Roles of dendritic cells in murine hepatic warm and liver transplantation-induced cold ischemia/reperfusion injury

Hepatology ◽  
2013 ◽  
Vol 57 (4) ◽  
pp. 1585-1596 ◽  
Author(s):  
Matthew Zhang ◽  
Shinya Ueki ◽  
Shoko Kimura ◽  
Osamu Yoshida ◽  
Antonino Castellaneta ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Dendritic Cells ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cold Ischemia

Carbon monoxide inhalation ameliorates cold ischemia/reperfusion injury after rat liver transplantation

Surgery ◽  
2005 ◽  
Vol 138 (2) ◽  
pp. 229-235 ◽  
Author(s):  
Takashi Kaizu ◽  
Atsunori Nakao ◽  
Allan Tsung ◽  
Hideyoshi Toyokawa ◽  
Rohit Sahai ◽  
...  
Keyword(s):  
Carbon Monoxide ◽  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Rat Liver ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cold Ischemia ◽  
Rat Liver Transplantation

scholarly journals Hydrogen-rich solution attenuates cold ischemia-reperfusion injury in rat liver transplantation

2019 ◽  
Vol 19 (1) ◽  
Author(s):  
Keiichi Uto ◽  
Seisuke Sakamoto ◽  
Weitao Que ◽  
Keita Shimata ◽  
Shintaro Hashimoto ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Rat Liver ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cold Ischemia ◽  
Rat Liver Transplantation ◽  
Rich Solution

Involvement of Rho-Kinase in Cold Ischemia-Reperfusion Injury after Liver Transplantation in Rats

2004 ◽  
Vol 78 (3) ◽  
pp. 375-382 ◽  
Author(s):  
Satoko Shiotani ◽  
Mitsuo Shimada ◽  
Taketoshi Suehiro ◽  
Yuji Soejima ◽  
Tomoharu Yosizumi ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Rho Kinase ◽  
Cold Ischemia

scholarly journals Hepatic B7 homolog 1 expression is essential for controlling cold ischemia/reperfusion injury after mouse liver transplantation

Hepatology ◽  
2011 ◽  
Vol 54 (1) ◽  
pp. 216-228 ◽  
Author(s):  
Shinya Ueki ◽  
Antonino Castellaneta ◽  
Osamu Yoshida ◽  
Kikumi Ozaki ◽  
Matthew Zhang ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Mouse Liver ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cold Ischemia

scholarly journals Impact of Three Methods of Ischemic Preconditioning on Ischemia-Reperfusion Injury in a Pig Model of Liver Transplantation

2021 ◽  
pp. 1-10
Author(s):  
Alessandro Rodrigo Belon ◽  
Ana Cristina Aoun Tannuri ◽  
Daniel de Albuquerque Rangel Moreira ◽  
Jose Luiz Figueiredo ◽  
Alessandra Matheus da Silva ◽  
...  
Keyword(s):  
Liver Transplantation ◽  
Reperfusion Injury ◽  
Ischemic Preconditioning ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Pig Model

scholarly journals Transplantation-Induced Ischemia-Reperfusion Injury Modulates Antigen Presentation by Donor Renal CD11c+F4/80+ Macrophages through IL-1R8 Regulation

2020 ◽  
Vol 31 (3) ◽  
pp. 517-531 ◽  
Author(s):  
Sistiana Aiello ◽  
Manuel Alfredo Podestà ◽  
Pamela Y. Rodriguez-Ordonez ◽  
Francesca Pezzuto ◽  
Nadia Azzollini ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Antigen Presentation ◽  
Kidney Transplant ◽  
Ischemia Reperfusion Injury ◽  
Ischemia Reperfusion ◽  
Cold Ischemia ◽  
Reversible Ischemia ◽  
Antigen Presenting

BackgroundIn donor kidneys subjected to ischemia-reperfusion injury during kidney transplant, phagocytes coexpressing the F4/80 and CD11c molecules mediate proinflammatory responses and trigger adaptive immunity in transplantation through antigen presentation. After injury, however, resident renal macrophages coexpressing these surface markers acquire a proreparative phenotype, which is pivotal in controlling inflammation and fibrosis. No data are currently available regarding the effects of transplant-induced ischemia-reperfusion injury on the ability of donor-derived resident renal macrophages to act as professional antigen-presenting cells.MethodsWe evaluated the phenotype and function of intragraft CD11c+F4/80+ renal macrophages after cold ischemia. We also assessed the modifications of donor renal macrophages after reversible ischemia-reperfusion injury in a mouse model of congeneic renal transplantation. To investigate the role played by IL-1R8, we conducted in vitro and in vivo studies comparing cells and grafts from wild-type and IL-R8–deficient donors.ResultsCold ischemia and reversible ischemia-reperfusion injury dampened antigen presentation by renal macrophages, skewed their polarization toward the M2 phenotype, and increased surface expression of IL-1R8, diminishing activation mediated by toll-like receptor 4. Ischemic IL-1R8–deficient donor renal macrophages acquired an M1 phenotype, effectively induced IFNγ and IL-17 responses, and failed to orchestrate tissue repair, resulting in severe graft fibrosis and aberrant humoral immune responses.ConclusionsIL-1R8 is a key regulator of donor renal macrophage functions after ischemia-reperfusion injury, crucial to guiding the phenotype and antigen-presenting role of these cells. It may therefore represent an intriguing pathway to explore with respect to modulating responses against autoantigens and alloantigens after kidney transplant.

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