteraction = 0.001) and GRSLDL-C (Pinteraction = 0.004). The adverse effects of GRSTC on TC (effect sizes across dietary cholesterol quartiles: 0.51, 0.82, 1.21, and 1.31; Pinteraction = 0.023) and GRSLDL-C on LDL-C (effect sizes across dietary cholesterol quartiles: 0.66, 0.52, 1.12, and 1.56; Pinteraction = 0.020) were more profound in those having higher cholesterol intake compared with those with lower intake. Our findings suggest significant interactions between genetic susceptibility and dietary cholesterol intake on plasma cholesterol profiles in a Chinese population.

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