Acid Ceramidase As A Potential Biomarker For Locally Advanced Rectal Cancer; Is Apoptosis The Mechanism?

2019 ◽  
Vol 45 (11) ◽  
pp. 2214
Author(s):  
Rachael Clifford ◽  
Naren Govindarajah ◽  
David Bowden ◽  
Paul Sutton ◽  
Jason Parsons ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Acid Ceramidase ◽  
Potential Biomarker

Acid ceramidase: a potential biomarker for locally advanced rectal cancer

2021 ◽  
Vol 108 (Supplement_5) ◽  
Author(s):  
Rachael Elizabeth Clifford ◽  
Naren Govindarajah ◽  
David Bowden ◽  
Paul Sutton ◽  
Jason Parsons ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Acid Ceramidase ◽  
Potential Biomarker

29. Over Expression of Acid Ceramidase; Building Evidence for its Potential Use As a Biomarker for Locally Advanced Rectal Cancer

2018 ◽  
Vol 44 (11) ◽  
pp. 1839-1840
Author(s):  
Rachael Clifford ◽  
Naren Govindarajah ◽  
David Bowden ◽  
Paul Sutton ◽  
Jason Parsons ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Acid Ceramidase ◽  
Over Expression ◽  
Potential Use

scholarly journals MRI Radiomics Signature as a Potential Biomarker for Predicting KRAS Status in Locally Advanced Rectal Cancer Patients

2021 ◽  
Vol 11 ◽  
Author(s):  
ZhiYuan Zhang ◽  
LiJun Shen ◽  
Yan Wang ◽  
Jiazhou Wang ◽  
Hui Zhang ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Characteristic Curve ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Image Features ◽  
Lasso Regression ◽  
Wild Type ◽  
Potential Biomarker ◽  
T2 Mri

Background and PurposeLocally advanced rectal cancer (LARC) is a heterogeneous disease with little information about KRAS status and image features. The purpose of this study was to analyze the association between T2 magnetic resonance imaging (MRI) radiomics features and KRAS status in LARC patients.Material and MethodsEighty-three patients with KRAS status information and T2 MRI images between 2012.05 and 2019.09 were included. Least absolute shrinkage and selection operator (LASSO) regression was performed to assess the associations between features and gene status. The patients were divided 7:3 into training and validation sets. The C-index and the average area under the receiver operator characteristic curve (AUC) were used for performance evaluation.ResultsThe clinical characteristics of 83 patients in the KRAS mutant and wild-type cohorts were balanced. Forty-two (50.6%) patients had KRAS mutations, and 41 (49.4%) patients had wild-type KRAS. A total of 253 radiomics features were extracted from the T2-MRI images of LARC patients. One radiomic feature named X.LL_scaled_std, a standard deviation value of scaled wavelet-transformed low-pass channel filter, was selected from 253 features (P=0.019). The radiomics-based C-index values were 0.801 (95% CI: 0.772-0.830) and 0.703 (95% CI: 0.620-0.786) in the training and validation sets, respectively.ConclusionRadiomics features could differentiate KRAS status in LARC patients based on T2-MRI images. Further validation in a larger dataset is necessary in the future.

1580. Does Pharmacological Inhibition of Acid Ceramidase Improve Radiosensitivity for Locally Advanced Rectal Cancer?

2018 ◽  
Vol 44 (11) ◽  
pp. 1834
Author(s):  
Rachael Clifford ◽  
Naren Govindarajah ◽  
David Bowden ◽  
Paul Sutton ◽  
Jason Parsons ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Locally Advanced ◽  
Advanced Rectal Cancer ◽  
Locally Advanced Rectal Cancer ◽  
Acid Ceramidase ◽  
Pharmacological Inhibition

scholarly journals Evaluation of Tissue and Circulating miR-21 as Potential Biomarker of Response to Chemoradiotherapy in Rectal Cancer

2020 ◽  
Vol 13 (9) ◽  
pp. 246
Author(s):  
Susana Ourô ◽  
Cláudia Mourato ◽  
Marisa P. Ferreira ◽  
Diogo Albergaria ◽  
André Cardador ◽  
...  
Keyword(s):  
Rectal Cancer ◽  
Tumor Tissue ◽  
Statistical Significance ◽  
Locally Advanced ◽  
Predictive Biomarkers ◽  
Advanced Rectal Cancer ◽  
Recurrence Risk ◽  
Locally Advanced Rectal Cancer ◽  
Plasma Biomarker ◽  
Potential Biomarker

Response to chemoradiotherapy (CRT) in patients with locally advanced rectal cancer (RC) is quite variable and it is urgent to find predictive biomarkers of response. We investigated miR-21 as tissue and plasma biomarker of response to CRT in a prospective cohort of RC patients; The expression of miR-21 was analyzed in pre- and post-CRT rectal tissue and plasma in 37 patients with RC. Two groups were defined: Pathological responders (TRG 0, 1 and 2) and non-responders (TRG 3). The association between miR-21, clinical and oncological outcomes was assessed; miR-21 was upregulated in tumor tissue and we found increased odds of overexpression in pre-CRT tumor tissue (OR: 1.63; 95% CI: 0.40–6.63, p = 0.498) and pre-CRT plasma (OR: 1.79; 95% CI: 0.45–7.19, p = 0.414) of non-responders. The overall recurrence risk increased with miR-21 overexpression in pre-CRT tumor tissue (HR: 2.175, p = 0.37); Significantly higher miR-21 expression is observed in tumor tissue comparing with non-neoplastic. Increased odds of non-response is reported in patients expressing higher miR-21, although without statistical significance. This is one of the first studies on circulating miR-21 as a potential biomarker of response to CRT in RC patients.

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