scholarly journals Effects of Custodiol-N, a novel organ preservation solution, on ischemia/reperfusion injury

2010 ◽  
Vol 139 (4) ◽  
pp. 1048-1056 ◽  
Author(s):  
Sivakkanan Loganathan ◽  
Tamás Radovits ◽  
Kristóf Hirschberg ◽  
Sevil Korkmaz ◽  
Achim Koch ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Organ Preservation ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Preservation Solution ◽  
Organ Preservation Solution

Prolonged Mouse Cardiac Graft Cold Storage via Attenuating Ischemia-Reperfusion Injury Using a New Antioxidant-Based Preservation Solution

2016 ◽  
Vol 100 (5) ◽  
pp. 1032-1040 ◽  
Author(s):  
Songjie Cai ◽  
Naotsugu Ichimaru ◽  
Mingyi Zhao ◽  
Masayuki Fujino ◽  
Hidenori Ito ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Cold Storage ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Preservation Solution ◽  
Cardiac Graft

scholarly journals Therapeutic Potential of Selenium as a Component of Preservation Solutions for Kidney Transplantation

Molecules ◽  
2020 ◽  
Vol 25 (16) ◽  
pp. 3592
Author(s):  
Aneta Ostróżka-Cieślik ◽  
Barbara Dolińska ◽  
Florian Ryszka
Keyword(s):  
Reperfusion Injury ◽  
Activity Concentration ◽  
Ischemia Reperfusion Injury ◽  
Therapeutic Potential ◽  
Ischemia Reperfusion ◽  
Antioxidant Properties ◽  
Preservation Solution ◽  
Kidney Preservation ◽  
Preservation Solutions ◽  
Metabolic Reduction

Selenium has strong antioxidant properties and diverse effects on the immune system. The aim of the study was to analyse the protective effect of selenium as a component of a kidney preservation solution on the prevention of ischemia-reperfusion injury of nephrons. The solution was modified by the addition of Se (1 µg/L), prolactin (0.1 µg/L) and Se with prolactin (1 µg/L Se + 0.1 µg/L PRL). The study used a model for storing isolated porcine kidneys in Biolasol® (modified Biolasol®), which minimizes ischemia-reperfusion injury of grafts. The introduction of Se4+ ions at a dose of 1 µg/L into the Biolasol® preservation solution in the form of Na2SeO3 caused an increase in the activity/concentration of the analysed biochemical parameters: aspartate transaminase, alanine transaminase, urea and protein. This suggests an adverse effect of Se4+ on nephron function during ischemia-reperfusion. The best graft protection was obtained by using Biolasol® modified with the addition of selenium (IV) at a dose of 1 µg/L and prolactin at a concentration of 0.1 µg/L. We proposed the mechanism of prolactin action in the metabolic reduction of selenite (SO32−) during ischemia/reperfusion.

Erythropoietin as Additive of HTK Preservation Solution in Cold Ischemia/Reperfusion Injury of Steatotic Livers

2012 ◽  
Vol 173 (1) ◽  
pp. 171-179 ◽  
Author(s):  
Christian Eipel ◽  
Ulrike Hübschmann ◽  
Kerstin Abshagen ◽  
Klaus F. Wagner ◽  
Michael D. Menger ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cold Ischemia ◽  
Preservation Solution

Modulation of Ischemia/Reperfusion Injury of Liver Grafts with An Oxygen Carrier (Perfluorocarbon)-Based Preservation Solution

2012 ◽  
Vol 94 (10S) ◽  
pp. 453
Author(s):  
P. N. Martins ◽  
H. Yeh ◽  
B. Bruinsma ◽  
M.-L. Izamis ◽  
S. A. Abdelwahed ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Oxygen Carrier ◽  
Preservation Solution

Immune Responses in Kidney Preservation and Reperfusion Injury

2004 ◽  
Vol 52 (5) ◽  
pp. 310-314 ◽  
Author(s):  
Niamh E. Kieran ◽  
Hamid Rabb
Keyword(s):  
Reperfusion Injury ◽  
Organ Preservation ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Organ Transplant ◽  
Experimental Models ◽  
Kidney Preservation ◽  
Immune Mediators ◽  
Preservation Injury ◽  
Short And Long Term

Organ preservation and reperfusion injury have significant detrimental effects on both short- and long-term organ function. Ischemia reperfusion injury (IRI) underlies organ transplant dysfunction, myocardial infarction, stroke, and shock. Multiple molecular pathways are engaged in reactive oxygen production, apoptosis, signaling, and tissue regeneration. There has been an increased understanding of the important role of immune and inflammatory pathways in IRI, both in humans and in experimental models. Both cellular and soluble components of the immune system are directly activated during IRI, and there is evidence that immune mediators directly contribute to organ dysfunction. Immune activation during IRI likely underlies the enhanced immunogenicity of ischemic organs, with resultant increased rejection and fibrosis. Novel human therapies targeting T and B cells for classic immune diseases can now be considered to prevent and treat IRI. Organ preservation injury and cold ischemia could well have distinct pathophysiology from warm IRI and represent an opportunity to develop improved preservation methods.

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