Localization of genetic elements of intact and derivative chromosome 11 and 22 territories in nuclei of Ewing sarcoma cells

2006 ◽  
Vol 155 (3) ◽  
pp. 493-504 ◽  
Author(s):  
Renata Taslerová ◽  
Stanislav Kozubek ◽  
Eva Bártová ◽  
Pavla Gajdušková ◽  
Roman Kodet ◽  
...  
Keyword(s):  
Ewing Sarcoma ◽  
Derivative Chromosome ◽  
Chromosome 11 ◽  
Genetic Elements ◽  
Sarcoma Cells

Arrangement of chromosome 11 and 22 territories, EWSR1 and FLI1 genes, and other genetic elements of these chromosomes in human lymphocytes and Ewing sarcoma cells

2003 ◽  
Vol 112 (2) ◽  
pp. 143-155 ◽  
Author(s):  
Renata Taslerová ◽  
Stanislav Kozubek ◽  
Emilie Lukášová ◽  
Pavla Jirsová ◽  
Eva Bártová ◽  
...  
Keyword(s):  
Ewing Sarcoma ◽  
Human Lymphocytes ◽  
Chromosome 11 ◽  
Genetic Elements ◽  
Sarcoma Cells

Translocation of oncogene c-sis from chromosome 22 to chromosome 11 in a Ewing sarcoma-derived cell line

1985 ◽  
Vol 5 (2) ◽  
pp. 427-429
Author(s):  
A G van Kessel ◽  
C Turc-Carel ◽  
A de Klein ◽  
G Grosveld ◽  
G Lenoir ◽  
...  
Keyword(s):  
Ewing Sarcoma ◽  
Myeloid Leukemia ◽  
Philadelphia Chromosome ◽  
Chinese Hamster ◽  
Chromosome 22 ◽  
Chromosome 11 ◽  
Breakpoint Cluster Region ◽  
Cluster Region ◽  
Sarcoma Cells ◽  
Chromosome Breakpoint

Somatic cell hybrids, obtained after fusion of translocation (11;22)-positive Ewing sarcoma cells and Chinese hamster fibroblasts, were assayed for the presence of immunoglobulin C lambda, Philadelphia chromosome breakpoint cluster region, and c-sis oncogene sequences. It was found that c-sis was translocated from chromosome 22 to chromosome 11 in the Ewing sarcoma cells used, indicating that the breakpoint must be proximal to this locus. Moreover, we found that the chromosome 22-linked C lambda and breakpoint cluster region sequences are not translocated. This result confirms an earlier cytogenetic observation that the Ewing sarcoma-associated breakpoint in chromosome 22 is distal to those observed in translocation (8;22)-positive Burkitt lymphoma and in Philadelphia chromosome-positive chronic myeloid leukemia.

scholarly journals Translocation of oncogene c-sis from chromosome 22 to chromosome 11 in a Ewing sarcoma-derived cell line.

1985 ◽  
Vol 5 (2) ◽  
pp. 427-429 ◽  
Author(s):  
A G van Kessel ◽  
C Turc-Carel ◽  
A de Klein ◽  
G Grosveld ◽  
G Lenoir ◽  
...  
Keyword(s):  
Ewing Sarcoma ◽  
Myeloid Leukemia ◽  
Philadelphia Chromosome ◽  
Chinese Hamster ◽  
Chromosome 22 ◽  
Chromosome 11 ◽  
Breakpoint Cluster Region ◽  
Cluster Region ◽  
Sarcoma Cells ◽  
Chromosome Breakpoint

Somatic cell hybrids, obtained after fusion of translocation (11;22)-positive Ewing sarcoma cells and Chinese hamster fibroblasts, were assayed for the presence of immunoglobulin C lambda, Philadelphia chromosome breakpoint cluster region, and c-sis oncogene sequences. It was found that c-sis was translocated from chromosome 22 to chromosome 11 in the Ewing sarcoma cells used, indicating that the breakpoint must be proximal to this locus. Moreover, we found that the chromosome 22-linked C lambda and breakpoint cluster region sequences are not translocated. This result confirms an earlier cytogenetic observation that the Ewing sarcoma-associated breakpoint in chromosome 22 is distal to those observed in translocation (8;22)-positive Burkitt lymphoma and in Philadelphia chromosome-positive chronic myeloid leukemia.

Single-cell RNA profiling identifies diverse cellular responses to EWSR1/FLI1 downregulation in Ewing sarcoma cells

2022 ◽  
Author(s):  
Roxane Khoogar ◽  
Fuyang Li ◽  
Yidong Chen ◽  
Myron Ignatius ◽  
Elizabeth R. Lawlor ◽  
...  
Keyword(s):  
Single Cell ◽  
Ewing Sarcoma ◽  
Cellular Responses ◽  
Rna Profiling ◽  
Sarcoma Cells

scholarly journals Immunostimulation by OX40 Ligand Transgenic Ewing Sarcoma Cells

2015 ◽  
Vol 5 ◽  
Author(s):  
Dajana Reuter ◽  
Martin S. Staege ◽  
Caspar D. Kühnöl ◽  
Jürgen Föll
Keyword(s):  
Ewing Sarcoma ◽  
Ox40 Ligand ◽  
Sarcoma Cells

scholarly journals Englerin A Inhibits EWS-FLI1 DNA Binding in Ewing Sarcoma Cells

2016 ◽  
Vol 291 (19) ◽  
pp. 10058-10066 ◽  
Author(s):  
Vittorio Caropreso ◽  
Emad Darvishi ◽  
Thomas J. Turbyville ◽  
Ranjala Ratnayake ◽  
Patrick J. Grohar ◽  
...  
Keyword(s):  
Dna Binding ◽  
Ewing Sarcoma ◽  
Englerin A ◽  
Sarcoma Cells

scholarly journals Gene expression changes associated with chemotherapy resistance in Ewing sarcoma cells

2018 ◽  
Author(s):  
Leonardo Horbach ◽  
Marialva Sinigaglia ◽  
Camila da Silva ◽  
Danielly Olguins ◽  
Lauro Gregianin ◽  
...  
Keyword(s):  
Gene Expression ◽  
Ewing Sarcoma ◽  
Chemotherapy Resistance ◽  
Sarcoma Cells

scholarly journals EWS-FLI1 reprograms the metabolism of Ewing sarcoma cells via positive regulation of glutamine import and serine-glycine biosynthesis

2018 ◽  
Vol 57 (10) ◽  
pp. 1342-1357 ◽  
Author(s):  
Nirmalya Sen ◽  
Allison M. Cross ◽  
Philip L. Lorenzi ◽  
Javed Khan ◽  
Berkley E. Gryder ◽  
...  
Keyword(s):  
Ewing Sarcoma ◽  
Positive Regulation ◽  
Sarcoma Cells
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