scholarly journals Exercise has a positive effect on low-grade inflammation in women with breast cancer [synopsis]

2016 ◽  
Vol 62 (4) ◽  
pp. 227
Author(s):  
Nicholas Taylor
Keyword(s):  
Breast Cancer ◽  
Low Grade ◽  
Low Grade Inflammation ◽  
Positive Effect

scholarly journals Lactobacillus Rhamnosus GG Affects the BDNF System in Brain Samples of Wistar Rats with Pepsin-Trypsin-Digested Gliadin (PTG)-Induced Enteropathy

Nutrients ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 629
Author(s):  
Antonella Orlando ◽  
Guglielmina Chimienti ◽  
Angela Maria Serena Lezza ◽  
Vito Pesce ◽  
Isabella Gigante ◽  
...  
Keyword(s):  
Nervous System ◽  
Adaptive Response ◽  
Wistar Rats ◽  
Lactobacillus Rhamnosus ◽  
Low Grade ◽  
Lactobacillus Rhamnosus Gg ◽  
Curative Effect ◽  
Low Grade Inflammation ◽  
The Brain ◽  
Positive Effect

Celiac disease (CD) presents as chronic low-grade inflammation of the small intestine often characterized by psychiatric comorbidities. The brain-derived neurotrophic factor (BDNF), which we have shown to be reduced in the serum of CD patients, acts as the bridge between immune activation and the nervous system adaptive response. Since Lactobacillus has been shown to upregulate BDNF, this study aimed to evaluate whether the administration of Lactobacillus rhamnosus GG (L.GG) could positively affect the brain BDNF system in rats mimicking the CD lesions. Data have shown that the administration of pepsin-trypsin digested gliadin (PTG) and L.GG alter the levels of mature BDNF (mBDNF), as evaluated by Western blotting. PTG provoked a reduction of mBDNF compared to controls, and a compensatory increase of its receptor TrkB. L.GG induced a slight positive effect on mBDNF levels under normal conditions, while it was able to rescue the PTG-induced reduced expression of mBDNF. The curative effect of L.GG was finely tuned, accompanied by the reduction of TrkB, probably to avoid the effect of excessive BDNF.

scholarly journals Association Between the Use of a Mobile Health Strategy App and Biological Changes in Breast Cancer Survivors: Prospective Pre-Post Study

10.2196/15062 ◽  
2019 ◽  
Vol 21 (8) ◽  
pp. e15062 ◽  
Author(s):  
Mario Lozano-Lozano ◽  
Lucia Melguizo-Rodríguez ◽  
Carolina Fernández-Lao ◽  
Noelia Galiano-Castillo ◽  
Irene Cantarero-Villanueva ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Quality Of Life ◽  
Energy Balance ◽  
Breast Cancer Survivors ◽  
Low Grade ◽  
Tumor Removal ◽  
Risk Of Cancer ◽  
Low Grade Inflammation ◽  
Predictors Of Change

