Forced degradation study of thiocolchicoside: Characterization of its degradation products

2012 ◽  
Vol 61 ◽  
pp. 215-223 ◽  
Author(s):  
Del Grosso Erika ◽  
Aprile Silvio ◽  
Grosa Giorgio
Keyword(s):  
Degradation Products ◽  
Forced Degradation ◽  
Degradation Study

Synthesis and Characterization of Potential and Degraded Impurities of Regadenoson

2020 ◽  
Vol 16 (8) ◽  
pp. 1130-1139
Author(s):  
Singaram Sathiyanarayanan ◽  
Chidambaram Subramanian Venkatesan ◽  
Senthamaraikannan Kabilan
Keyword(s):  
Mass Spectra ◽  
Degradation Products ◽  
Hplc Method ◽  
Forced Degradation ◽  
Spectroscopic Techniques ◽  
A2a Adenosine Receptor ◽  
Degradation Study ◽  
Related Substances ◽  
Adenosine Receptor Agonist

Background: Regadenoson is an A2A adenosine receptor agonist that is a coronary vasodilator and commonly used as a pharmacologic cardiac stressing agents. Methods: HPLC method was used for the analysis of related substances. The degraded impurities during the process were isolated and characterized by IR, Mass and NMR spectral analysis. Results: Forced degradation study of regadenoson under conditions of hydrolysis (neutral, acidic and alkaline) and oxidations suggested in the ICH Q1A(R2) was accomplished. The drug showed significant degradation under all the above conditions. On the whole, five novel degradation products were found under diverse conditions along with process related impurities which were not reported earlier. Conclusion: All the degradation products were well characterized by using advanced spectroscopic techniques like IR, 1H NMR, 13C NMR and Mass spectra. The identification of these impurities will be productive for the quality control during the production and stability behavior of the regadenoson drug substance.

Characterization of stress degradation products of blonanserin by UPLC-QTOF-tandem mass spectrometry

RSC Advances ◽  
2015 ◽  
Vol 5 (85) ◽  
pp. 69273-69288 ◽  
Author(s):  
Pradipbhai D. Kalariya ◽  
Prinesh N. Patel ◽  
Mahesh Sharma ◽  
Prabha Garg ◽  
R. Srinivas ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
High Resolution ◽  
Tandem Mass Spectrometry ◽  
Degradation Products ◽  
Structural Elucidation ◽  
Forced Degradation ◽  
Tandem Mass ◽  
Degradation Study ◽  
Stress Degradation

Forced degradation study of blonanserin and structural elucidation of its degradation products was performed using high resolution tandem mass spectrometry.

Characterization of the degradation products of bambuterol using LCMS-QTOF and NMR

2015 ◽  
Vol 7 (18) ◽  
pp. 7659-7673 ◽  
Author(s):  
A. Abiramasundari ◽  
V. Sudarsanam ◽  
Kamala K. Vasu
Keyword(s):  
Degradation Products ◽  
Forced Degradation ◽  
Degradation Study ◽  
Ich Guidelines ◽  
Mechanisms Of Formation

A systematic forced degradation study of bambuterol was carried out according to ICH guidelines. Twelve degradation products of bambuterol were identified and characterized. Plausible mechanisms of formation of the degradation products are discussed.

scholarly journals FORCED DEGRADATION STUDY OF TORASEMIDE: CHARACTERIZATION OF ITS DEGRADATION PRODUCTS

2013 ◽  
Vol 36 (15) ◽  
pp. 2082-2094 ◽  
Author(s):  
Zarko Jovic ◽  
Ljiljana Zivanovic ◽  
Ana Protic ◽  
Marina Radisic ◽  
Mila Lausevic ◽  
...  
Keyword(s):  
Degradation Products ◽  
Forced Degradation ◽  
Degradation Study

LC-MS/MS method for the characterization of the forced degradation products of Entecavir

2014 ◽  
Vol 37 (4) ◽  
pp. 368-375 ◽  
Author(s):  
Thippani Ramesh ◽  
Pothuraju Nageswara Rao ◽  
Ramisetti Nageswara Rao
Keyword(s):  
Degradation Products ◽  
Forced Degradation

Identification and structural characterization of the stress degradation products of omeprazole using Q-TOF-LC-ESI-MS/MS and NMR experiments: evaluation of the toxicity of the degradation products

2019 ◽  
Vol 43 (19) ◽  
pp. 7294-7306 ◽  
Author(s):  
G. Shankar ◽  
Roshan M. Borkar ◽  
Suresh Udutha ◽  
M. Kanakaraju ◽  
G. Sai Charan ◽  
...  
Keyword(s):  
Gastroesophageal Reflux Disease ◽  
Proton Pump Inhibitor ◽  
Gastroesophageal Reflux ◽  
Degradation Products ◽  
Forced Degradation ◽  
Peptic Ulcers ◽  
Ich Guidelines ◽  
Stress Degradation ◽  
Forced Degradation Studies

Omeprazole (OMP), a prototype proton pump inhibitor used for the treatment of peptic ulcers and gastroesophageal reflux disease (GERD), was subjected to forced degradation studies as per ICH guidelines Q1A (R2).

Sign in / Sign up

Export Citation Format

Share Document