scholarly journals Nitric oxide–releasing biopolymers inhibit thrombus formation in a sheep model of arteriovenous bridge grafts

2004 ◽  
Vol 40 (4) ◽  
pp. 803-811 ◽  
Author(s):  
Paul S. Fleser ◽  
Vijay K. Nuthakki ◽  
Lauren E. Malinzak ◽  
Rose E. Callahan ◽  
Marilyn L. Seymour ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Thrombus Formation ◽  
Sheep Model ◽  
Nitric Oxide Releasing

scholarly journals Novel Photoinitiated Nitric Oxide Releasing Compounds for More Biocompatible Coatings on Blood and Tissue Contacting Medical Devices

2009 ◽  
Vol 3 (2) ◽  
Author(s):  
B. M. Burgess ◽  
G. E. Gierke ◽  
M. C. Frost
Keyword(s):  
Nitric Oxide ◽  
Thrombus Formation ◽  
Neointimal Hyperplasia ◽  
Vascular Grafts ◽  
Blood Gases ◽  
Surface Fluxes ◽  
Biomedical Devices ◽  
Polymer Fillers ◽  
Nitric Oxide Releasing

Biomedical devices that contact blood and tissue universally inspire a host response that often compromises the function of the device (i.e., intravascular sensors become coated with thrombi, artificial vascular grafts become coated with thrombi, artificial vascular grafts become occluded with thrombus formation and neointimal hyperplasia). Nitric oxide (NO) has been shown to be a potent inhibitor of platelet adhesion and activation and has been implicated in mediating the inflammatory response and promoting would healing. We are currently developing NO-releasing compounds based on S-nitrosothiols derived from substituted aromatic compounds that utilize light as an external on/off trigger capable of releasing precisely controlled surface fluxes of NO. The level of NO generated is dependent on the wavelength and intensity of light shown on the compounds. Data will be presented that show the synthesis and NO-release properties of three novel compounds, S-nitroso-2-methoxybenzene, S-nitroso-3-methoxybenzene and S-nitroso-2-chlorobenzene. Ultimately, these compounds will be tethered to the surface of polymer fillers that will then be blended into hydrophobic polymers and used as coatings on biomedical devices. A model system that will be used to demonstrate the utility of this approach will be a multi-element fiber optic sensors that will contain sensing elements capable of measuring blood gases and NO-releasing fibers that locally generate enough NO to inhibit clot formation on the sensor surface, thus allowing the sensor to function reliably in vivo.

scholarly journals Novel Photoinitiated Nitric Oxide Releasing Compounds for More Biocompatible Coatings on Blood and Tissue Contacting Medical Devices

2009 ◽  
Vol 3 (2) ◽  
Author(s):  
B. M. Burgess ◽  
M. C. Frost
Keyword(s):  
Nitric Oxide ◽  
Thrombus Formation ◽  
Neointimal Hyperplasia ◽  
Blood Gases ◽  
Surface Fluxes ◽  
Biomedical Devices ◽  
Hydrophobic Polymers ◽  
Polymer Fillers ◽  
Nitric Oxide Releasing

Biomedical devices that contact blood and tissue universally inspire a host response that often compromises the function of the device (i.e., intravascular sensors become coated with thrombi, artificial vascular grafts become occluded with thrombus formation and neointimal hyperplasia). Nitric oxide (NO) has been shown to be a potent inhibitor of platelet adhesion and activation and has been implicated in mediating the inflammatory response and promoting wound healing. We are currently developing NO-releasing compounds based on S-nitrosothiols derived from substituted aromatic compounds that utilize light as an external on/off trigger capable of releasing precisely controlled surface fluxes of NO. The level of NO generated is dependent on the wavelength and intensity of light shown on the compounds. Data will be presented that show the synthesis and NO-release properties of three novel compounds, S-nitroso-2-methoxybenzene, S-nitroso-3-methoxybenzene and S-nitroso-2-chlorobenzene. Ultimately, these compounds will be tethered to the surface of polymer fillers that will then be blended into hydrophobic polymers and used as coatings on biomedical devices. A model system that will be used to demonstrate the utility of this approach will be a multi-element fiber optic sensors that will contain sensing elements capable of measuring blood gases and NO-releasing fibers that locally generate enough NO to inhibit clot formation on the sensor surface, thus allowing the sensor to function reliably in vivo.

scholarly journals Reduction in thrombosis and bacterial adhesion with 7 day implantation of S-nitroso-N-acetylpenicillamine (SNAP)-doped Elast-eon E2As catheters in sheep

2015 ◽  
Vol 3 (8) ◽  
pp. 1639-1645 ◽  
Author(s):  
Elizabeth J. Brisbois ◽  
Ryan P. Davis ◽  
Anna M. Jones ◽  
Terry C. Major ◽  
Robert H. Bartlett ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Bacterial Adhesion ◽  
Sheep Model ◽  
Doped Polymers ◽  
Nitric Oxide Releasing

Nitric oxide-releasing catheters, prepared with S-nitroso-N-acetylpenicillamine doped polymers, reduce thrombus and bacterial adhesion in a 7 day sheep model.

