Effect of repetitive ischemic preconditioning on spinal cord ischemia in a rabbit model

Life Sciences ◽  
2006 ◽  
Vol 79 (15) ◽  
pp. 1479-1483 ◽  
Author(s):  
Qi Jing YU ◽  
Yan Ling Wang ◽  
Qing Shan Zhou ◽  
Hai Bo Huang ◽  
Shu Fang Tian ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Ischemic Preconditioning ◽  
Spinal Cord Ischemia ◽  
Rabbit Model

Evaluation of Rapid Ischemic Preconditioning in a Rabbit Model of Spinal Cord Ischemia

2003 ◽  
Vol 99 (5) ◽  
pp. 1112-1117 ◽  
Author(s):  
Meiko Kakimoto ◽  
Masahiko Kawaguchi ◽  
Takanori Sakamoto ◽  
Satoki Inoue ◽  
Hitoshi Furuya ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Ischemic Preconditioning ◽  
Sham Group ◽  
Neuronal Damage ◽  
Spinal Cord Ischemia ◽  
Rabbit Model ◽  
Infrarenal Aorta ◽  
New Zealand White Rabbits ◽  
Histopathologic Evaluation ◽  
Group 5

Background Rapid ischemic preconditioning (IPC) has been shown to reduce cellular injury after subsequent cardiac and cerebral ischemia. However, the data on rapid IPC of the spinal cord is limited. The authors investigated whether pretreatment with sublethal ischemia of spinal cord can attenuate neuronal injury after spinal cord ischemia in rabbits. Methods Forty-seven male New Zealand white rabbits were randomly assigned to one of three groups (n = 15 or 16 each). In the IPC(-) group, the infrarenal aorta was occluded for 17 min to produce spinal cord ischemia. In the IPC(+) group, 5 min of aortic occlusion was performed 30 min before 17 min of spinal cord ischemia. In the sham group, the aorta was not occluded. Hind limb motor function was assessed at 3 h, 24 h, 4 days, and 7 days after reperfusion using Tarlov scoring (0 = paraplegia; 4 = normal). Animals were killed for histopathologic evaluation at 24 h or 7 days after reperfusion. The number of normal neurons in the anterior spinal cord (L4-L6) was counted. Results Neurologic scores were significantly higher in the IPC(+) group than the IPC(-) group at 3 and 24 h after reperfusion (P < 0.05). However, neurologic scores in the IPC(+) group gradually decreased and became similar to those in the IPC(-) group at 4 and 7 days after reperfusion. At 24 h after reperfusion, the numbers of normal neurons were significantly higher in the IPC (+) group than in the IPC(-) group (P < 0.05) and were similar between the IPC(+) and sham groups. At 7 days after reperfusion, there was no difference in the number of normal neurons between the IPC(+) and IPC(-) groups. Conclusion The results indicate that rapid IPC protects the spinal cord against neuronal damage 24 h but not 7 days after reperfusion in a rabbit model of spinal cord ischemia, suggesting that the efficacy of rapid IPC may be transient.

Rapid Ischemic Preconditioning with a Short Reperfusion Time Prevents Delayed Paraplegia in a Rabbit Model

2011 ◽  
Vol 14 (5) ◽  
pp. 317
Author(s):  
Mehmet Ozkokeli ◽  
Mehmet Ugur Es ◽  
Ugur Filizcan ◽  
Murat Ugurlucan ◽  
Ahmet Sasmazel ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Ischemic Preconditioning ◽  
Spinal Cord Ischemia ◽  
Rabbit Model ◽  
Aortic Aneurysms ◽  
Aortic Occlusion ◽  
Control Group ◽  
Protective Mechanisms ◽  
Group 13 ◽  
Histologic Evaluation

<p><b>Background:</b> Surgery for thoracic and thoracoabdominal aortic aneurysms can be complicated by a significant incidence of neurogenic deficits due to spinal cord ischemia. In this study, we investigated whether ischemic preconditioning (IPC) improves neurologic outcome in a rabbit model.</p><p><b>Methods:</b> Forty rabbits underwent infrarenal aortic occlusion. The IPC group (n = 20) had 10 minutes of aortic occlusion to induce spinal cord ischemia, 40 minutes of reperfusion, and 30 minutes of ischemia, whereas the control group (n = 20) had only 30 minutes of ischemia. Tarlov scoring (0, paraplegia; 4, normal) was used to evaluate neurologic functions 7 days later, and spinal cord segments (L4-L6) were stained with hematoxylin and eosin for histologic evaluation.</p><p><b>Results:</b> Complete paraplegia (grade 0) occurred in 15 (75%) of the 20 control animals, whereas in the IPC group, 13 (65%) of 20 animals were completely normal (grade 4) (<i>P</i> < .05).</p><p><b>Conclusion:</b> IPC is beneficial for protecting against neurologic damage after transient aortic occlusion in a rabbit model; however, the protective mechanisms are not clear.</p>

scholarly journals Spinal Cord Blood Flow after Ischemic Preconditioning in a Rat Model of Spinal Cord Ischemia

