An improved liquid chromatographic method with electrochemical detection for direct determination of serotonin in microdialysates from Caudate-putamen and pineal gland regions of rat brain

2006 ◽  
Vol 155 (1) ◽  
pp. 143-148 ◽  
Author(s):  
P. Chandrani Gunaratna ◽  
Karen K. Cadle ◽  
Candice B. Kissinger
Keyword(s):  
Pineal Gland ◽  
Rat Brain ◽  
Electrochemical Detection ◽  
Chromatographic Method ◽  
Direct Determination ◽  
Caudate Putamen ◽  
Liquid Chromatographic Method ◽  
Liquid Chromatographic

Liquid-chromatographic method for determination of homovanillic acid in plasma, with electrochemical detection.

1987 ◽  
Vol 33 (1) ◽  
pp. 72-75 ◽  
Author(s):  
M Zumárraga ◽  
I Andia ◽  
B Bárcena ◽  
M I Zamalloa ◽  
R Dávilla
Keyword(s):  
Electrochemical Detection ◽  
Homovanillic Acid ◽  
Chromatographic Method ◽  
Detection Sensitivity ◽  
Simple Method ◽  
Liquid Chromatographic Method ◽  
Analytical Recovery ◽  
Standard Additions ◽  
Liquid Chromatographic

Abstract We describe a sensitive, simple method for measuring homovanillic acid in human plasma. The method is based on liquid chromatography with electrochemical detection. Sensitivity was 125 pg of homovanillic acid per injection. Samples were deproteinized and extracted with organic solvent before chromatography. Quantification was by the standard-additions technique. Analytical recovery of added HVA was 44.8 (SD 6.2%). We confirmed specificity by using serial amperometric detectors.

scholarly journals Determination of WR-1065 and WR-33278 by Liquid Chromatography with Electrochemical Detection: PVM 1:2002

2002 ◽  
Vol 85 (3) ◽  
pp. 551-554
Author(s):  
James A Pendergrass ◽  
Venkataraman Srinivasan ◽  
K Sree Kumar ◽  
William E Jackson ◽  
Thomas M Seed ◽  
...  
Keyword(s):  
Electrochemical Detection ◽  
Chromatographic Method ◽  
Measurement Precision ◽  
Assay Method ◽  
Liquid Chromatographic Method ◽  
External Standard ◽  
Precision And Accuracy ◽  
Liquid Chromatographic ◽  
Symmetrical Disulfide

Abstract A liquid chromatographic method using electrochemical detection is presented for measuring the thiol WR-1065 [2-(3-aminopropylamino) ethanethiol] and its symmetrical disulfide WR-33278 [NH2(CH2)3NHCH2CH2S]2. WR-1065 is the active, radioprotective drug derived from the phosphorothioate pro-drug WR-2721 (amifostine). External standard curves for both compounds were linear over the range of 40-200 pmol injected (r2 = 0.999 and 0.996 for the thiol and disulfide, respectively). The detection and quantitation limits for WR-1065 were 9 and 18 pmol, respectively, whereas the corresponding values for WR-33278 were 30 and 59 pmol, respectively. Within- and between-day determinations of measurement precision and accuracy for both compounds validated the suitability of this assay method.

Liquid chromatographic method for the determination of sirolimus in blood using electrochemical detection

2009 ◽  
Vol 23 (3) ◽  
pp. 267-272 ◽  
Author(s):  
Nobuo Mochizuki ◽  
Etsuko Suka ◽  
Kunihiro Matsumoto ◽  
Osamu Akimoto ◽  
Keiko Ohno ◽  
...  
Keyword(s):  
Electrochemical Detection ◽  
Chromatographic Method ◽  
Liquid Chromatographic Method ◽  
Liquid Chromatographic
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