Study on Preparation and Properties of Nitric Oxide Releasing Polyurethane

2009 ◽  
Vol 610-613 ◽  
pp. 1237-1243
Author(s):  
Jian Hao Zhao ◽  
Mei Tu ◽  
Rong Zeng ◽  
Jie Geng ◽  
Zhen Gang Cha ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Platelet Adhesion ◽  
Blood Compatibility ◽  
Thrombus Formation ◽  
Film Surface ◽  
Fluorescence Analysis ◽  
Ratio Measurement ◽  
Behavior Study ◽  
Surface Fluorescence ◽  
Nitric Oxide Releasing

In this study, a novel nitric oxide (NO) endogenously releasing polyurethane (PU) material, i.e. PU-g-L-cysteine(PU-Cys), was synthesized by grafting L-cysteine on the film surface. Fluorescence analysis and a BCA method were used to characterize qualitatively and quantitatively the grafted L-cysteine. The results showed that L-cysteine was successfully immobilized on the PU film surface and the density of L-cysteine grafted was calculated to be 15.3nmol/cm2. The NO releasing behavior study of PU-Cys film demonstrated that endogenous NO could be continuously released from PU-Cys film and the accumulated releasing amount within 3h added up to 1.06nmol/cm2. The releasing rate of NO was well matchable to the self-releasing rate of resting platelets in human body. The results of dynamic blood clotting test and hemolysis ratio measurement showed that PU-Cys film had a better haemocompatibility than PU film, which might be the result of endogenously released NO inhibiting platelet adhesion and thrombus formation. Therefore, PU-Cys with the property of endogenous NO releasing is expected to be an ideal blood compatibility material in clinical application.

Nitric Oxide-Releasing Biomaterials for Biomedical Applications

2016 ◽  
Vol 23 (24) ◽  
pp. 2579-2601 ◽  
Author(s):  
Xin Zhou ◽  
Jimin Zhang ◽  
Guowei Feng ◽  
Jie Shen ◽  
Deling Kong ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Biomedical Applications ◽  
Nitric Oxide Releasing

scholarly journals Doxycycline-Loaded Nitric Oxide-Releasing Nanomatrix Gel in Replanted Rat Molar on Pulp Regeneration

2021 ◽  
Vol 11 (13) ◽  
pp. 6041
Author(s):  
Kwan-Hee Yun ◽  
Mi-Ja Ko ◽  
Yong-Kown Chae ◽  
Koeun Lee ◽  
Ok-Hyung Nam ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Standard Deviation ◽  
Treatment Group ◽  
Root Surface ◽  
Lower Grade ◽  
Histomorphometric Analysis ◽  
Pulp Regeneration ◽  
Pulp Inflammation ◽  
Nitric Oxide Releasing ◽  
Rat Molar

The aim of the present study was to evaluate the effect of doxycycline-loaded NO-releasing nanomatrix gel on pulp regeneration in replantation of avulsed rat teeth. A total of 28 maxillary first molars extracted from rats were replanted. The rats were divided into two groups based on the use of root surface treatment: doxycycline-loaded NO-releasing nanomatrix group and no treatment. Eight weeks after replantation, the rats were sacrificed, and the teeth were evaluated using histomorphometric analysis. On histomorphometric analysis, the NO-releasing nanomatrix group demonstrated a significantly lower grade of pulp inflammation (1.00 ± 1.11, mean ± standard deviation) compared to the no treatment group (2.21 ± 1.25, p = 0.014). NO-releasing nanomatrix group showed a significantly higher grade of pulp regeneration (2.57 ± 0.85, p = 0.012) and significantly lower grade of pulp inflammation (1.00 ± 0.68, p = 0.025) compared to the no treatment group. In conclusion, NO-releasing nanomatrix gel improved pulp regeneration of replanted teeth, though the sample size of this study was rather small. Within the limits of this study, NO-releasing nanomatrix gel can provide more favorable pulpal regeneration despite replantation.

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