Proteomic analysis of pancreatic cancer stem cells: Functional role of fatty acid synthesis and mevalonate pathways

2017 ◽  
Vol 150 ◽  
pp. 310-322 ◽  
Author(s):  
Jessica Brandi ◽  
Ilaria Dando ◽  
Elisa Dalla Pozza ◽  
Giulia Biondani ◽  
Rosalind Jenkins ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Fatty Acid ◽  
Cancer Stem Cells ◽  
Fatty Acid Synthesis ◽  
Proteomic Analysis ◽  
Functional Role ◽  
Acid Synthesis ◽  
Pancreatic Cancer Stem Cells

scholarly journals Integrated lipidomics and proteomics reveal cardiolipin alterations, upregulation of HADHA and long chain fatty acids in pancreatic cancer stem cells

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Claudia Di Carlo ◽  
Bebiana C. Sousa ◽  
Marcello Manfredi ◽  
Jessica Brandi ◽  
Elisa Dalla Pozza ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Fatty Acid ◽  
Cancer Stem Cells ◽  
Acyl Chain ◽  
Fatty Acid Elongase ◽  
Acyl Chains ◽  
A Chain ◽  
Pancreatic Cancer Stem Cells ◽  
Long Chain

AbstractPancreatic cancer stem cells (PCSCs) play a key role in the aggressiveness of pancreatic ductal adenocarcinomas (PDAC); however, little is known about their signaling and metabolic pathways. Here we show that PCSCs have specific and common proteome and lipidome modulations. PCSCs displayed downregulation of lactate dehydrogenase A chain, and upregulation of trifunctional enzyme subunit alpha. The upregulated proteins of PCSCs are mainly involved in fatty acid (FA) elongation and biosynthesis of unsaturated FAs. Accordingly, lipidomics reveals an increase in long and very long-chain unsaturated FAs, which are products of fatty acid elongase-5 predicted as a key gene. Moreover, lipidomics showed the induction in PCSCs of molecular species of cardiolipin with mixed incorporation of 16:0, 18:1, and 18:2 acyl chains. Our data indicate a crucial role of FA elongation and alteration in cardiolipin acyl chain composition in PCSCs, representing attractive therapeutic targets in PDAC.

scholarly journals The Role of miRNAs in the Regulation of Pancreatic Cancer Stem Cells

2016 ◽  
Vol 2016 ◽  
pp. 1-7 ◽  
Author(s):  
Sabrina Bimonte ◽  
Antonio Barbieri ◽  
Maddalena Leongito ◽  
Giuseppe Palma ◽  
Vitale del Vecchio ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Drug Resistance ◽  
Cancer Stem Cells ◽  
Biological Activities ◽  
Biological Properties ◽  
Ductal Adenocarcinoma ◽  
Small Noncoding Rnas ◽  
Pancreatic Cancer Stem Cells

Pancreatic ductal adenocarcinoma is currently one of the deadliest cancers with low overall survival rate. This disease leads to an aggressive local invasion and early metastases and is poorly responsive to treatment with chemotherapy or chemoradiotherapy. Several studies have shown that pancreatic cancer stem cells (PCSCs) play different roles in the regulation of drug resistance and recurrence in pancreatic cancer. MicroRNA (miRNA), a class of newly emerging small noncoding RNAs, is involved in the modulation of several biological activities ranging from invasion to metastases development, as well as drug resistance of pancreatic cancer. In this review, we synthesize the latest findings on the role of miRNAs in regulating different biological properties of pancreatic cancer stem cells.

scholarly journals Role of Dietary Cancer-Preventive Phytochemicals in Pancreatic Cancer Stem Cells

2018 ◽  
Vol 4 (4) ◽  
pp. 326-335 ◽  
Author(s):  
Gaurav Kumar ◽  
Mudassir Farooqui ◽  
Chinthalapally V. Rao
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Pancreatic Cancer Stem Cells

Abstract B18: Defining the role of chromatin remodeling complexes in pancreatic cancer stem cells

2019 ◽  
Author(s):  
Lesley Paige Ferguson ◽  
Jovylyn Gatchalian ◽  
Nikki K. Lytle ◽  
Nirakar Rajbhandari ◽  
Kendall Chambers ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Chromatin Remodeling ◽  
Chromatin Remodeling Complexes ◽  
Pancreatic Cancer Stem Cells

scholarly journals Exploring the functional role of an ancient mitochondrial fatty acid synthesis pathway

2019 ◽  
Vol 33 (S1) ◽  
Author(s):  
Katja K Dove ◽  
Malika F Kadirova ◽  
Sara M Nowinski ◽  
Yeyun Ouyang ◽  
Jon G Van Vranken ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Fatty Acid Synthesis ◽  
Functional Role ◽  
Acid Synthesis ◽  
Fatty Acid Synthesis Pathway ◽  
Mitochondrial Fatty Acid

scholarly journals Novel role of O-glycosyltransferases GALNT3 and B3GNT3 in the self-renewal of pancreatic cancer stem cells

BMC Cancer ◽  
2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Srikanth Barkeer ◽  
Seema Chugh ◽  
Saswati Karmakar ◽  
Garima Kaushik ◽  
Sanchita Rauth ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
The Self ◽  
Self Renewal ◽  
Pancreatic Cancer Stem Cells

Role of mitochondrial dynamics in pancreatic cancer stem cells

Pancreatology ◽  
2020 ◽  
Vol 20 (8) ◽  
pp. e22
Author(s):  
S. Courtois ◽  
B. De Luxán-Delgado ◽  
L. Penin-Peyta ◽  
A. Royo-García ◽  
B. Parejo-Alonso ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Stem Cells ◽  
Cancer Stem Cells ◽  
Mitochondrial Dynamics ◽  
Pancreatic Cancer Stem Cells
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