Ghrelin acts centrally to induce an antinociceptive action during colonic distension through the orexinergic, dopaminergic and opioid systems in conscious rats

2018 ◽  
Vol 1686 ◽  
pp. 48-54 ◽  
Author(s):  
Toshikatsu Okumura ◽  
Tsukasa Nozu ◽  
Shima Kumei ◽  
Kaoru Takakusaki ◽  
Masumi Ohhira
Keyword(s):  
Antinociceptive Action ◽  
Conscious Rats ◽  
Colonic Distension ◽  
Opioid Systems

scholarly journals Antinociceptive action against colonic distension by brain orexin in conscious rats

2015 ◽  
Vol 1598 ◽  
pp. 12-17 ◽  
Author(s):  
Toshikatsu Okumura ◽  
Tsukasa Nozu ◽  
Shima Kumei ◽  
Kaoru Takakusaki ◽  
Saori Miyagishi ◽  
...  
Keyword(s):  
Antinociceptive Action ◽  
Conscious Rats ◽  
Colonic Distension

Involvement of the dopaminergic system in the central orexin-induced antinociceptive action against colonic distension in conscious rats

2015 ◽  
Vol 605 ◽  
pp. 34-38 ◽  
Author(s):  
Toshikatsu Okumura ◽  
Tsukasa Nozu ◽  
Shima Kumei ◽  
Kaoru Takakusaki ◽  
Saori Miyagishi ◽  
...  
Keyword(s):  
Dopaminergic System ◽  
Antinociceptive Action ◽  
Conscious Rats ◽  
Colonic Distension

scholarly journals Centrally Administered Tuberoinfundibular Peptide of 39 Residues Inhibits Arginine Vasopressin Release in Conscious Rats

Endocrinology ◽  
2003 ◽  
Vol 144 (7) ◽  
pp. 2791-2796 ◽  
Author(s):  
Yoshihisa Sugimura ◽  
Takashi Murase ◽  
Seiji Ishizaki ◽  
Kazushige Tachikawa ◽  
Hiroshi Arima ◽  
...  
Keyword(s):  
Arginine Vasopressin ◽  
Maximum Effect ◽  
Intracerebroventricular Injection ◽  
Inhibitory Effects ◽  
Endogenous Ligand ◽  
Vasopressin Release ◽  
Conscious Rats ◽  
Tuberoinfundibular Peptide ◽  
The Brain ◽  
Opioid Systems

Abstract Tuberoinfundibular peptide of 39 residues (TIP39) is a recently discovered neuropeptide identified on the basis of its ability to activate the PTH2 receptor, and it is thought to be the brain PTH2 receptor’s endogenous ligand. The PTH2 receptor is highly expressed in the hypothalamus, suggesting a role in the modulation of neuroendocrinological functions. PTHrP, which also belongs to the PTH-related peptides family, stimulates arginine vasopressin (AVP) release. In the present study, therefore, we investigated the effect of centrally administered TIP39 on AVP release in conscious rats. Intracerebroventricular administration of TIP39 (10–500 pmol/rat) significantly suppressed the plasma AVP concentration in dehydrated rats, and the maximum effect was obtained 5 min after administration (dehydration with 100 pmol/rat TIP39, 4.32 ± 1.17 pg/ml; vs. control, 8.21 ± 0.70 pg/ml). The plasma AVP increase in response to either hyperosmolality [ip injection of hypertonic saline (HS), 600 mosmol/kg] or hypovolemia [ip injection of polyethylene glycol (PEG)] was also significantly attenuated by an intracerebroventricular injection of TIP39 (HS with 100 pmol/rat TIP39, 2.65 ± 0.52 pg/ml; vs. HS alone, 4.69 ± 0.80 pg/ml; PEG with 100 pmol/rat TIP39, 4.10 ± 0.79 pg/ml; vs. PEG alone, 6.19 ± 0.34 pg/ml). Treatment with naloxone [1.5 mg/rat, sc injection], a nonselective opioid receptor antagonist, significantly reversed the inhibitory effects of TIP39 on AVP release. These results suggest that central TIP39 plays an inhibitory role in the osmoregulation and baroregulation of AVP release and that intrinsic opioid systems are involved in its mechanism.

Pinaverium bromide prevents visceral pain induced by colonic distension

2001 ◽  
Vol 120 (5) ◽  
pp. A399-A399
Author(s):  
V LERAY ◽  
V SINNIGER ◽  
B ROCHE ◽  
M ODILECHRISTEN ◽  
S PHARMA ◽  
...  
Keyword(s):  
Visceral Pain ◽  
Colonic Distension ◽  
Pinaverium Bromide

Relaxin is a potent renal vasodilator in conscious rats

1998 ◽  
Vol 5 (1) ◽  
pp. 146A-146A
Author(s):  
L DANIELSON ◽  
O SHERWOOD ◽  
K CONRAD
Keyword(s):  
Conscious Rats
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