Myocardial protective effect of deep hypothermic cardiac arrest without aortic cross clamp in neonatal hearts: Comparison with cardioplegic arrest in a rabbit model

1994 ◽  
Vol 9 (4) ◽  
pp. 188-193 ◽  
Author(s):  
Tomokatsu Inoue ◽  
Yoshiki Sawa ◽  
Hikaru Matsuda ◽  
Yasuhisa Shimazaki ◽  
Mitsunori Kaneko ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Protective Effect ◽  
Rabbit Model ◽  
Cardioplegic Arrest ◽  
Aortic Cross Clamp ◽  
Deep Hypothermic Cardiac Arrest

scholarly journals Managament of Conversions to Cardiopulmonary Bypass in Beating Heart Coronary Surgery

2008 ◽  
Vol 8 (3) ◽  
pp. 266-269
Author(s):  
Emir Mujanović ◽  
Jacob Bergsland ◽  
Sanja Stanimirović-Mujanović ◽  
Emir Kabil
Keyword(s):  
Cardiac Arrest ◽  
Cardiopulmonary Bypass ◽  
Artery Bypass ◽  
Technical Difficulty ◽  
Hemodynamic Instability ◽  
Beating Heart ◽  
Bypass Grafting ◽  
Cardioplegic Arrest ◽  
Intraaortic Balloon Pump ◽  
Clinical Centre

This study investigated outcomes in patients undergoing coronary artery bypass grafting (CABG) without cardiopulmonary bypass (CPB), who needed conversion to CPB. Between September, 1998 and September, 2003, 1000 CABG procedures were performed in a Cardiovascular Clinic, University Clinical Centre Tuzla. Multivessel CABG were selected arbitrarily for CABG without CPB (OPCAB) or CABG with CPB (ONCAB). Patients who required conversion due to technical difficulty with grafting were performed with ONCAB including cardioplegic arrest. Patients with severe hemodynamic instability and cardiac arrest were performed as ONCAB without crossclamping, while patients converted for mild to moderate hemodynamic instability were given cardioplegic arrest or not, depending on surgeon preference. 493 operations were scheduled and performed as ONCAB (49,3%), 468 as OPCAB (46,8%) and 39 originally scheduled OPCAB operations were converted to ONCAB (7,7% of originally scheduled OPCAB patients or 3,9% of total number of CABG). Reasons for conversions were: mild to severe hemodynamic instability - 28 (71,8%); poor vessels or difficult graft revision - 11 (28,2%). Patients converted because of technical difficulty or mild hemodynamic instability behaved as regular ONCAB patients. In the 9 patients who were emergently converted due to cardiac arrest or ventricular fibrillation, 3 patients had stroke and 3 severe myocardial ischemia requiring intraaortic balloon pump. It is of great importance to keep conversions to CPB due to cardiac arrest at a low level. The serious complications seen in such patients can significantly impede the overall benefits of a successful OPCAB program.

Abstract 103: Rewarming Speed Affects Cardiopulmonary and Neurological Functions After Deep Hypothermic Cardiac Arrest

Circulation ◽  
2019 ◽  
Vol 140 (Suppl_2) ◽  
Author(s):  
Daniele Linardi ◽  
Beat H Walpoth ◽  
Romel Mani ◽  
Maddalena M Tessari ◽  
Ilaria Decimo ◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Extracorporeal Circulation ◽  
Neuronal Damage ◽  
Core Body Temperature ◽  
Brain Mri ◽  
Lung Edema ◽  
Sprague Dawley ◽  
Adult Rats ◽  
Hemodynamic Assessment ◽  
Deep Hypothermic Cardiac Arrest

Introduction: The optimal rewarming rate from accidental or induced deep hypothermia is still unknown. Fast extracorporeal rewarming by extracorporeal circulation has been associated with cardiac dysfunction, pulmonary edema and poor neurologic outcome. Hypothesis: This study investigates whether the speed of rewarming after deep hypothermic cardiac arrest has neurological and cardiopulmonary effects. Methods: Thirty male Sprague-Dawley adult rats (450-550g) were rapidly cooled (ice packs) until 15°C core body temperature. Deep hypothermic cardiac arrest was maintained for 60 min. Thereafter rats were randomised to receive slow (90 minutes) or fast (30 minutes) rewarming by cardiopulmonary bypass to a target temperature of 35°C. After 90 minutes of reperfusion all animals underwent hemodynamic assessment by biventricular pressure-volume analysis, brain MRI and heart, lungs and brain were collected. Results: Slow rewarming preserved cardiac systolic and diastolic functions, ventricular arterial coupling and endothelium dependent relaxation. Lung edema was attenuated after slow rewarming. Cardimyocytes pro-survival kinases ERK and Akt activation were significantly higher in the slow rewarming group. MRI demonstrated enhancement of cerebral blood flow and reduction of cerebral edema after slow rewarming. Neurologic inflammatory response measured by IL-6, ICAM-1, CCL5 and TNF-α expression was significantly decreased in the slow rewarming group. Oxidative stress assessed by malondialdehyde was significantly reduced after slow rewarming. Conclusion: Slow rewarming by extracorporeal circulation after deep hypothermic cardiac arrest might improve systolic and diastolic function, preserve ventricular-arterial coupling, attenuate cerebral perfusion impairment and reduce neuronal damage.

The Role of Deep Hypothermic Cardiac Arrest in the Surgical Treatment of Complex Intracranial Aneurysms

2011 ◽  
Vol 6 (3) ◽  
pp. 204
Author(s):  
Bruno M Santiago ◽  
Cátia Gradil ◽  
Manuel Cunha e Sá ◽  
◽  
◽  
...  
Keyword(s):  
Cardiac Arrest ◽  
Surgical Treatment ◽  
Intracranial Aneurysms ◽  
Cerebral Protection ◽  
Circulatory Control ◽  
Deep Hypothermic Cardiac Arrest

Giant and complex intracranial aneurysms can be formidable lesions to tackle from a surgical standpoint. Their treatment has witnessed an enormous improvement in recent decades with the development of several technical refinements, both surgical and endovascular. By combining optimal cerebral protection with extended periods of circulatory control, deep hypothermic cardiac arrest (DHCA) is a useful adjunct for appropriately dealing with very select cases. In this article we discuss the rationale behind the use of DHCA and review the results of the most relevant series recently published. DHCA remains an important though exceptional way of surgically treating giant and complex intracranial aneurysms.

Protective Effect of an Asanguineous Reperfusion Solution on Myocardial Performance Following Cardioplegic Arrest

1984 ◽  
Vol 37 (3) ◽  
pp. 222-228 ◽  
Author(s):  
Philippe Menasché ◽  
Christian Grousset ◽  
Georges de Boccard ◽  
Armand Piwnica
Keyword(s):  
Protective Effect ◽  
Myocardial Performance ◽  
Cardioplegic Arrest

KLF4 Upregulation in Atherosclerotic Thoracic Aortas: Exploring the Protective Effect of Colchicine-based Regimens in a Hyperlipidemic Rabbit Model

2021 ◽  
Author(s):  
Konstantinos S. Mylonas ◽  
Alkistis Kapelouzou ◽  
Michael Spartalis ◽  
Michael Mastrogeorgiou ◽  
Eletherios Spartalis ◽  
...  
Keyword(s):  
Protective Effect ◽  
Rabbit Model ◽  
Hyperlipidemic Rabbit
Sign in / Sign up

Export Citation Format

Share Document