Background There is a bidirectional relationship between chronic low-grade inflammation and cancer. Inflammatory markers, such as interleukin-6 (IL-6), have been associated with both the malignant transformation of epithelial cells and tumor progression, thus linking low-grade inflammation with a higher risk of cancer and recurrence in the survival phase. Therefore, they are considered valuable prognostic biomarkers. Knowing and finding appropriate primary prevention strategies to modify these parameters is a major challenge in reducing the risk of cancer recurrence and increasing survival. Different therapeutic strategies have shown efficacy in the modification of these and other biological parameters, but with contradictory results. There are apparently no strategies in which telemedicine, and specifically mobile health (mHealth), are used as a means to potentially cause biological changes. Objective The objectives of this study were to: (1) check whether it is feasible to find changes in inflammation biomarkers through an mHealth strategy app as a delivery mechanism of an intervention to monitor energy balance; and (2) discover potential predictors of change of these markers in breast cancer survivors (BCSs). Methods A prospective quasi-experimental pre-post study was conducted through an mHealth energy balance monitoring app with 73 BCSs, defined as stage I-IIIA of breast cancer and at least six months from the completion of the adjuvant therapy. Measurements included were biological salivary markers (IL-6 and C-reactive protein [CRP]), self-completed questionnaires (the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core 30, the user version of the Mobile Application Rating Scale [uMARS] and an ad hoc clinical and sociodemographic questionnaire) and physical objective measures (accelerometry, weight and height). In addition, using the logging data of the mHealth app, the rate of use (in days) was recorded during the entire experimental phase of the study. Using Stata software, a paired two-tailed t test, Pearson and Spearman correlations, and a stepwise multiple regression analysis were used to interpret the data. Results Analyzing changes in inflammatory biomarker concentrations after using the mHealth app, differences between preassessment CRP (4899.04 pg/ml; SD 1085.25) and IL-6 (87.15 pg/ml; SD 33.59) and postassessment CRP (4221.24 pg/ml; SD 911.55) and IL-6 (60.53 pg/ml; SD 36.31) showed a significant decrease in both markers, with a mean difference of –635.25 pg/ml (95% CI –935.65 to –334.85; P<.001) in CRP and –26.61 pg/ml (95% CI –42.51 to –10.71; P=.002) in IL-6. Stepwise regression analyses revealed that changes in global quality of life, as well as uMARS score and hormonal therapy, were possible predictors of change in CRP concentration after using the mHealth app. In the same way, the type of tumor removal surgery conducted, as well as changes in weight and pain score, were possible predictors of change in IL-6 concentration after using the app. Conclusions In conclusion, through the results of this study, we hypothesize that there is a possible association between an mHealth energy balance monitoring strategy and biological changes in BCSs. These changes could be explained by different biopsychosocial parameters, such as the use of the application itself, quality of life, pain, type of tumor removal surgery, hormonal treatment or obesity.

Low-grade inflammation and exercise training in women with breast cancer: A meta-analysis with meta-regression.

2015 ◽  
Vol 33 (15_suppl) ◽  
pp. e12581-e12581
Author(s):  
Jose F Meneses-Echavez ◽  
Robinson Ramirez-Velez ◽  
Jorge Enrique Correa Bautista
Keyword(s):  
Breast Cancer ◽  
Exercise Training ◽  
Meta Analysis ◽  
Low Grade ◽  
Meta Regression ◽  
Low Grade Inflammation

Exercise training, inflammatory cytokines, and other markers of low-grade inflammation in breast cancer survivors: A systematic review and meta-analysis.

2014 ◽  
Vol 32 (26_suppl) ◽  
pp. 121-121 ◽  
Author(s):  
Jose F Meneses-Echavez ◽  
Robinson Ramirez-Velez ◽  
Emilio Gonzalez-Jimenez ◽  
Jacqueline Schmidt Rio-Valle ◽  
Maria Jose Sanchez Perez ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Exercise Training ◽  
Cancer Survivors ◽  
Breast Cancer Survivors ◽  
Serum Levels ◽  
Low Grade ◽  
Exercise Interventions ◽  
Randomized Controlled ◽  
Tnf Α ◽  
Low Grade Inflammation

121 Background: Low-grade inflammation, characterized by high cytokine activity, plays a crucial role in tumorigenesis. Further, cytokines and other inflammatory biomarkers are closely implicated in tumor growth, angiogenesis, and metastasis. This metaanalysis of randomized controlled trials estimates the effects of exercise training in the control of the serum levels of cytokines and other inflammatory markers in breast cancer survivors. Methods: PRISMA statement and the Cochrane Handbook were followed. We searched MEDLINE, CENTRAL, EMBASE, Scopus and DARE database to retrieve randomized controlled trials published between 1980- March 2014 providing effect estimates of exercise interventions in the serum levels of cytokines, such as interleukin (IL) -2, IL-6, IL-8, tumoral necrosis factor alpha (TNF-α) and C-reactive protein (CRP) in breast cancer survivors. An Inverse of variance (IV) fixed-effects model was conducted in absence of heterogeneity (I2<50%); otherwise a random-effects model was selected. Mean Differences (MD) were calculated to estimate differences between groups (p<0.05 with 95% Confidence interval). Heterogeneity was measured with the Chi2 test (p<0.10) and I2 statistics. Results: A total of 15 studies were included (n=1,447; mean age= 51.6 years old). Exercise interventions resulted in positive effects for CRP (MD= 0.37, 95%CI, 0.04 to 0.71; p= 0.03; I2=15%), IL-2 (MD= -6.04, 85%CI, -11.41 to -0.67; p=0.03; I2=0%), IL-10 (-22.90, 95%CI, -41.27 to -4.53; p=0.001, I2=0%) and waist circumference as indicator of body composition (MD= -1.12, 95%CI, -2.06 to -0.18; p=0.02; I2=45%). Non-significant differences were observed for IL-6 and TNF-α. There was no evidence of publication bias. Conclusions: These findings suggest that exercise training improves the systemic pro-inflammatory profile in breast cancer survivors and consequently the immunological responses and the carcinogenic processes related to tumoral environment. The effects observed for IL-10 provide a novel focus of evidence for the role of exercise as an effective anti-inflammatory intervention in cancer survivors.

