Proteomic analysis of the crayfish gastrolith chitinous extracellular matrix reveals putative protein complexes and a central role for GAP 65

2015 ◽  
Vol 128 ◽  
pp. 333-343 ◽  
Author(s):  
Lilah Glazer ◽  
Ziv Roth ◽  
Simy Weil ◽  
Eliahu D. Aflalo ◽  
Isam Khalaila ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Proteomic Analysis ◽  
Protein Complexes ◽  
Putative Protein

scholarly journals Upstream – News in Genomics

2002 ◽  
Vol 3 (3) ◽  
pp. 221-225
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Ovarian Cancer ◽  
Oryza Sativa ◽  
Schizosaccharomyces Pombe ◽  
Fission Yeast ◽  
Proteomic Analysis ◽  
Large Scale ◽  
Protein Complexes ◽  
The Other ◽  
Blood Samples

In recent months a bumper crop of genomes has been completed, including the fission yeast (Schizosaccharomyces pombe) and rice (Oryza sativa). Two large-scale studies ofSaccharomyces cerevisiaeprotein complexes provided a picture of the eukaryotic proteome as a network of complexes. Amongst the other stories of interest was a demonstration that proteomic analysis of blood samples can be used to detect ovarian cancer, perhaps even as early as stage I.

Proteomic analysis of protein complexes

PROTEOMICS ◽  
2007 ◽  
Vol 7 (16) ◽  
pp. 2688-2697 ◽  
Author(s):  
Ming Zhou ◽  
Timothy D. Veenstra
Keyword(s):  
Proteomic Analysis ◽  
Protein Complexes

scholarly journals Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver

2012 ◽  
Vol 11 (8) ◽  
pp. 4052-4064 ◽  
Author(s):  
S. Tamir Rashid ◽  
Jonathan D. Humphries ◽  
Adam Byron ◽  
Ameet Dhar ◽  
Janet A. Askari ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Cell Line ◽  
Hepatic Stellate Cell ◽  
Proteomic Analysis ◽  
Stellate Cell ◽  
Fibrotic Liver

scholarly journals Particulate kidney extracellular matrix: bioactivity and proteomic analysis of a novel scaffold from porcine origin

2021 ◽  
Vol 9 (1) ◽  
pp. 186-198
Author(s):  
Rita Sobreiro-Almeida ◽  
Maria Elena Melica ◽  
Laura Lasagni ◽  
Hugo Osório ◽  
Paola Romagnani ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Growth Factors ◽  
Proteomic Analysis ◽  
Native Tissue ◽  
Novel Scaffold ◽  
Porcine Origin

Decellularized matrices are attractive substrates, being able to retain growth factors and proteins present in the native tissue.

Comparative proteomic analysis of extracellular matrix proteins secreted by two types of skin fibroblasts

PROTEOMICS ◽  
2006 ◽  
Vol 6 (21) ◽  
pp. 5868-5879 ◽  
Author(s):  
Delphine Pflieger ◽  
Sandrine Chabane ◽  
Olivier Gaillard ◽  
Bruno Alain Bernard ◽  
Patrick Ducoroy ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Proteomic Analysis ◽  
Extracellular Matrix Proteins ◽  
Skin Fibroblasts ◽  
Matrix Proteins ◽  
Comparative Proteomic Analysis

scholarly journals Glycosaminoglycan–Protein Interactions: The First Draft of the Glycosaminoglycan Interactome

2020 ◽  
pp. 002215542094640 ◽  
Author(s):  
Sylvain D. Vallet ◽  
Olivier Clerc ◽  
Sylvie Ricard-Blum
Keyword(s):  
Extracellular Matrix ◽  
Protein Interactions ◽  
Dermatan Sulfate ◽  
Protein Complexes ◽  
Keratan Sulfate ◽  
Protein Interaction Networks ◽  
Interaction Networks ◽  
Matrix Proteins ◽  
Matrix Assembly ◽  
Gag Protein

The six mammalian glycosaminoglycans (GAGs), chondroitin sulfate, dermatan sulfate, heparin, heparan sulfate, hyaluronan, and keratan sulfate, are linear polysaccharides. Except for hyaluronan, they are sulfated to various extent, and covalently attached to proteins to form proteoglycans. GAGs interact with growth factors, morphogens, chemokines, extracellular matrix proteins and their bioactive fragments, receptors, lipoproteins, and pathogens. These interactions mediate their functions, from embryonic development to extracellular matrix assembly and regulation of cell signaling in various physiological and pathological contexts such as angiogenesis, cancer, neurodegenerative diseases, and infections. We give an overview of GAG–protein interactions (i.e., specificity and chemical features of GAG- and protein-binding sequences), and review the available GAG–protein interaction networks. We also provide the first comprehensive draft of the GAG interactome composed of 832 biomolecules (827 proteins and five GAGs) and 932 protein–GAG interactions. This network is a scaffold, which in the future should integrate structures of GAG–protein complexes, quantitative data of the abundance of GAGs in tissues to build tissue-specific interactomes, and GAG interactions with metal ions such as calcium, which plays a major role in the assembly of the extracellular matrix and its interactions with cells. This contextualized interactome will be useful to identify druggable GAG–protein interactions for therapeutic purpose:

scholarly journals Prostate cancer serum biomarker discovery through proteomic analysis of alpha-2 macroglobulin protein complexes

2008 ◽  
Vol 2 (9) ◽  
pp. 1223-1233 ◽  
Author(s):  
Earle F. Burgess ◽  
Amy-Joan L. Ham ◽  
David L. Tabb ◽  
Dean Billheimer ◽  
Bruce J. Roth ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Proteomic Analysis ◽  
Biomarker Discovery ◽  
Protein Complexes ◽  
Serum Biomarker

scholarly journals iTRAQ proteomic analysis of extracellular matrix remodeling in aortic valve disease

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Tatiana Martin-Rojas ◽  
Laura Mourino-Alvarez ◽  
Sergio Alonso-Orgaz ◽  
Esther Rosello-Lleti ◽  
Enrique Calvo ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Aortic Valve ◽  
Proteomic Analysis ◽  
Aortic Valve Disease ◽  
Valve Disease ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling
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