scholarly journals Immature porcine knee cartilage lesions show good healing with or without autologous chondrocyte transplantation

2006 ◽  
Vol 14 (10) ◽  
pp. 1066-1074 ◽  
Author(s):  
A.I. Vasara ◽  
M.M. Hyttinen ◽  
O. Pulliainen ◽  
M.J. Lammi ◽  
J.S. Jurvelin ◽  
...  
Keyword(s):  
Autologous Chondrocyte Transplantation ◽  
Chondrocyte Transplantation ◽  
Knee Cartilage ◽  
Cartilage Lesions ◽  
Good Healing ◽  
Porcine Knee ◽  
Autologous Chondrocyte

scholarly journals Mosaicplasty versus Matrix-Assisted Autologous Chondrocyte Transplantation for Knee Cartilage Defects: A Long-Term Clinical and Imaging Evaluation

2020 ◽  
Vol 10 (13) ◽  
pp. 4615
Author(s):  
Stefano Zaffagnini ◽  
Angelo Boffa ◽  
Luca Andriolo ◽  
Davide Reale ◽  
Maurizio Busacca ◽  
...  
Keyword(s):  
Activity Level ◽  
Autologous Chondrocyte Transplantation ◽  
Cartilage Defects ◽  
Chondrocyte Transplantation ◽  
Knee Cartilage ◽  
Cartilage Lesions ◽  
Long Term Follow Up ◽  
Autologous Chondrocyte

Different surgical procedures have been proposed over the past few years to treat cartilage lesions. The aim of this study was to compare mosaicplasty and matrix-assisted autologous chondrocyte transplantation (MACT) at long-term follow-up. Forty-three patients were included: 20 mosaicplasty and 23 MACT. Patients were evaluated before and 12 years after surgery with the International Knee Documentation Committee (IKDC) subjective and objective scores for symptoms and function, and with the Tegner score for activity level. Magnetic Resonance Imaging (MRI) was used to evaluate repair tissue with the MOCART 2.0 score. Mosaicplasty and MACT showed good clinical and MRI results (IKDC subjective score 75.3 ± 21.8 and 81.8 ± 13.0, both p < 0.0005). Mosaicplasty presented a 10% reoperation rate and a 25% overall failure rate, while no failures were documented in MACT (p = 0.016). While size did not influence the results in the MACT group, mosaicplasty presented lower IKDC objective and Tegner scores in lesions bigger than 2 cm2 (p = 0.031 and p = 0.014, respectively). Mosaicplasty and MACT presented both satisfactory clinical and MRI results at long-term follow-up. However, for larger lesions, MACT presented better subjective and objective outcomes, as well as less failures, which should be considered when choosing the most suitable treatment for patients affected by knee cartilage lesions.

Functional Outcome of Knee Articular Cartilage Repair in Adolescent Athletes

2005 ◽  
Vol 33 (8) ◽  
pp. 1147-1153 ◽  
Author(s):  
Kai Mithöfer ◽  
Tom Minas ◽  
Lars Peterson ◽  
Howard Yeon ◽  
Lyle J. Micheli
Keyword(s):  
Articular Cartilage ◽  
Functional Outcome ◽  
Cartilage Repair ◽  
Autologous Chondrocyte Transplantation ◽  
Full Thickness ◽  
Chondrocyte Transplantation ◽  
Adolescent Athletes ◽  
Cartilage Lesions ◽  
Articular Cartilage Lesions ◽  
Autologous Chondrocyte

Background Limited information exists about the treatment of full-thickness articular cartilage lesions of the knee in adolescent athletes. Purpose To evaluate the functional outcome and athletic activity after articular cartilage repair in the knees of adolescent athletes. Study Design Case series; Level of evidence, 4. Methods Twenty adolescent athletes with full-thickness articular cartilage lesions of the knee were treated with autologous chondrocyte transplantation. Functional outcome was evaluated by subjective patient outcome rating, knee activity scores, and level of athletic participation. Results At a mean of 47 months after autologous chondrocyte transplantation, 96% of adolescents reported good or excellent results with significant increases in postoperative Tegner activity scores and Lysholm scores. Ninety-six percent returned to high-impact sports and 60% to an athletic level equal or higher than that before knee injury. Return to preinjury sports correlated with shorter preoperative symptoms and a lower number of prior operations. All adolescents with preoperative symptoms ≤12 months returned to preinjury-level athletics, compared to 33% with preoperative intervals longer than 12 months. Conclusion Treatment of full-thickness articular injuries of the knee in adolescent athletes with autologous chondrocyte transplantation yields a high rate of functional success at a mean follow-up of 47 months. The rate of return to demanding athletic activities is higher in cases in which the preoperative duration of symptoms is 12 months or less.

Treatment of “Patellofemoral” Cartilage Lesions With Matrix-Assisted Autologous Chondrocyte Transplantation

2013 ◽  
Vol 42 (3) ◽  
pp. 626-634 ◽  
Author(s):  
Giuseppe Filardo ◽  
Elizaveta Kon ◽  
Luca Andriolo ◽  
Alessandro Di Martino ◽  
Stefano Zaffagnini ◽  
...  
Keyword(s):  
Autologous Chondrocyte Transplantation ◽  
Chondrocyte Transplantation ◽  
Cartilage Lesions ◽  
Autologous Chondrocyte

scholarly journals Early Efficacy of Type I Collagen-Based Matrix-Assisted Autologous Chondrocyte Transplantation for the Treatment of Articular Cartilage Lesions