scholarly journals Dietary sulfate-driven and gut dysbiosis-triggered breast cancer-related gene upregulation

2018 ◽  
Author(s):  
CHEN YanPingf ◽  
LIAO Tao ◽  
TAN LiLi ◽  
CHEN DongMei ◽  
XU Qin ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gut Microbiota ◽  
Individual Difference ◽  
Suppressor Gene ◽  
Low Grade ◽  
Ki 67 ◽  
Cancer Related Gene ◽  
The Individual ◽  
Low Grade Inflammation ◽  
Gut Microbiota Dysbiosis

AbstractBy gut microbiota metagenomic analysis, we found that the abundance of sulfatase-secreting bacteria (SSB) in the gut of mice fed chondroitin sulfate (CS) increases with significant individual difference. The fluctuation of lipopolysaccharide (LPS) and pro-inflammatory indicators with significant individual and tissue variations was also observed. After mice were fed mixed with CS or injected separately with LPS, the breast cancer-related transcriptional factor genes, BCL11A and RUNX1, were upregulated, whereas the tumor suppressor gene, TP53BP1, were downregulated. Further, the mammary myopithelium marker CK5/6, the mammary hyperplasia marker Ki-67, and other tumor markers were also upregulated. While the exogenous estradiol does not induce the expression of BCL11A, RUNX1, and TP53BP1, the estrogen receptor (ER) agonist Fulvestrant that mimics estradiol action not only elevates estradiol concentrations, but also upregulates tumor marker expression levels, revealing that ER inflammatory inactivation and hyperestrogenemia induction might be the etiological cues of breast cancer origin. This study has preliminarily established a possible correlation of gut microbiota dysbiosis and chronic low-grade inflammation with the early-phase onset of breast cancer in mice. The statistical insignificance of test data was attributed to the individual difference of gut microbiota compositions, which determining the individual and tissue variations of systemic inflammation.

Obesity and the gut microbiome: pathophysiological aspects

2014 ◽  
Vol 17 (1) ◽  
Author(s):  
H. Leon Bradlow
Keyword(s):  
Breast Cancer ◽  
Gut Microbiome ◽  
Deoxycholic Acid ◽  
Obese Individual ◽  
The Body ◽  
Sex Steroid ◽  
Low Grade ◽  
The Past ◽  
Metabolic Role ◽  
Low Grade Inflammation

AbstractWhile there is a large volume of literature describing a role for obesity as a risk factor for breast cancer and many other cancers, in the main a causal relationship has not been established. If the study is limited to breast cancer risk, it has been suggested that the increase in sex steroid formation that occurs in postmenopausal women plays a role. Obesity is known to be associated with chronic low grade inflammation, but no reason for this association has been offered in the past. The gut microbiome, while known to be enormous, has not in the past been considered as a metabolic role player in the body. This is now recognized to be the case. Recent studies have found the obesity is correlated with an alteration in the gut microbiome. In obese individual there is a change in the relative proportions of the two major classes of bacteria – bacteroides and firmacutes – with the latter dominant in obesity and resulting in the formation of increased amounts of metabolic endotoxins like deoxycholic acid and lipopolysaccharides (LPS). Obese individuals show a decrease in the concentration of

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