Cold ischemia/reperfusion injury in a mouse model of partial liver transplantation

2013 ◽  
Vol 181 (2) ◽  
pp. 337-341 ◽  
Author(s):  
Guodong Wang ◽  
Bin Hu ◽  
Zhi Li
Keyword(s):  
Liver Transplantation ◽  
Mouse Model ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cold Ischemia ◽  
Partial Liver Transplantation

Carbon monoxide inhalation ameliorates cold ischemia/reperfusion injury after rat liver transplantation

Surgery ◽  
2005 ◽  
Vol 138 (2) ◽  
pp. 229-235 ◽  
Author(s):  
Takashi Kaizu ◽  
Atsunori Nakao ◽  
Allan Tsung ◽  
Hideyoshi Toyokawa ◽  
Rohit Sahai ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Rat Liver ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cold Ischemia ◽  
Rat Liver Transplantation

scholarly journals Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Keiichi Uto ◽  
Seisuke Sakamoto ◽  
Weitao Que ◽  
Keita Shimata ◽  
Shintaro Hashimoto ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Rat Liver ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cold Ischemia ◽  
Rat Liver Transplantation ◽  
Rich Solution

Involvement of Rho-Kinase in Cold Ischemia-Reperfusion Injury after Liver Transplantation in Rats

2004 ◽  
Vol 78 (3) ◽  
pp. 375-382 ◽  
Author(s):  
Satoko Shiotani ◽  
Mitsuo Shimada ◽  
Taketoshi Suehiro ◽  
Yuji Soejima ◽  
Tomoharu Yosizumi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Rho Kinase ◽  
Cold Ischemia

Roles of dendritic cells in murine hepatic warm and liver transplantation-induced cold ischemia/reperfusion injury

Hepatology ◽  
2013 ◽  
Vol 57 (4) ◽  
pp. 1585-1596 ◽  
Author(s):  
Matthew Zhang ◽  
Shinya Ueki ◽  
Shoko Kimura ◽  
Osamu Yoshida ◽  
Antonino Castellaneta ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Dendritic Cells ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cold Ischemia

scholarly journals Endogenous Interleukin-33 Acts as an Alarmin in Liver Ischemia-Reperfusion and Is Associated With Injury After Human Liver Transplantation

2021 ◽  
Vol 12 ◽  
Author(s):  
Louise Barbier ◽  
Aurélie Robin ◽  
Rémy Sindayigaya ◽  
Héloïse Ducousso ◽  
Fanny Dujardin ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Renal Failure ◽  
Mouse Model ◽  
Reperfusion Injury ◽  
Human Liver ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Graft Dysfunction ◽  
Hepatic Ischemia ◽  
Transplant Patients

Ischemia and reperfusion injury is an early inflammatory process during liver transplantation that impacts on graft function and clinical outcomes. Interleukin (IL)-33 is a danger-associated molecular pattern involved in kidney ischemia/reperfusion injury and several liver diseases. The aims were to assess whether IL-33 was released as an alarmin responsible for ischemia/reperfusion injury in a mouse model of warm hepatic ischemia, and whether this hypothesis could also apply in the setting of human liver transplantation. First, a model of warm hepatic ischemia/reperfusion was used in wild-type and IL-33–deficient mice. Severity of ischemia/reperfusion injury was assessed with ALT and histological analysis. Then, serum IL-33 was measured in a pilot cohort of 40 liver transplant patients. Hemodynamic postreperfusion syndrome, graft dysfunction (assessed by model for early allograft scoring >6), renal failure, and tissue lesions on time-zero biopsies were assessed. In the mouse model, IL-33 was constitutively expressed in the nucleus of endothelial cells, immediately released in response to hepatic pedicle clamping without neosynthesis, and participated in the recruitment of neutrophils and tissue injury on site. The kinetics of IL-33 in liver transplant patients strikingly matched the ones in the animal model, as attested by serum levels reaching a peak immediately after reperfusion, which correlated to clinical outcomes including postreperfusion syndrome, posttransplant renal failure, graft dysfunction, and histological lesions of ischemia/reperfusion injury. IL-33 was an independent factor of graft dysfunction with a cutoff of IL-33 at 73 pg/ml after reperfusion (73% sensitivity, area under the curve of 0.76). Taken together, these findings establish the immediate implication of IL-33 acting as an alarmin in liver I/R injury and provide evidence of its close association with cardinal features of early liver injury-associated disorders in LT patients.

scholarly journals Hepatic B7 homolog 1 expression is essential for controlling cold ischemia/reperfusion injury after mouse liver transplantation

Hepatology ◽  
2011 ◽  
Vol 54 (1) ◽  
pp. 216-228 ◽  
Author(s):  
Shinya Ueki ◽  
Antonino Castellaneta ◽  
Osamu Yoshida ◽  
Kikumi Ozaki ◽  
Matthew Zhang ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Mouse Liver ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cold Ischemia
Sign in / Sign up

Export Citation Format

Share Document