scholarly journals Blood flow and vascular permeability during motor dysfunction in a rabbit model of spinal cord ischemia.

Stroke ◽  
1992 ◽  
Vol 23 (3) ◽  
pp. 367-373 ◽  
Author(s):  
T P Jacobs ◽  
O Kempski ◽  
D McKinley ◽  
A J Dutka ◽  
J M Hallenbeck ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Vascular Permeability ◽  
Spinal Cord Ischemia ◽  
Rabbit Model ◽  
Motor Dysfunction

scholarly journals Spinal Cord Blood Flow after Ischemic Preconditioning in a Rat Model of Spinal Cord Ischemia

2004 ◽  
Vol 4 ◽  
pp. 892-898 ◽  
Author(s):  
David Zvara ◽  
James M. Zboyovski ◽  
Dwight D. Deal ◽  
Jason C. Vernon ◽  
David M. Colonna
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Cord Blood ◽  
Ischemic Preconditioning ◽  
Spinal Cord Ischemia ◽  
Flow Analysis ◽  
Lumbar Spinal Cord ◽  
Sprague Dawley ◽  
Spinal Cord Blood Flow ◽  
Significant Difference

Spinal cord blood flow after ischemic preconditioning is poorly characterized. This study is designed to evaluate spinal cord blood flow patterns in animals after acute ischemic preconditioning. Experiment 1: After a laminectomy and placement of a laser Doppler probe over the lumbar spinal cord to measure spinal cord blood flow, 16 male Sprague-Dawley rats were randomized into two groups: ischemic preconditioning (IPC, n = 8), and control (CTRL, n = 8). Rats in the CTRL and the IPC groups were subjected to 12 min of ischemia directly followed by 60 min of reperfusion. IPC rats received 3 min of IPC and 30 min of reperfusion prior to the 12-min insult period. Experiment 2: After instrumentation, the rats were randomized into three groups: control (CTRL, n = 7), ischemic preconditioning (IPC, n = 7), and time control (TC, n = 4). Rats in the CTRL and the IPC groups were subjected to the same ischemia and reperfusion protocol as above. The TC group was anesthetized for the same time period as the CTRL and the IPC groups, but had no ischemic intervention. Microspheres were injected at baseline and at 15 and 60 min into the final reperfusion. All rats were euthanized and tissue harvested for spinal cord blood flow analysis. In Experiment 1, there was a slight, significant difference in spinal cord blood flow during the ischemic period; however, this difference soon disappeared during reperfusion. In experiment 2, there was no difference in blood flow at any experimental time. The results of these experiments demonstrate that IPC slightly enhances blood flow to the spinal cord during ischemia; however, this effect is not sustained during the reperfusion period.

196. A Novel Peroxynitrite Decomposition Catalyst Prevents Paralysis in a Rabbit Model of Spinal Cord Ischemia in Thoracic Aortic Stenting

2008 ◽  
Vol 144 (2) ◽  
pp. 264
Author(s):  
Mark L. Manwaring ◽  
Dorian J. deFreitas ◽  
Ken Salleng ◽  
Jacqueline C. Gustafson ◽  
Michael C. Stoner
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Ischemia ◽  
Rabbit Model ◽  
Aortic Stenting

Effects of the 21-aminosteroid U74006F on posttraumatic spinal cord ischemia in cats

1988 ◽  
Vol 68 (3) ◽  
pp. 462-465 ◽  
Author(s):  
Edward D. Hall
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Sodium Succinate ◽  
Spinal Cord Ischemia ◽  
Intravenous Dose ◽  
Content Type ◽  
Methylprednisolone Sodium Succinate ◽  
Surprising Effect ◽  
Surgical Preparation ◽  
Dorsolateral Funiculus

✓ The ability of a single intravenous dose of the 21-aminosteroid U74006F to affect the development of posttraumatic spinal cord ischemia was examined in pentobarbital-anesthetized cats. After surgical preparation, each animal received a 300 gm-cm contusion injury to the exposed L-3 vertebral segment, followed by a single bolus injection of vehicle or U74006F (3 or 10 mg/kg) at 30 minutes postinjury. Spinal cord white matter blood flow (SCBF) was measured by hydrogen clearance in the dorsolateral funiculus in the center of the injured segment before and at various times up to 4 hours after injury. In vehicle-treated cats, there was a progressive decline in SCBF over the course of the experiment. By 4 hours postinjury, SCBF had decreased from a preinjury value of 15.9 ± 2.4 ml/100 gm/min (mean ± standard error of the mean) to 5.8 ± 0.8 ml/100 gm/min, representing a decline of 63.5%. In contrast, the SCBF measured 4 hours postinjury in cats that were treated with a single 10-mg/kg dose of U74006F was 13.6 ± 1.7 ml/100 gm/min (p < 0.001 vs. vehicle). Animals that received a 3-mg/kg intravenous dose of U74006F displayed a drop in SCBF equal to that of vehicle-treated cats. However, when a 3-mg/kg dose of U74006F was given to four vehicle-treated cats at the end of the experiment, a partial reversal of ischemia was recorded. Blood flow increased within 30 minutes from a mean of 4.5 ± 0.8 to 7.4 ± 1.0 ml/100 gm/min or an increase of 64.4% (p < 0.05). This rather surprising effect of U74006F in reversing posttraumatic ischemia once it has developed significantly is not shared by a 30-mg/kg intravenous dose of methylprednisolone sodium succinate (MP), although MP has previously been shown to attenuate the posttraumatic drop in SCBF when given before the SCBF drop occurs. The mechanism of action of U74006F in antagonizing posttraumatic ischemia development is believed to involve the ability of the compound to inhibit iron-dependent lipid peroxidation in central nervous system tissue.

