Near-Infrared Multichannel Raman Spectroscopy with a 1064 nm Excitation Wavelength for Ex Vivo Diagnosis of Gastric Cancer

2011 ◽  
Vol 169 (2) ◽  
pp. e137-e143 ◽  
Author(s):  
Toshiki Kawabata ◽  
Hirotoshi Kikuchi ◽  
Shigetoshi Okazaki ◽  
Masayoshi Yamamoto ◽  
Yoshihiro Hiramatsu ◽  
...  
Author(s):  
Hirotoshi Kikuchi ◽  
Toshiki Kawabata ◽  
Shigetoshi Okazaki ◽  
Yoshihiro Hiramatsu ◽  
Megumi Baba ◽  
...  

2008 ◽  
Vol 43 (4) ◽  
pp. 283-290 ◽  
Author(s):  
Toshiki Kawabata ◽  
Toshihiko Mizuno ◽  
Shigetoshi Okazaki ◽  
Mitsuo Hiramatsu ◽  
Tomohiko Setoguchi ◽  
...  

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 922
Author(s):  
William Querido ◽  
Shital Kandel ◽  
Nancy Pleshko

Advances in vibrational spectroscopy have propelled new insights into the molecular composition and structure of biological tissues. In this review, we discuss common modalities and techniques of vibrational spectroscopy, and present key examples to illustrate how they have been applied to enrich the assessment of connective tissues. In particular, we focus on applications of Fourier transform infrared (FTIR), near infrared (NIR) and Raman spectroscopy to assess cartilage and bone properties. We present strengths and limitations of each approach and discuss how the combination of spectrometers with microscopes (hyperspectral imaging) and fiber optic probes have greatly advanced their biomedical applications. We show how these modalities may be used to evaluate virtually any type of sample (ex vivo, in situ or in vivo) and how “spectral fingerprints” can be interpreted to quantify outcomes related to tissue composition and quality. We highlight the unparalleled advantage of vibrational spectroscopy as a label-free and often nondestructive approach to assess properties of the extracellular matrix (ECM) associated with normal, developing, aging, pathological and treated tissues. We believe this review will assist readers not only in better understanding applications of FTIR, NIR and Raman spectroscopy, but also in implementing these approaches for their own research projects.


2011 ◽  
Vol 26 (10) ◽  
pp. 4104-4110 ◽  
Author(s):  
Mads Sylvest Bergholt ◽  
Wei Zheng ◽  
Kan Lin ◽  
Khek Yu Ho ◽  
Ming Teh ◽  
...  

2000 ◽  
Author(s):  
Martin G. Shim ◽  
Louis-Michel Wong Kee Song ◽  
Norman E. Marcon ◽  
Shirley Hassaram ◽  
Brian C. Wilson

2011 ◽  
Author(s):  
Jun Ma ◽  
Wei-zheng Mao ◽  
Ming Xu ◽  
Long-jing Gong ◽  
Yuan Gao ◽  
...  

2008 ◽  
Vol 13 (3) ◽  
pp. 034013 ◽  
Author(s):  
Seng Khoon Teh ◽  
Wei Zheng ◽  
Khek Yu Ho ◽  
Ming Teh ◽  
Khay Guan Yeoh ◽  
...  

Author(s):  
Yukihiro Ozaki

Recently-developed near-infrared Fourier transform (FT)-Raman spectroscopy has received keen interest of researchers in bio-Raman field because near-infrared excitation can avoid mostly fluorescence and photodecomposition, which have been two major drawbacks of Raman spectroscopy in its biological and medical applications. Introduction of FT-Raman microspectroscopy makes near-infrared FT-Raman spectroscopy more useful for studying biomedical materials. The purpose of the present paper is to demonstrate the potential of near-infrared FT-Raman microspectroscopy in nondestructive structural analysis of biological systems. Photosynthetic bacteria is taken up here as an example.The FT-Raman spectra of the photosynthetic bacteria were measured with a JEOL JRS-FT6500N FT-Raman spectrometer equipped with an optical microscopy. Excitation wavelength at 1064-nm was provided by a CW Nd:YAG laser (CVI YAGMAX c-92), and the laser power at the sample position was typically 150 mW. All the data were collected at a spectral resolution of 8 cm-1 and spatial resolution of 8 μm.


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