scholarly journals Commentary: This is your brain, and this is your brain on deep hypothermic cardiac arrest

2019 ◽  
Vol 158 (3) ◽  
pp. 893-894 ◽  
Author(s):  
James Jaggers
Keyword(s):  
Cardiac Arrest ◽  
Deep Hypothermic Cardiac Arrest

Abstract 103: Rewarming Speed Affects Cardiopulmonary and Neurological Functions After Deep Hypothermic Cardiac Arrest

Circulation ◽  
2019 ◽  
Vol 140 (Suppl_2) ◽  
Author(s):  
Daniele Linardi ◽  
Beat H Walpoth ◽  
Romel Mani ◽  
Maddalena M Tessari ◽  
Ilaria Decimo ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Extracorporeal Circulation ◽  
Neuronal Damage ◽  
Core Body Temperature ◽  
Brain Mri ◽  
Lung Edema ◽  
Sprague Dawley ◽  
Adult Rats ◽  
Hemodynamic Assessment ◽  
Deep Hypothermic Cardiac Arrest

Introduction: The optimal rewarming rate from accidental or induced deep hypothermia is still unknown. Fast extracorporeal rewarming by extracorporeal circulation has been associated with cardiac dysfunction, pulmonary edema and poor neurologic outcome. Hypothesis: This study investigates whether the speed of rewarming after deep hypothermic cardiac arrest has neurological and cardiopulmonary effects. Methods: Thirty male Sprague-Dawley adult rats (450-550g) were rapidly cooled (ice packs) until 15°C core body temperature. Deep hypothermic cardiac arrest was maintained for 60 min. Thereafter rats were randomised to receive slow (90 minutes) or fast (30 minutes) rewarming by cardiopulmonary bypass to a target temperature of 35°C. After 90 minutes of reperfusion all animals underwent hemodynamic assessment by biventricular pressure-volume analysis, brain MRI and heart, lungs and brain were collected. Results: Slow rewarming preserved cardiac systolic and diastolic functions, ventricular arterial coupling and endothelium dependent relaxation. Lung edema was attenuated after slow rewarming. Cardimyocytes pro-survival kinases ERK and Akt activation were significantly higher in the slow rewarming group. MRI demonstrated enhancement of cerebral blood flow and reduction of cerebral edema after slow rewarming. Neurologic inflammatory response measured by IL-6, ICAM-1, CCL5 and TNF-α expression was significantly decreased in the slow rewarming group. Oxidative stress assessed by malondialdehyde was significantly reduced after slow rewarming. Conclusion: Slow rewarming by extracorporeal circulation after deep hypothermic cardiac arrest might improve systolic and diastolic function, preserve ventricular-arterial coupling, attenuate cerebral perfusion impairment and reduce neuronal damage.

The Role of Deep Hypothermic Cardiac Arrest in the Surgical Treatment of Complex Intracranial Aneurysms

2011 ◽  
Vol 6 (3) ◽  
pp. 204
Author(s):  
Bruno M Santiago ◽  
Cátia Gradil ◽  
Manuel Cunha e Sá ◽  
◽  
◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Surgical Treatment ◽  
Intracranial Aneurysms ◽  
Cerebral Protection ◽  
Circulatory Control ◽  
Deep Hypothermic Cardiac Arrest

Giant and complex intracranial aneurysms can be formidable lesions to tackle from a surgical standpoint. Their treatment has witnessed an enormous improvement in recent decades with the development of several technical refinements, both surgical and endovascular. By combining optimal cerebral protection with extended periods of circulatory control, deep hypothermic cardiac arrest (DHCA) is a useful adjunct for appropriately dealing with very select cases. In this article we discuss the rationale behind the use of DHCA and review the results of the most relevant series recently published. DHCA remains an important though exceptional way of surgically treating giant and complex intracranial aneurysms.

Extracorporeal-Assisted Rewarming in the Management of Accidental Deep Hypothermic Cardiac Arrest

2014 ◽  
Vol 23 (11) ◽  
pp. 1029-1035 ◽  
Author(s):  
Ben Dunne ◽  
Erasmia Christou ◽  
Oonagh Duff ◽  
Christopher Merry
Keyword(s):  
Cardiac Arrest ◽  
Deep Hypothermic Cardiac Arrest

scholarly journals Deep Hypothermic Cardiac Arrest Treated by Extracorporeal Life Support in a Porcine Model: Does the Rewarming Method Matter?

2016 ◽  
Vol 23 (6) ◽  
pp. 665-673 ◽  
Author(s):  
Guillaume Debaty ◽  
Maxime Maignan ◽  
Bertrand Perrin ◽  
Angélique Brouta ◽  
Dorra Guergour ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Porcine Model ◽  
Life Support ◽  
Extracorporeal Life Support ◽  
Deep Hypothermic Cardiac Arrest

scholarly journals Evaluation of Seizure Risk in Infants After Cardiopulmonary Bypass in the Absence of Deep Hypothermic Cardiac Arrest

2021 ◽  
Author(s):  
Rebecca J. Levy ◽  
Elizabeth W. Mayne ◽  
Amanda G. Sandoval Karamian ◽  
Mehreen Iqbal ◽  
Natasha Purington ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Cardiopulmonary Bypass ◽  
Deep Hypothermic Cardiac Arrest

Myocardial protective effect of deep hypothermic cardiac arrest without aortic cross clamp in neonatal hearts: Comparison with cardioplegic arrest in a rabbit model

1994 ◽  
Vol 9 (4) ◽  
pp. 188-193 ◽  
Author(s):  
Tomokatsu Inoue ◽  
Yoshiki Sawa ◽  
Hikaru Matsuda ◽  
Yasuhisa Shimazaki ◽  
Mitsunori Kaneko ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Protective Effect ◽  
Rabbit Model ◽  
Cardioplegic Arrest ◽  
Aortic Cross Clamp ◽  
Deep Hypothermic Cardiac Arrest

Low plasma potassium in deep hypothermic cardiac arrest indicates that cardiac arrest is secondary to hypothermia: a porcine study

2010 ◽  
Vol 17 (3) ◽  
pp. 131-135 ◽  
Author(s):  
Benedict Kjaergaard ◽  
Louise K. Jakobsen ◽  
Conny Nielsen ◽  
Peter J. Knudsen ◽  
Søren R. Kristensen ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Plasma Potassium ◽  
Deep Hypothermic Cardiac Arrest
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