Evaluation of Rapid Ischemic Preconditioning in a Rabbit Model of Spinal Cord Ischemia

2003 ◽  
Vol 99 (5) ◽  
pp. 1112-1117 ◽  
Author(s):  
Meiko Kakimoto ◽  
Masahiko Kawaguchi ◽  
Takanori Sakamoto ◽  
Satoki Inoue ◽  
Hitoshi Furuya ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Ischemic Preconditioning ◽  
Sham Group ◽  
Neuronal Damage ◽  
Spinal Cord Ischemia ◽  
Rabbit Model ◽  
Infrarenal Aorta ◽  
New Zealand White Rabbits ◽  
Histopathologic Evaluation ◽  
Group 5

Background Rapid ischemic preconditioning (IPC) has been shown to reduce cellular injury after subsequent cardiac and cerebral ischemia. However, the data on rapid IPC of the spinal cord is limited. The authors investigated whether pretreatment with sublethal ischemia of spinal cord can attenuate neuronal injury after spinal cord ischemia in rabbits. Methods Forty-seven male New Zealand white rabbits were randomly assigned to one of three groups (n = 15 or 16 each). In the IPC(-) group, the infrarenal aorta was occluded for 17 min to produce spinal cord ischemia. In the IPC(+) group, 5 min of aortic occlusion was performed 30 min before 17 min of spinal cord ischemia. In the sham group, the aorta was not occluded. Hind limb motor function was assessed at 3 h, 24 h, 4 days, and 7 days after reperfusion using Tarlov scoring (0 = paraplegia; 4 = normal). Animals were killed for histopathologic evaluation at 24 h or 7 days after reperfusion. The number of normal neurons in the anterior spinal cord (L4-L6) was counted. Results Neurologic scores were significantly higher in the IPC(+) group than the IPC(-) group at 3 and 24 h after reperfusion (P &lt; 0.05). However, neurologic scores in the IPC(+) group gradually decreased and became similar to those in the IPC(-) group at 4 and 7 days after reperfusion. At 24 h after reperfusion, the numbers of normal neurons were significantly higher in the IPC (+) group than in the IPC(-) group (P &lt; 0.05) and were similar between the IPC(+) and sham groups. At 7 days after reperfusion, there was no difference in the number of normal neurons between the IPC(+) and IPC(-) groups. Conclusion The results indicate that rapid IPC protects the spinal cord against neuronal damage 24 h but not 7 days after reperfusion in a rabbit model of spinal cord ischemia, suggesting that the efficacy of rapid IPC may be transient.

scholarly journals Towards rapid intraoperative axial localization of spinal cord ischemia with epidural diffuse correlation monitoring

PLoS ONE ◽  
2021 ◽  
Vol 16 (5) ◽  
pp. e0251271
Author(s):  
David R. Busch ◽  
Wei Lin ◽  
Chia Chieh Goh ◽  
Feng Gao ◽  
Nicholas Larson ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Cord Blood ◽  
Spinal Cord Ischemia ◽  
Correlation Spectroscopy ◽  
Spinal Cord Blood Flow ◽  
Doppler Flowmetry ◽  
Spatially Resolved ◽  
Highly Correlated ◽  
Sensitivity Specificity

Spinal cord ischemia leads to iatrogenic injury in multiple surgical fields, and the ability to immediately identify onset and anatomic origin of ischemia is critical to its management. Current clinical monitoring, however, does not directly measure spinal cord blood flow, resulting in poor sensitivity/specificity, delayed alerts, and delayed intervention. We have developed an epidural device employing diffuse correlation spectroscopy (DCS) to monitor spinal cord ischemia continuously at multiple positions. We investigate the ability of this device to localize spinal cord ischemia in a porcine model and validate DCS versus Laser Doppler Flowmetry (LDF). Specifically, we demonstrate continuous (>0.1Hz) spatially resolved (3 locations) monitoring of spinal cord blood flow in a purely ischemic model with an epidural DCS probe. Changes in blood flow measured by DCS and LDF were highly correlated (r = 0.83). Spinal cord blood flow measured by DCS caudal to aortic occlusion decreased 62%. This monitor demonstrated a sensitivity of 0.87 and specificity of 0.91 for detection of a 25% decrease in flow. This technology may enable early identification and critically important localization of spinal cord ischemia.

scholarly journals Preventive Effect of Edaravone Injection before Aortic Clamping for Spinal Cord Ischemia in a Rabbit Model

2016 ◽  
Vol 56 (8) ◽  
pp. 109-115
Author(s):  
Masahiro Sagane ◽  
Kiyoshi Chiba ◽  
Satoshi Kinebuchi ◽  
Shota Kita ◽  
Daijun Ro ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Ischemia ◽  
Rabbit Model ◽  
Preventive Effect ◽  
Aortic Clamping

Effects of Spinal Cord Ischemia on Evoked Potential Recovery and Postischemic Regional Spinal Cord Blood Flow

1993 ◽  
Vol 6 (2) ◽  
pp. 146???154 ◽  
Author(s):  
Richard K. Osenbach ◽  
Patrick W. Hitchon ◽  
Loren Mouw ◽  
Thoru Yamada
Keyword(s):  
Spinal Cord ◽  
Blood Flow ◽  
Cord Blood ◽  
Evoked Potential ◽  
Spinal Cord Ischemia ◽  
Spinal Cord Blood Flow
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