scholarly journals Genotyping analysis for the 46C/T polymorphism of coagulation factor XII and the involvement of factor XII activity in patients with recurrent pregnancy loss

2014 ◽  
Vol 106 ◽  
pp. 19-20
Author(s):  
E. Hashimoto ◽  
T. Ebara ◽  
C. Yamada-Namikawa ◽  
T. Kitaori ◽  
N. Suzumori ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Coagulation Factor ◽  
Factor Xii

scholarly journals Genotyping Analysis for the 46 C/T Polymorphism of Coagulation Factor XII and the Involvement of Factor XII Activity in Patients with Recurrent Pregnancy Loss

PLoS ONE ◽  
2014 ◽  
Vol 9 (12) ◽  
pp. e114452 ◽  
Author(s):  
Eriko Asano ◽  
Takeshi Ebara ◽  
Chisato Yamada-Namikawa ◽  
Tamao Kitaori ◽  
Nobuhiro Suzumori ◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Coagulation Factor ◽  
Factor Xii

The antigenic binding sites of autoantibodies to factor XII in patients with recurrent pregnancy losses

2008 ◽  
Vol 99 (02) ◽  
pp. 316-323 ◽  
Author(s):  
Yoshimi Fujita ◽  
Hidehiko Matsubayashi ◽  
Shun-ichiro Izumi ◽  
Mikio Mikami ◽  
Akifumi Inomo ◽  
...  
Keyword(s):  
Binding Site ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Platelet Glycoprotein ◽  
Factor Xii ◽  
Binding Studies ◽  
Amino Terminal ◽  
Recurrent Pregnancy Losses ◽  
Direct Binding ◽  
Positive Recurrent

SummaryRecently, numerous studies have suggested an association between factor XII (FXII) deficiency and recurrent pregnancy losses, and between autoantibodies to FXII and recurrent pregnancy losses. Autoantibodies to FXII rather than FXII deficiency may be a risk factor for recurrent pregnancy losses. To know the pathogenesis of autoantibodies to FXII, epitope mapping study was done. Seventeen anti-FXII antibody positive recurrent pregnancy loss patients were chosen for this study. We used synthetic peptides in inhibition and direct binding studies to identify the antigenic binding site of autoantibodies to FXII. Among plasmas from 17 recurrent pregnancy loss patients who were positive for autoantibodies to FXII, 13 patients (76.5%) recognized amino acids 1–30, the amino-terminal heavy chain region that is known as factor XII binding site to platelet glycoprotein Ibα.

Elevated coagulation factor VIII and the risk for recurrent early pregnancy loss

2004 ◽  
Vol 91 (04) ◽  
pp. 694-699 ◽  
Author(s):  
Astrid Dossenbach-Glaninger ◽  
Michael van Trotsenburg ◽  
Walter Krugluger ◽  
Martin Dossenbach ◽  
Christian Oberkanins ◽  
...  
Keyword(s):  
Factor Viii ◽  
Early Pregnancy ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Coagulation Factor ◽  
Coagulation Factor Viii ◽  
Percent Confidence Interval ◽  
Early Pregnancy Loss ◽  
Increased Risk ◽  
Recurrent Early Pregnancy Loss

SummaryInherited and acquired thrombophilia are associated with recurrent pregnancy loss. Recently, an increased risk for thromboembolic disease was described for patients with elevated coagulation factor VIII, but it is unknown whether there is also an association to early pregnancy loss. We therefore evaluated the relation between recurrent early pregnancy loss and levels of coagulation factor VIII. We enrolled 49 unrelated Caucasian women with a history of 2 6 early pregnancy losses and 48 healthy controls, who had delivered at least one term infant and had never experienced pregnancy loss. We determined factor V Leiden-, G20210A prothrombin-, MTHFR C677Tand A1298Cgene mutations, levels of antithrombin, protein C, protein S, factor VIII, C-reactive protein and antiphospholipid antibodies. There was a significantly higher rate of pregnancy losses in women with Antiphospholipid Syndrome (p = 0.043). Furthermore, plasma levels of coagulation factor VIII were significantly higher in cases than in controls (130.5 IU/dl ± 25.4 vs 119.5 IU/dl ± 24.1; p = 0.032) and appeared independent of Creactive protein (R = 0.146, p = 0.323 in cases; R = 0.028, p = 0.850 in controls). The relative risk for recurrent pregnancy loss in women with factor VIII levels above 151 IU/dl (90th percentile of controls) was 2.5 (0.7 – 8.9, 95 percent confidence interval), for levels above 156 IU/dl (95th percentile of controls) 3.9 (0.8 – 20.0, 95 percent confidence interval). Elevated maternal plasma levels of coagulation factor VIII tend to be associated with an increased risk for recurrent early pregnancy loss.

