Forced degradation study of racecadotril: Effect of co-solvent, characterization of degradation products by UHPLC-Q-TOF-MS/MS, NMR and cytotoxicity assay

2016 ◽  
Vol 128 ◽  
pp. 9-17 ◽  
Author(s):  
Vishnuvardhan Chiguru ◽  
Allakonda Lingesh ◽  
Srinivas R. ◽  
Satheeshkumar N.
Keyword(s):  
Degradation Products ◽  
Cytotoxicity Assay ◽  
Forced Degradation ◽  
Degradation Study ◽  
Tof Ms

Synthesis and Characterization of Potential and Degraded Impurities of Regadenoson

2020 ◽  
Vol 16 (8) ◽  
pp. 1130-1139
Author(s):  
Singaram Sathiyanarayanan ◽  
Chidambaram Subramanian Venkatesan ◽  
Senthamaraikannan Kabilan
Keyword(s):  
Mass Spectra ◽  
Degradation Products ◽  
Hplc Method ◽  
Forced Degradation ◽  
Spectroscopic Techniques ◽  
A2a Adenosine Receptor ◽  
Degradation Study ◽  
Related Substances ◽  
Adenosine Receptor Agonist

Background: Regadenoson is an A2A adenosine receptor agonist that is a coronary vasodilator and commonly used as a pharmacologic cardiac stressing agents. Methods: HPLC method was used for the analysis of related substances. The degraded impurities during the process were isolated and characterized by IR, Mass and NMR spectral analysis. Results: Forced degradation study of regadenoson under conditions of hydrolysis (neutral, acidic and alkaline) and oxidations suggested in the ICH Q1A(R2) was accomplished. The drug showed significant degradation under all the above conditions. On the whole, five novel degradation products were found under diverse conditions along with process related impurities which were not reported earlier. Conclusion: All the degradation products were well characterized by using advanced spectroscopic techniques like IR, 1H NMR, 13C NMR and Mass spectra. The identification of these impurities will be productive for the quality control during the production and stability behavior of the regadenoson drug substance.

Characterization of stress degradation products of blonanserin by UPLC-QTOF-tandem mass spectrometry

RSC Advances ◽  
2015 ◽  
Vol 5 (85) ◽  
pp. 69273-69288 ◽  
Author(s):  
Pradipbhai D. Kalariya ◽  
Prinesh N. Patel ◽  
Mahesh Sharma ◽  
Prabha Garg ◽  
R. Srinivas ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Tandem Mass Spectrometry ◽  
Degradation Products ◽  
Structural Elucidation ◽  
Forced Degradation ◽  
Tandem Mass ◽  
Degradation Study ◽  
Stress Degradation

Forced degradation study of blonanserin and structural elucidation of its degradation products was performed using high resolution tandem mass spectrometry.

Characterization of the degradation products of bambuterol using LCMS-QTOF and NMR

2015 ◽  
Vol 7 (18) ◽  
pp. 7659-7673 ◽  
Author(s):  
A. Abiramasundari ◽  
V. Sudarsanam ◽  
Kamala K. Vasu
Keyword(s):  
Degradation Products ◽  
Forced Degradation ◽  
Degradation Study ◽  
Ich Guidelines ◽  
Mechanisms Of Formation

A systematic forced degradation study of bambuterol was carried out according to ICH guidelines. Twelve degradation products of bambuterol were identified and characterized. Plausible mechanisms of formation of the degradation products are discussed.

Characterization of the stress degradation products of tolvaptan by UPLC-Q-TOF-MS/MS

RSC Advances ◽  
2015 ◽  
Vol 5 (27) ◽  
pp. 21142-21152 ◽  
Author(s):  
Prinesh N. Patel ◽  
D. Rajesh Kumar ◽  
S. Gananadhamu ◽  
R. Srinivas
Keyword(s):  
Degradation Products ◽  
Forced Degradation ◽  
Dry Heat ◽  
Stress Degradation ◽  
Tof Ms

TVT was subjected to forced degradation under hydrolysis, oxidation, dry heat and photolysis conditions and the degradation products (DPs) formed have been characterized through UPLC-PDA and UPLC-Q-TOF-MS/MS studies.

Characterization of Forced Degradation Products & Related Substances of Bilastine by Online LC-Q-TOF-MS and In-silico Study of Characterized Compounds

2021 ◽  
Vol 11 (4) ◽  
pp. 563-579
Author(s):  
Amrej Singh Yadav ◽  
Aishwarya Prabha ◽  
Divya Dornala ◽  
Debasish Swain ◽  
Dilep Kumar Sigalapalli ◽  
...  
Keyword(s):  
In Silico ◽  
Degradation Products ◽  
Forced Degradation ◽  
Related Substances ◽  
In Silico Study ◽  
Tof Ms
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