2021 ◽  
Vol 9 ◽  
Author(s):  
Xiang Li ◽  
Shiao Li ◽  
Jiatian Qian ◽  
Yancheng Chen ◽  
Yiqin Zhou ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Type I Collagen ◽  
Hyaline Cartilage ◽  
T2 Mapping ◽  
Autologous Chondrocyte Transplantation ◽  
Histological Evaluation ◽  
Type I ◽  
Chondrocyte Transplantation ◽  
Cartilage Lesions ◽  
Autologous Chondrocyte

Background: Articular cartilage is a complex structure that allows for low frictional gliding and effective shock absorption. Various sports injuries and inflammatory conditions can lead to lesions in the articular cartilage, which has limited regenerative potential. Type I collagen combined with autologous chondrocytes in a three-dimensional culture were used to induce the regeneration of single-layer autologous expanded chondrocytes without chondrogenic differentiation.Purpose: To assess the clinical, radiological, and histological changes following collagen-based autologous chondrocyte transplantation (MACT) for chondral knee lesions.Methods: The study prospectively enrolled 20 patients with symptomatic knee chondral lesions (mean size lesion was 2.41 ± 0.43 cm2, range: 2.0–3.4 cm2) in the lateral femoral condyle and femoral groove who underwent type I collagen-based MACT between July 2017 and July 2019. knee injury and osteoarthritis outcome score (KOOS) was assessed before the procedure, and periodic clinical follow-up was conducted every 3 months for a maximum of 12 months following the procedure and at 1-year intervals thereafter. Magnetic resonance imaging (MRI) T2 mapping of repaired cartilage was also used for the quantitative analysis of regeneration. In one patient, second-look arthroscopy was performed to assess cartilage regeneration characteristics, and a portion of regenerated cartilage was harvested for histological evaluation 12 months after implantation.Results: At pre-operation and at three, six, 12, and 24 months after the operation, KOOS pain, symptoms, daily life activities, sports and recreation, as well as the quality of life were significantly improved between every two time points. Hematoxylin and eosin (HE) staining indicated that the newly formed cartilage was comprised of naive chondrocytes. Safranin O-fast (S-O) green staining of the regenerated tissue revealed fibroblast-like cells surrounded by glycosaminoglycans. Immunohistochemistry (IHC) analysis indicated that collagen type II was uniformly distributed at the deep zone of articular cartilage and type I collagen mainly depositing in the superficial cartilage layer. The T2 values for repaired tissue gradually decreased, eventually approaching near-average values.Conclusion: The present study demonstrated that type I collagen-based MACT is a clinically effective treatment for improving functionality and pain levels. Histological evidence confirmed hyaline cartilage induction and showed that repaired cartilage tended to emerge from the deep to the superficial layer. The quantitative MRI T2 mapping test indicated that there still was a difference between the transplanted cartilage and the surrounding hyaline cartilage. Taken together, the current method represents an efficient approach for the restoration of knee cartilage lesions.

scholarly journals Early Efficacy of Type I Collagen Based Matrix-Assisted Autologous Chondrocyte Transplantation to Treat Articular Cartilage Lesions

2021 ◽  
Author(s):  
Xiang Li ◽  
Jiatian Qian ◽  
Shiao Li ◽  
Peiliang Fu ◽  
Chengyan Chen
Keyword(s):  
Type I Collagen ◽  
Collagen Type ◽  
T2 Mapping ◽  
Autologous Chondrocyte Transplantation ◽  
Type I ◽  
Chondrocyte Transplantation ◽  
Cartilage Lesions ◽  
Autologous Chondrocyte

Abstract Purpose: To investigate the clinical, radiological, and histological results of type I collagen-based matrix-assisted autologous chondrocyte transplantation (MACT) in the treatment of chondral lesions of the knee.Methods: The study prospectively enrolled 20 patients with symptomatic knee chondral defects (mean size defect was 2.41±0.43 cm2, range 2.0 to 3.4 cm2) in the lateral femoral condyle and femoral groove who underwent type I collagen-based MACT between July 2017 and July 2019. KOOS was assessed preoperatively, with periodic clinical follow-up performed preoperatively and then every 3 months for up to 12 months postoperative period, and thereafter at 1-year intervals. During this follow-up, serial magnetic resonance imaging T2 mapping of repair cartilage was used to reflect the quantitative analysis quality of the regenerative cartilage. In one patient, second-look arthroscopy was performed at 12 months after implantation to assess the characteristics of cartilage regeneration.Results: Compared with preoperation, the score of the pain, symptoms, activities of daily living, sports and recreation, and quality of life showed statistically significant improvement with a significant difference at 3, 6, 12, and 24 months after operation(P<0.05). The difference in KOOS subscales scores between every two-time point was statistically significant (P<0.001). HE stains showed the newly formed cartilage was naive chondrocytes. Safranin O-fast green stain manifested in the regenerated tissue comprising predominantly fibroblast-like cells surrounded by glycosaminoglycans. Immunohistochemistry analysis showed that the expression of collagen type II was more clearly and evenly distributed than collagen type I.Conclusion: Type I collagen-based MACT was a clinically effective treatment for functional and pain level improvement, and this method presented histologic evidence of inducing hyaline‐like cartilage in cartilage lesions by biopsy in one case. The quantitative MRI T2-mapping test showed that there was a difference between the transplanted cartilage and the surrounding hyaline cartilage.

Diffusion-weighted imaging for the follow-up of patients after matrix-associated autologous chondrocyte transplantation

2010 ◽  
Vol 73 (3) ◽  
pp. 622-628 ◽  
Author(s):  
Klaus M. Friedrich ◽  
Tallal C. Mamisch ◽  
Christina Plank ◽  
Georg Langs ◽  
Stefan Marlovits ◽  
...  
Keyword(s):  
Diffusion Weighted Imaging ◽  
Autologous Chondrocyte Transplantation ◽  
Chondrocyte Transplantation ◽  
Diffusion Weighted ◽  
Autologous Chondrocyte
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