Factors associated with phyllodes tumor of the breast after core needle biopsy identifies fibroepithelial neoplasm

2012 ◽  
Vol 178 (1) ◽  
pp. 299-303 ◽  
Author(s):  
Daniel J. Gould ◽  
Jessica A. Salmans ◽  
Brian K. Lassinger ◽  
Alejandro Contreras ◽  
Carolina Gutierrez ◽  
...  
Keyword(s):  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Phyllodes Tumor ◽  
Core Needle ◽  
Factors Associated

Development of a Management Algorithm for the Diagnosis of Cellular Fibroepithelial Lesions From Core Needle Biopsies

2018 ◽  
Vol 26 (8) ◽  
pp. 684-692 ◽  
Author(s):  
Jaehag Jung ◽  
Eunyoung Kang ◽  
Su Min Chae ◽  
Hyojin Kim ◽  
So Yeon Park ◽  
...  
Keyword(s):  
Core Needle Biopsy ◽  
Scoring System ◽  
Needle Biopsy ◽  
Characteristic Curve ◽  
Phyllodes Tumor ◽  
Surgical Excision ◽  
Multivariate Logistic Regression Model ◽  
Core Needle ◽  
Factors Associated ◽  
Phyllodes Tumors

Purpose. Surgical excision is recommended for complete evaluation of cellular fibroepithelial lesions identified from core needle biopsy. The purpose of this study was to determine factors associated with phyllodes tumor among cellular fibroepithelial lesions from core biopsies and develop a scoring system to predict the risk of phyllodes tumor. Methods. We retrospectively reviewed clinical data of 169 breast lesions that were diagnosed as cellular fibroepithelial lesions from core needle biopsy at the Seoul National University Bundang Hospital between March 2005 and January 2013. The clinical, histopathologic, and radiologic characteristics were compared between phyllodes tumors and fibroadenomas during the final diagnosis after surgical excision. Results. Of the 169 lesions, 17 were observed and 152 were surgically removed. After excision, final pathology revealed 60 (39.5%) fibroadenomas and 92 (60.5%) phyllodes tumors. Multivariate analysis demonstrated that age (≥40 years), stromal overgrowth, and stromal cellularity were independent factors associated with phyllodes tumors. A scoring system was developed based on a multivariate logistic regression model, and the area under the receiver operating characteristic curve was 0.828 (95% confidence interval = 0.763-0.893). Conclusion. The scoring system will help clinicians make appropriate treatment for patients with cellular fibroepithelial lesions on core needle biopsy.

scholarly journals Factors associated with disease upgrading in patients with papillary breast lesion in core-needle biopsy

Gland Surgery ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 919-924
Author(s):  
Shin-Young Park ◽  
SeungSang Ko ◽  
Chan Seok Yoon ◽  
Hae Kyung Lee ◽  
Sung Soo Kang ◽  
...  
Keyword(s):  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Breast Lesion ◽  
Core Needle ◽  
Factors Associated

Atypical Ductal Hyperplasia Diagnosed at Sonographically Guided Core Needle Biopsy: Frequency, Final Surgical Outcome, and Factors Associated With Underestimation

2014 ◽  
Vol 202 (6) ◽  
pp. 1389-1394 ◽  
Author(s):  
Benoît Mesurolle ◽  
Juan Carlos Hidalgo Perez ◽  
Fahad Azzumea ◽  
Emmanuelle Lemercier ◽  
Xuanqian Xie ◽  
...  
Keyword(s):  
Core Needle Biopsy ◽  
Surgical Outcome ◽  
Needle Biopsy ◽  
Atypical Ductal Hyperplasia ◽  
Core Needle ◽  
Factors Associated ◽  
Ductal Hyperplasia

Phyllodes Tumors

2017 ◽  
Author(s):  
Tina J Hieken ◽  
Rafael E Jimenez
Keyword(s):  
High Risk ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Phyllodes Tumor ◽  
Oncologic Outcomes ◽  
Breast Adenocarcinoma ◽  
Adjuvant Radiation ◽  
Core Needle ◽  
Phyllodes Tumors ◽  
Stromal Component

