Proteomic profiling of rectal cancer reveals acid ceramidase is implicated in radiation response

2018 ◽  
Vol 179 ◽  
pp. 53-60 ◽  
Author(s):  
D.L. Bowden ◽  
P.A. Sutton ◽  
M.A. Wall ◽  
P.V. Jithesh ◽  
R.E. Jenkins ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Radiation Response ◽  
Proteomic Profiling ◽  
Acid Ceramidase

Acid Ceramidase As A Potential Biomarker For Locally Advanced Rectal Cancer; Is Apoptosis The Mechanism?

2019 ◽  
Vol 45 (11) ◽  
pp. 2214
Author(s):  
Rachael Clifford ◽  
Naren Govindarajah ◽  
David Bowden ◽  
Paul Sutton ◽  
Jason Parsons ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Acid Ceramidase ◽  
Potential Biomarker

Proteomic profiling of the diagnostic tumor biopsy to predict response to neoadjuvant chemoradiotherapy in rectal cancer.

2014 ◽  
Vol 32 (15_suppl) ◽  
pp. e14579-e14579
Author(s):  
Paul Anthony Sutton ◽  
Rob Jones ◽  
Bushra Hamid ◽  
Gian Abbott ◽  
Chris Goldring ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Neoadjuvant Chemoradiotherapy ◽  
Proteomic Profiling ◽  
Tumor Biopsy

scholarly journals Association of microRNA-652 Expression with Radiation Response of Colorectal Cancer: A Study from Rectal Cancer Patients in a Swedish Trial of Preoperative Radiotherapy to Public Data Analysis and in Vitro Investigation

2021 ◽  
Author(s):  
Surajit Pathak ◽  
Wen-Jian Meng ◽  
Sushmitha Sriram ◽  
Jaganmohan Reddy Jangamreddy ◽  
Antara Banerjee ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Cancer Patients ◽  
Disease Free Survival ◽  
Human Colon ◽  
Radiation Response ◽  
Human Colon Cancer ◽  
In Vitro Investigation ◽  
Public Data ◽  
Relationship Of

Abstract Purpose: Radiotherapy (RT) is a standard adjuvant therapy in progressive rectal cancer patients, but many patients are resistant to RT, leading to poor prognosis. Our study identified microRNA-652 (miR-652) value on RT response and outcome in rectal cancer patients.Methods: miR-652 expression was determined by RT-PCR in primary rectal cancer from 48 patients with and 53 patients without RT. The relationship of miR-652 with biological factors and prognosis were examined. The biological function of miR-652 was identified through TCGA and GEPIA database search. Two human colon cancer cell lines (HCT116 p53+/+ and p53-/-) were used for in vitro study. Results: miR-652 expression was augmented significantly in cancer than normal mucosa in non-RT patients (P=0.044). High miR-652 expression in non-RT patients was related to more apoptosis (P=0.036), ATM (P=0.010) and DNp73 expression (P=0.009). High miR-652 expression was related to worse disease-free survival of non-RT patients, independent of gender, age, tumor stage and differentiation (P=0.028; HR=7.398, 95% CI 0.217-3.786). The biological functional analysis further identified the prognostic value and potential relationship of miR-652 with the apoptosis in rectal cancer. In RT patients, miR-652 expression was notably decreased in cancers when compared to non-RT cases (P=0.047), and miR-652 expression in cancers was negatively related to WRAP53 expression (P=0.022). After miR-652 inhibition, the estimation of reactive oxygen species, caspase activity and apoptosis in HCT116 p53+/+ cells were significantly increased compared with HCT116 p53-/- cells after radiation.Conclusions Our findings suggest the potential value of miR-652 expression as a marker for the prediction of radiation response and clinical outcome in rectal cancer patients.

1528. Acid Ceramidase Expression and Poor Neoadjuvant Responses in Rectal Cancer - is The Modulation of Apoptosis A Key Mechanism?

2018 ◽  
Vol 44 (11) ◽  
pp. 1841-1842
Author(s):  
Narendranath Govindarajah ◽  
Rachael Clifford ◽  
Paul Sutton ◽  
David Bowden ◽  
Dale Vimalachandran ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Acid Ceramidase

Acid ceramidase: a potential biomarker for locally advanced rectal cancer

2021 ◽  
Vol 108 (Supplement_5) ◽  
Author(s):  
Rachael Elizabeth Clifford ◽  
Naren Govindarajah ◽  
David Bowden ◽  
Paul Sutton ◽  
Jason Parsons ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Acid Ceramidase ◽  
Potential Biomarker

Clinical Significance and Radiation Response of miR-302a, miR-105 and miR-888 Expression in Rectal Cancer

2018 ◽  
Author(s):  
Xiao-feng Sun ◽  
Wen-Jian Meng ◽  
Surajit Pathak ◽  
Hong Zhang ◽  
Gunnar Adell ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Clinical Significance ◽  
Radiation Response

243. High expression of acid ceramidase confers radioresistance in rectal cancer

2014 ◽  
Vol 40 (11) ◽  
pp. S99-S100
Author(s):  
P. Sutton ◽  
D. Bowden ◽  
P. Jithesh ◽  
B. Hamid ◽  
G. Abbott ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
High Expression ◽  
Acid Ceramidase

scholarly journals PINCH expression in relation to radiation response in co-cultured colon cancer cells and in rectal cancer patients

2013 ◽  
Vol 30 (5) ◽  
pp. 2097-2104 ◽  
Author(s):  
ANNICA HOLMQVIST ◽  
BIRGITTA HOLMLUND ◽  
MALIN ARDSBY ◽  
SURAJIT PATHAK ◽  
XIAO-FENG SUN
Keyword(s):  
Rectal Cancer ◽  
Colon Cancer ◽  
Cancer Cells ◽  
Cancer Patients ◽  
Radiation Response ◽  
Colon Cancer Cells
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