scholarly journals The wrapping method using biodegradable felt strips has a preventive effect on the thinning of the aortic wall: Experimental study in the canine aorta

2006 ◽  
Vol 43 (2) ◽  
pp. 349-356 ◽  
Author(s):  
Hidenori Fujiwara ◽  
Katsuhiko Oda ◽  
Yoshikatsu Saiki ◽  
Naoya Sakamoto ◽  
Toshiro Ohashi ◽  
...  
Keyword(s):  
Experimental Study ◽  
Aortic Wall ◽  
Preventive Effect ◽  
Canine Aorta

EFFECT OF POLLEN TYPHAE ON 6-KETO-PGF , TXB2, TOTAL CHOLESTEROL AND HDL-C IN RABBITS WITH CHRONIC HYPERLIPIDEMIA

1987 ◽  
Author(s):  
Z Y Wang ◽  
L Zhang ◽  
Y L Su
Keyword(s):  
High Density Lipoprotein ◽  
Total Cholesterol ◽  
High Density Lipoprotein Cholesterol ◽  
Aortic Wall ◽  
Density Lipoprotein ◽  
Inverse Correlation ◽  
Experimental Atherosclerosis ◽  
Chinese Traditional Medicine ◽  
Preventive Effect ◽  
Better Than

62 NZW rabbits were divided into 4 groups: (1) Control (C), (2) rabbits fed with high lipids diet (H), (3) H+pollen Typhae (H+P), (4) H+VitE (H+E). The following parameters were determined: (1) total cholesterol of aortic wall (WTC), (2) Serum TC (STC), High density lipoprotein cholesterol (HDL-C), (3) Plasma 6-keto-PGF1 (6-keto) and thromboxane B2 (TXB2), (4) 6-keto of aortic wall, (5) ratio of STC/HDL-C and plasma TXB2/6-ketoThe results showed that: (1) the level of WTC, STC and STC/HDL-C was significantly higher in the group H than in the group C, while that of 6-keto was lower (P < 0.01), (2) STC, WTC and plasma TXB2, TXB2 /6-keto all were significantly lower in the group H+P than m the group H, while wall's 6-keto was higher (P < 0.01).There was inverse correlation between plasma 6-keto and STC/HDL-C (P < 0.01), while positive correlation has been found between STC/HDL-C and plasma TXB2/6-keto (P < 0.05).In the group H+E, the plasma TXB2/6-keto, was lower than in the group H, the wall's 6-keto was higher, but there was no difference between the groups H+E and H+P. The STC and WTC were higher in the group H+E than in the group H+P, although lower than in the group H.It has been demonstrated in our Department that the Chinese traditional medicine Pollen Typhae had preventive effect on the experimental atherosclerosis in rabbit fed with high lipids diet, the mechanism would not only due to its effect lowering the STC, WTC and STC/HDL-C, but also to its action on the metabolism of prostaglandins. Its action on lowering STC and WTC appeared to be better than VitE, however, the latter had similar effect on the metabolism of prostaglandins as compared with Pollen Typhae.

scholarly journals Preventive effect of pomegranate juice against chemically induced bladder cancer: An experimental study

Heliyon ◽  
2020 ◽  
Vol 6 (10) ◽  
pp. e05192
Author(s):  
Wael I. Mortada ◽  
Amira Awadalla ◽  
Sherry M. Khater ◽  
Nashwa M. Barakat ◽  
Sherif M. Husseiny ◽  
...  
Keyword(s):  
Experimental Study ◽  
Bladder Cancer ◽  
Pomegranate Juice ◽  
Preventive Effect ◽  
Chemically Induced

The complete preventive effect of homologous tumor vaccines – Based on a 5-year experimental study in mice

2010 ◽  
Vol 64 (9) ◽  
pp. 605-608
Author(s):  
Xinglong Tong ◽  
Ling Wang ◽  
Yanping Liu ◽  
Yuqiao Qi ◽  
Yugou Qin ◽  
...  
Keyword(s):  
Experimental Study ◽  
Preventive Effect ◽  
Tumor Vaccines

Enhancement of ADP-Induced Platelet Aggregation by Cholesterol and Its Prevention by Pyridinolcarbamate

1973 ◽  
Vol 29 (03) ◽  
pp. 684-693 ◽  
Author(s):  
Tadahiro Sano ◽  
Hiroh Yamazaki ◽  
Takio Shimamoto
Keyword(s):  
Platelet Count ◽  
Platelet Aggregation ◽  
Aortic Wall ◽  
Preventive Effect ◽  
Induce Platelet Aggregation ◽  
Minimum Concentration ◽  
Platelet Aggregability ◽  
Cholesterol Intake ◽  
Blood Coagulability

SummaryThe authors reported a transient decrease in adhesive platelet count and an enhancement of blood coagulability after administration of cholesterol in rabbits. In such circumstances, platelet aggregability to ADP was examined by 2 methods: 1. measurement of intensity of platelet aggregation induced by ADP using the optical density method and 2. determination of minimum concentration of ADP solution to induce platelet aggregation using a light microscope. Three hours after oral administration of 1 g/kg of cholesterol, the intensity of aggregation in 12 rabbits increased to 106.0 ±2.4% (mean ± S. E.) by 10 ìM, 108.5 ±2.6% by 3 ìM and 110.2 ±3.7% of the value before the administration by 1 ìM of ADP. The differences were statistically significant (P <0.05). At that time, platelet in CPRP collected after cholesterol intake were aggregated by eight-times diluted ADP solution compared to that collected before cholesterol administration in 2 rabbits, four-times in 4 and two-times in 3 among 10 cases. Pyridinolcarbamate, which showed preventive effect against appearance of edematous changes in aortic wall induced by cholesterol and/or adrenaline, prevented these phenomena, when it was given 10 mg/kg orally 3 hours prior to cholesterol administration.

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