Phyllodes tumors are rare primary breast neoplasms graded as benign, borderline, or malignant based on pathology characterization of the stromal component. Core-needle biopsy is recommended as the first diagnostic step for breast lesions suspicious for phyllodes. Surgical excisional biopsy is recommended for a core-needle biopsy showing cellular fibroepithelial lesion or a mass suspicious for phyllodes tumor as pathology diagnosis is challenging, especially on limited tissue specimens. Surgical treatment parallels that for soft tissue sarcoma rather than breast adenocarcinoma. Wide local excision and mastectomy, with 1 cm tumor-free margins, provide equivalent oncologic outcomes. Tumor enucleation, subtotal resection, and positive final margins should be avoided. Axillary surgery is not recommended as lymph node metastases are rare. Adjuvant radiation is not recommended as routine, nor is adjuvant chemotherapy, although either or both may be considered for primary or recurrent high-risk malignant phyllodes tumors on a case-by-case basis. Local recurrence rates are influenced by margin status and tumor grade. Distant metastases occur in up to 25% of patients with borderline/malignant tumors and bestow a poor prognosis. Recent molecular genetic analyses of phyllodes tumors have identified potentially targetable mutations that may guide future therapy for high-risk, recurrent, or metastatic phyllodes tumors. This review contains 5 figures, 5 tables, and 53 references. Key words: biomarkers, breast sarcoma, diagnosis, outcomes, pathology, phyllodes tumor, surgery, treatment

scholarly journals Can We Predict Phyllodes Tumor among Fibroepithelial Lesions with Cellular Stroma Diagnosed at Breast Core Needle Biopsy?

2011 ◽  
Vol 64 (6) ◽  
pp. 603 ◽  
Author(s):  
Hae Kyoung Jung ◽  
Kyung Hee Ko ◽  
Ji Young Rho ◽  
Hee Jung Moon ◽  
Eun-Kyung Kim ◽  
...  
Keyword(s):  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Phyllodes Tumor ◽  
Core Needle

Phyllodes Tumors

2017 ◽  
Author(s):  
Tina J Hieken ◽  
Rafael E Jimenez
Keyword(s):  
High Risk ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Phyllodes Tumor ◽  
Oncologic Outcomes ◽  
Breast Adenocarcinoma ◽  
Adjuvant Radiation ◽  
Core Needle ◽  
Phyllodes Tumors ◽  
Stromal Component

Phyllodes tumors are rare primary breast neoplasms graded as benign, borderline, or malignant based on pathology characterization of the stromal component. Core-needle biopsy is recommended as the first diagnostic step for breast lesions suspicious for phyllodes. Surgical excisional biopsy is recommended for a core-needle biopsy showing cellular fibroepithelial lesion or a mass suspicious for phyllodes tumor as pathology diagnosis is challenging, especially on limited tissue specimens. Surgical treatment parallels that for soft tissue sarcoma rather than breast adenocarcinoma. Wide local excision and mastectomy, with 1 cm tumor-free margins, provide equivalent oncologic outcomes. Tumor enucleation, subtotal resection, and positive final margins should be avoided. Axillary surgery is not recommended as lymph node metastases are rare. Adjuvant radiation is not recommended as routine, nor is adjuvant chemotherapy, although either or both may be considered for primary or recurrent high-risk malignant phyllodes tumors on a case-by-case basis. Local recurrence rates are influenced by margin status and tumor grade. Distant metastases occur in up to 25% of patients with borderline/malignant tumors and bestow a poor prognosis. Recent molecular genetic analyses of phyllodes tumors have identified potentially targetable mutations that may guide future therapy for high-risk, recurrent, or metastatic phyllodes tumors. This review contains 5 figures, 5 tables, and 53 references. Key words: biomarkers, breast sarcoma, diagnosis, outcomes, pathology, phyllodes tumor, surgery, treatment

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