scholarly journals Levodopa acts centrally to induce an antinociceptive action against colonic distension through activation of D2 dopamine receptors and the orexinergic system in the brain in conscious rats

2016 ◽  
Vol 130 (2) ◽  
pp. 123-127 ◽  
Author(s):  
Toshikatsu Okumura ◽  
Tsukasa Nozu ◽  
Shima Kumei ◽  
Kaoru Takakusaki ◽  
Saori Miyagishi ◽  
...  
Keyword(s):  
Dopamine Receptors ◽  
D2 Dopamine Receptors ◽  
Antinociceptive Action ◽  
Conscious Rats ◽  
Colonic Distension ◽  
The Brain

scholarly journals Heterodimeric D1-D2 dopamine receptors: a review

2017 ◽  
Vol 63 (1) ◽  
pp. 5-12 ◽  
Author(s):  
N.L. Vekshina ◽  
P.K. Anokhin ◽  
A.G. Veretinskaya ◽  
I.Yu. Shamakina
Keyword(s):  
Dopamine Receptors ◽  
Functional Significance ◽  
Drug Targets ◽  
Addiction Treatment ◽  
Current Knowledge ◽  
D2 Dopamine Receptors ◽  
Receptor Interactions ◽  
Drug Addiction Treatment ◽  
The Brain ◽  
Structure And Functions

This review summarizes modern data on the structure and functions ofheteromersformed by D1 and D2 dopamine receptors focusing on their role in the mechanisms of drug dependence. This article discusses potential functional significance of heterodimeric D1-D2 dopamine receptorsdue to their localization in the brain as well as unique pharmacological propertiesversus constituent monomers. It is shown that heteromerization results in dramatic changes in activated signaling pathways compare to the corresponding monomers. These studies update our current knowledge of ligand-receptor interactions and provide better understanding of dopamine receptors pharmacology. Furthermore elucidation of significance of heterodimeric D1-D2 dopamine receptors as drug targets is important for the development of new effective drug addiction treatment.

scholarly journals Antinociceptive action against colonic distension by brain orexin in conscious rats

2015 ◽  
Vol 1598 ◽  
pp. 12-17 ◽  
Author(s):  
Toshikatsu Okumura ◽  
Tsukasa Nozu ◽  
Shima Kumei ◽  
Kaoru Takakusaki ◽  
Saori Miyagishi ◽  
...  
Keyword(s):  
Antinociceptive Action ◽  
Conscious Rats ◽  
Colonic Distension

Involvement of the dopaminergic system in the central orexin-induced antinociceptive action against colonic distension in conscious rats

2015 ◽  
Vol 605 ◽  
pp. 34-38 ◽  
Author(s):  
Toshikatsu Okumura ◽  
Tsukasa Nozu ◽  
Shima Kumei ◽  
Kaoru Takakusaki ◽  
Saori Miyagishi ◽  
...  
Keyword(s):  
Dopaminergic System ◽  
Antinociceptive Action ◽  
Conscious Rats ◽  
Colonic Distension
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