scholarly journals Precision medicine comes of age in nephrology: identification of novel biomarkers and therapeutic targets for chronic kidney disease

2016 ◽  
Vol 89 (4) ◽  
pp. 734-737 ◽  
Author(s):  
Christina M. Wyatt ◽  
Detlef Schlondorff
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Precision Medicine ◽  
Therapeutic Targets ◽  
Novel Biomarkers

Chronic kidney disease: Biomarker diagnosis to therapeutic targets

2019 ◽  
Vol 499 ◽  
pp. 54-63 ◽  
Author(s):  
Yan-Ni Wang ◽  
Shi-Xing Ma ◽  
Yuan-Yuan Chen ◽  
Lin Chen ◽  
Bao-Li Liu ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Therapeutic Targets ◽  
Disease Biomarker

scholarly journals Unique aspects of peripheral artery disease in patients with chronic kidney disease

2019 ◽  
Vol 24 (3) ◽  
pp. 251-260 ◽  
Author(s):  
Nkiruka V Arinze ◽  
Andrew Gregory ◽  
Jean M Francis ◽  
Alik Farber ◽  
Vipul C Chitalia
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Peripheral Artery Disease ◽  
Clinical Aspects ◽  
Peripheral Artery ◽  
Health Care Burden ◽  
High Prevalence ◽  
Novel Biomarkers ◽  
Artery Disease ◽  
Poor Outcomes

Peripheral artery disease (PAD) represents a major health care burden. Despite the advent of screening and interventional procedures, the long-term clinical outcomes remain suboptimal, especially in patients with chronic kidney disease (CKD). While CKD and PAD share common predisposing factors, emerging studies indicate that their co-existence is not merely an association; instead, CKD represents a strong, independent risk factor for PAD. These findings implicate CKD-specific mediators of PAD that remain incompletely understood. Moreover, there is a need to understand the mechanisms underlying poor outcomes after interventions for PAD in CKD. This review discusses unique clinical aspects of PAD in patients with CKD, including high prevalence and worse outcomes after vascular interventions and the influence of renal allograft transplantation. In doing so, it also highlights underappreciated aspects of PAD in patients with CKD, such as disparities in revascularization and higher peri-procedural mortality. While previous reviews have discussed general mechanisms of PAD pathogenesis, focusing on PAD in CKD, this review underscores a need to probe for CKD-specific pathogenic pathways that may unravel novel biomarkers and therapeutic targets in PAD and ultimately improve the risk stratification and management of patients with CKD and PAD.

scholarly journals Cases in Precision Medicine: APOL1 and Genetic Testing in the Evaluation of Chronic Kidney Disease and Potential Transplant

2019 ◽  
Vol 171 (9) ◽  
pp. 659 ◽  
Author(s):  
Y. Dana Neugut ◽  
Sumit Mohan ◽  
Ali G. Gharavi ◽  
Krzysztof Kiryluk
Keyword(s):  
Chronic Kidney Disease ◽  
Genetic Testing ◽  
Kidney Disease ◽  
Precision Medicine

scholarly journals Make Precision Medicine Work for Chronic Kidney Disease

2016 ◽  
Vol 26 (2) ◽  
pp. 101-107 ◽  
Author(s):  
Ling Sun ◽  
Lu-Xi Zou ◽  
Mao-Jie Chen
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Precision Medicine
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