Role of the GNAS1 T393C polymorphism in patients with glioblastoma multiforme

2011 ◽  
Vol 18 (11) ◽  
pp. 1495-1499 ◽  
Author(s):  
N. El Hindy ◽  
N. Lambertz ◽  
H.S. Bachmann ◽  
U.H. Frey ◽  
M. Adamzik ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Gnas1 T393c

Deciphering the signaling pathways of cancer stem cells of glioblastoma multiforme: Role of Akt/mTOR and MAPK pathways

2011 ◽  
Vol 51 (1) ◽  
pp. 164-170 ◽  
Author(s):  
Meena Jhanwar-Uniyal ◽  
Ladislau Albert ◽  
Elise McKenna ◽  
Michael Karsy ◽  
Priya Rajdev ◽  
...  
Keyword(s):  
Stem Cells ◽  
Glioblastoma Multiforme ◽  
Cancer Stem Cells ◽  
Signaling Pathways ◽  
Mapk Pathways

scholarly journals Combining experiments and in silico modeling to infer the role of adhesion and proliferation on the collective dynamics of cells

2021 ◽  
Author(s):  
Hygor P. M. Melo ◽  
F. Raquel Maia ◽  
André S. Nunes ◽  
Rui L. Reis ◽  
Joaquim M. Oliveira ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Cell Adhesion ◽  
Glioblastoma Multiforme ◽  
In Silico ◽  
Relative Importance ◽  
Collective Dynamics ◽  
Surfaces And Interfaces ◽  
In Silico Modeling ◽  
Cell Cell

ABSTRACTThe collective dynamics of cells on surfaces and interfaces poses technological and theoretical challenges in the study of morphogenesis, tissue engineering, and cancer. Different mechanisms are at play, including, cell-cell adhesion, cell motility, and proliferation. However, the relative importance of each one is elusive. Here, experiments with a culture of glioblastoma multiforme cells on a substrate are combined with in silico modeling to infer the rate of each mechanism. By parametrizing these rates, the time-dependence of the spatial correlation observed experimentally is reproduced. The obtained results suggest a reduction in cell-cell adhesion with the density of cells. The reason for such reduction and possible implications for the collective dynamics of cancer cells are discussed.

scholarly journals Minocycline in Treating Glioblastoma Multiforme: Far beyond a Conventional Antibiotic

2020 ◽  
Vol 2020 ◽  
pp. 1-11
Author(s):  
Amir R. Afshari ◽  
Hamid Mollazadeh ◽  
Amirhossein Sahebkar
Keyword(s):  
Antimicrobial Activity ◽  
Glioblastoma Multiforme ◽  
Cancer Therapy ◽  
Cell Invasion ◽  
Treatment Approach ◽  
Tumor Cell Invasion ◽  
Surgical Interventions ◽  
Anticancer Effects ◽  
New Treatment

One of the most lethal forms of CNS pathologies is glioblastoma multiforme (GBM) that represents high invasiveness, uncontrolled proliferation, and angiogenic features. Its invasiveness is responsible for the high recurrence even after maximal surgical interventions. Minocycline is a semisynthetic analog of tetracyclines with potential anti-inflammatory and anticancer effects, distinct from its antimicrobial activity. In this review, we highlight the importance and the cytotoxic mechanisms of minocycline on GBM pathophysiology. Considering the role of certain enzymes in autophagy, apoptosis, tumor cell invasion, and metastatic ability, the possible use of tetracyclines for cancer therapy should be investigated, especially GBM. The present study is, therefore, going to cover the main topics in minocycline pharmacology to date, encouraging its consideration as a new treatment approach for cancer and GBM.

The Role of Kinase Signaling in Resistance to Bevacizumab Therapy for Glioblastoma Multiforme

2019 ◽  
Vol 34 (6) ◽  
pp. 345-354 ◽  
Author(s):  
Sara Ramezani ◽  
Nasim Vousooghi ◽  
Mohammad Taghi Joghataei ◽  
Shahrokh Yousefzadeh Chabok
Keyword(s):  
Glioblastoma Multiforme ◽  
Kinase Signaling

scholarly journals Supratentorial Glioblastoma Multiforme: The Role of Surgical Resection Versus Biopsy Among Older Patients

2010 ◽  
Vol 18 (1) ◽  
pp. 239-245 ◽  
Author(s):  
Kaisorn L. Chaichana ◽  
Tomas Garzon-Muvdi ◽  
Scott Parker ◽  
Jon D. Weingart ◽  
Alessandro Olivi ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Surgical Resection ◽  
Older Patients

scholarly journals Assessing Response UsingTc99m-MIBI Early after Interstitial Chemotherapy with Carmustine-Loaded Polymers in Glioblastoma Multiforme: Preliminary Results

2014 ◽  
Vol 2014 ◽  
pp. 1-6
Author(s):  
D. Cecchin ◽  
I. Schiorlin ◽  
A. Della Puppa ◽  
G. Lombardi ◽  
P. Zucchetta ◽  
...  
Keyword(s):  
Glioblastoma Multiforme ◽  
Single Photon ◽  
Statistical Significance ◽  
Photon Emission ◽  
Single Photon Emission ◽  
Volume Of Interest ◽  
Effect Of Treatment ◽  
The Difference ◽  
Photon Emission Tomography

Introduction. Early signs of response after applying wafers of carmustine-loaded polymers (gliadel) are difficult to assess with imaging because of time-related imaging changes.Tc99m-sestamibi (MIBI) brain single-photon emission tomography (SPET) has reportedly been used to reveal areas of cellularity distinguishing recurrent neoplasm from radionecrosis. Our aim was to explore the role of MIBI SPET in assessing response soon after gliadel application in glioblastoma multiforme (GBM).Methods. We retrospectively reviewed the charts on 28 consecutive patients with a radiological diagnosis of GBM who underwent MIBI SPET/CT before surgery (with intracavitary gliadel placement in 17 patients), soon after surgery, and at 4 months. The area of uptake was selected using a volume of interest that was then mirrored contralaterally to obtain a semiquantitative ratio.Results. After adjusting for ratio at the baseline, the effect of treatment (gliadel versus non-gliadel) was not statistically significant. Soon after surgery, however, 100% of patients treated with gliadel had a decreased ratio, as opposed to 62.5% of patients in the non-gliadel groupP=0.0316. The difference between ratios of patients with radical versus partial resection reached statistical significance by a small marginP=0.0528.Conclusions. These data seem to suggest that the MIBI ratio could be a valuable tool for monitoring the effect of gliadel early after surgery.

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