2004 ◽  
Vol 4 ◽  
pp. 892-898 ◽  
Author(s):  
David Zvara ◽  
James M. Zboyovski ◽  
Dwight D. Deal ◽  
Jason C. Vernon ◽  
David M. Colonna
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Cord Blood ◽  
Ischemic Preconditioning ◽  
Spinal Cord Ischemia ◽  
Flow Analysis ◽  
Lumbar Spinal Cord ◽  
Sprague Dawley ◽  
Spinal Cord Blood Flow ◽  
Significant Difference

Spinal cord blood flow after ischemic preconditioning is poorly characterized. This study is designed to evaluate spinal cord blood flow patterns in animals after acute ischemic preconditioning. Experiment 1: After a laminectomy and placement of a laser Doppler probe over the lumbar spinal cord to measure spinal cord blood flow, 16 male Sprague-Dawley rats were randomized into two groups: ischemic preconditioning (IPC, n = 8), and control (CTRL, n = 8). Rats in the CTRL and the IPC groups were subjected to 12 min of ischemia directly followed by 60 min of reperfusion. IPC rats received 3 min of IPC and 30 min of reperfusion prior to the 12-min insult period. Experiment 2: After instrumentation, the rats were randomized into three groups: control (CTRL, n = 7), ischemic preconditioning (IPC, n = 7), and time control (TC, n = 4). Rats in the CTRL and the IPC groups were subjected to the same ischemia and reperfusion protocol as above. The TC group was anesthetized for the same time period as the CTRL and the IPC groups, but had no ischemic intervention. Microspheres were injected at baseline and at 15 and 60 min into the final reperfusion. All rats were euthanized and tissue harvested for spinal cord blood flow analysis. In Experiment 1, there was a slight, significant difference in spinal cord blood flow during the ischemic period; however, this difference soon disappeared during reperfusion. In experiment 2, there was no difference in blood flow at any experimental time. The results of these experiments demonstrate that IPC slightly enhances blood flow to the spinal cord during ischemia; however, this effect is not sustained during the reperfusion period.

scholarly journals Blood flow and vascular permeability during motor dysfunction in a rabbit model of spinal cord ischemia.

Stroke ◽  
1992 ◽  
Vol 23 (3) ◽  
pp. 367-373 ◽  
Author(s):  
T P Jacobs ◽  
O Kempski ◽  
D McKinley ◽  
A J Dutka ◽  
J M Hallenbeck ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Vascular Permeability ◽  
Spinal Cord Ischemia ◽  
Rabbit Model ◽  
Motor Dysfunction

GLYBENCLAMIDE BLOCKS THE PROTECTIVE BENEFIT OF ISCHEMIC PRECONDITIONING IN A RAT MODEL OF SPINAL CORD ISCHEMIA

1999 ◽  
Vol 88 (Supplement) ◽  
pp. 80SCA
Author(s):  
DA Zvara ◽  
&NA; Colonna ◽  
DD Deal ◽  
JC Vernon ◽  
M Gowda
Keyword(s):  
Spinal Cord ◽  
Ischemic Preconditioning ◽  
Rat Model ◽  
Spinal Cord Ischemia

ISCHEMIC PRECONDITIONING REDUCES NEUROLOGIC INJURY IN A RAT MODEL OF SPINAL CORD ISCHEMIA

1998 ◽  
Vol 89 (Supplement) ◽  
pp. 684A
Author(s):  
David A Zvara ◽  
David M. Colonna ◽  
D. Deal ◽  
Jason C. Vernon ◽  
John C. Lundell
Keyword(s):  
Spinal Cord ◽  
Ischemic Preconditioning ◽  
Rat Model ◽  
Spinal Cord Ischemia ◽  
Neurologic Injury

196. A Novel Peroxynitrite Decomposition Catalyst Prevents Paralysis in a Rabbit Model of Spinal Cord Ischemia in Thoracic Aortic Stenting

2008 ◽  
Vol 144 (2) ◽  
pp. 264
Author(s):  
Mark L. Manwaring ◽  
Dorian J. deFreitas ◽  
Ken Salleng ◽  
Jacqueline C. Gustafson ◽  
Michael C. Stoner
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Ischemia ◽  
Rabbit Model ◽  
Aortic Stenting
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