Investigating Association of Three Polymorphisms of Coagulation Factor XIII and Recurrent Pregnancy Loss

2010 ◽  
Vol 64 (3) ◽  
pp. 212-217 ◽  
Author(s):  
Mahmood Jeddi-Tehrani ◽  
Raheleh Torabi ◽  
Afsaneh Mohammadzadeh ◽  
Soheila Arefi ◽  
Mohammad Keramatipour ◽  
...  
Keyword(s):  
Factor Xiii ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Coagulation Factor ◽  
Coagulation Factor Xiii

Effects of coagulation factor XIII (Val34Leu) polymorphism on recurrent pregnancy loss in Iranian Azeri women

2017 ◽  
Vol 41 (2) ◽  
Author(s):  
Alireza Isazadeh ◽  
Saba Haj Azimian ◽  
Nazila Tariverdi ◽  
Seyed Ali Rahmani ◽  
Maryam Esmaeili ◽  
...  
Keyword(s):  
Factor Xiii ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Case Control Study ◽  
Coagulation Factor ◽  
Clotting Factor ◽  
Chain Reaction ◽  
Genotype Frequencies ◽  
Polymerase Chain ◽  
Control Study

AbstractBackground:Recurrent pregnancy loss (RPL) is a heterogeneous condition consisting of two or more consecutive abortions occurring before 20 weeks of gestation. One of the clotting factor genes encodes factor XIII (Methods:A prospective case-control study was performed on a cohort of 310 RPL patients and 290 healthy controls. DNA was extracted from the whole blood and fragments of the Val34Leu polymorphism were amplified by polymerase chain reaction (PCR), followed by DNA sequencing. Genotyping was performed using the Sequenom MassArray system.Results:The genotype frequencies ofConclusions:No significant association was observed between the Val34Leu polymorphism and RPL among Iranian Azeri women.

scholarly journals Factor XII (Hageman) Levels in Women with Recurrent Pregnancy Loss

2014 ◽  
Vol 2014 ◽  
pp. 1-3 ◽  
Author(s):  
A. Seval Ozgu-Erdinc ◽  
Cihan Togrul ◽  
Ayla Aktulay ◽  
Umran Buyukkagnici ◽  
Elif Gul Yapar Eyi ◽  
...  
Keyword(s):  
Observational Study ◽  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Referral Hospital ◽  
Retrospective Observational Study ◽  
Factor Xii ◽  
Normal Range ◽  
Tertiary Referral ◽  
Tertiary Referral Hospital ◽  
Factor Xii Deficiency

Objective. To evaluate factor XII levels in women with recurrent pregnancy loss (RPL) in a tertiary referral hospital.Methods. Women who were referred to our hospital for two consecutive abortions or three abortions in between 2007 and 2013 were included in this retrospective observational study. Women were further grouped according to factor XII levels, as <60% and ≥60%.Results. Mean factor XII level was 109.1 ± 35.7% (range: 9–200). Ninety-three (7.4%) women had factor XII levels < 60%. Mean factor XII level was 44.8 ± 13.1, and levels ranged between 9 and 60 in this group. Only one woman had factor XII level < 10 %. Remaining 1164 (92.6%) women had factor XII levels ≥ 60%. Mean factor XII level was 114.3 ± 31.7, and levels ranged between 60.3 and 200 in this group, while 1015 (72.4%) women had factor XII levels within the normal range (60%–150% [100% = 30 μg/mL]).Conclusion. Decreased activity of F-XII was diagnosed in 7.4% of women with RPL. We concluded factor XII deficiency that might be a rare but significant factor for RPL, and should be evaluated in women who are investigated for recurrent pregnancy loss.

scholarly journals H1299R in coagulation Factor V and Glu429Ala in MTHFR genes in recurrent pregnancy loss in Sari, Mazandaran

2016 ◽  
Vol 14 (5) ◽  
pp. 329-334 ◽  
Author(s):  
Nadia Arabkhazaeli ◽  
Kasra Ghanaat ◽  
Mohammad Bagher Hashemi-Soteh ◽  
◽  
◽  
...  
Keyword(s):  
Pregnancy Loss ◽  
Recurrent Pregnancy Loss ◽  
Coagulation Factor ◽  
Factor V ◽  
Coagulation Factor V
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