Structural Basis of C-terminal β-Amyloid Peptide Binding by the Antibody Ponezumab for the Treatment of Alzheimer's Disease

2012 ◽  
Vol 421 (4-5) ◽  
pp. 525-536 ◽  
Author(s):  
Sherry L. La Porte ◽  
Sangeetha Subbarao Bollini ◽  
Thomas A. Lanz ◽  
Yasmina N. Abdiche ◽  
Alexander S. Rusnak ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Peptide Binding ◽  
Amyloid Peptide ◽  
Structural Basis ◽  
Β Amyloid ◽  
Β Amyloid Peptide

Pentapeptide Amides Interfere with the Aggregation of β-Amyloid Peptide of Alzheimer's Disease

2002 ◽  
Vol 292 (4) ◽  
pp. 931-936 ◽  
Author(s):  
Csaba Hetényi ◽  
Zoltán Szabó ◽  
Éva Klement ◽  
Zsolt Datki ◽  
Tamás Körtvélyesi ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Peptide ◽  
Β Amyloid ◽  
Β Amyloid Peptide

scholarly journals Macroautophagy—a novel β-amyloid peptide-generating pathway activated in Alzheimer's disease

2005 ◽  
Vol 171 (1) ◽  
pp. 87-98 ◽  
Author(s):  
W. Haung Yu ◽  
Ana Maria Cuervo ◽  
Asok Kumar ◽  
Corrinne M. Peterhoff ◽  
Stephen D. Schmidt ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cell Survival ◽  
Mammalian Target Of Rapamycin ◽  
Amyloid Peptide ◽  
Survival Pathways ◽  
Secretase Activity ◽  
Amyloid Aβ ◽  
Β Amyloid ◽  
Β Amyloid Peptide

Macroautophagy, which is a lysosomal pathway for the turnover of organelles and long-lived proteins, is a key determinant of cell survival and longevity. In this study, we show that neuronal macroautophagy is induced early in Alzheimer's disease (AD) and before β-amyloid (Aβ) deposits extracellularly in the presenilin (PS) 1/Aβ precursor protein (APP) mouse model of β-amyloidosis. Subsequently, autophagosomes and late autophagic vacuoles (AVs) accumulate markedly in dystrophic dendrites, implying an impaired maturation of AVs to lysosomes. Immunolabeling identifies AVs in the brain as a major reservoir of intracellular Aβ. Purified AVs contain APP and β-cleaved APP and are highly enriched in PS1, nicastrin, and PS-dependent γ-secretase activity. Inducing or inhibiting macroautophagy in neuronal and nonneuronal cells by modulating mammalian target of rapamycin kinase elicits parallel changes in AV proliferation and Aβ production. Our results, therefore, link β-amyloidogenic and cell survival pathways through macroautophagy, which is activated and is abnormal in AD.

Strength training or green tea prevent memory deficits in a β-amyloid peptide-mediated Alzheimer's disease model

2021 ◽  
Vol 143 ◽  
pp. 111186
Author(s):  
Helen L. Schimidt ◽  
Guilherme S. Carrazoni ◽  
Alexandre Garcia ◽  
Ivan Izquierdo ◽  
Pâmela B. Mello-Carpes ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Strength Training ◽  
Green Tea ◽  
Disease Model ◽  
Memory Deficits ◽  
Amyloid Peptide ◽  
Β Amyloid ◽  
Β Amyloid Peptide

scholarly journals AIP-1 ameliorates β-amyloid peptide toxicity in a Caenorhabditis elegans Alzheimer's disease model

2009 ◽  
Vol 18 (15) ◽  
pp. 2739-2747 ◽  
Author(s):  
Wail M. Hassan ◽  
David A. Merin ◽  
Virginia Fonte ◽  
Christopher D. Link
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Caenorhabditis Elegans ◽  
Disease Model ◽  
Amyloid Peptide ◽  
Β Amyloid ◽  
Β Amyloid Peptide

β-Amyloid Peptide: the Cell Compartment Multi-faceted Interaction in Alzheimer’s Disease

2019 ◽  
Vol 37 (2) ◽  
pp. 250-263 ◽  
Author(s):  
Pasquale Picone ◽  
Domenico Nuzzo ◽  
Daniela Giacomazza ◽  
Marta Di Carlo
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Peptide ◽  
Cell Compartment ◽  
Β Amyloid ◽  
Β Amyloid Peptide

scholarly journals CSF level of β-amyloid peptide predicts mortality in Alzheimer’s disease

2019 ◽  
Vol 11 (1) ◽  
Author(s):  
Adla Boumenir ◽  
Emmanuel Cognat ◽  
Severine Sabia ◽  
Claire Hourregue ◽  
Matthieu Lilamand ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Peptide ◽  
Β Amyloid ◽  
Β Amyloid Peptide

scholarly journals Paper-Based Detection Device for Alzheimer’s Disease—Detecting β-amyloid Peptides (1–42) in Human Plasma

Diagnostics ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 272
Author(s):  
Wei-Hsuan Sung ◽  
Jung-Tung Hung ◽  
Yu-Jen Lu ◽  
Chao-Min Cheng
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Operating Time ◽  
Amyloid Peptide ◽  
Buffer System ◽  
Amyloid Peptides ◽  
Β Amyloid ◽  
Β Amyloid Peptide ◽  
Short Operating Time ◽  
Tremendous Impact

The diagnosis of Alzheimer’s disease (AD) is frequently missed or delayed in clinical practice. To remedy this situation, we developed a screening, paper-based (P-ELISA) platform to detect β-amyloid peptide 1–42 (Aβ42) and provide rapid results using a small volume, easily accessible plasma sample instead of cerebrospinal fluid. The protocol outlined herein only requires 3 μL of sample per well and a short operating time (i.e., only 90 min). The detection limit of Aβ42 is 63.04 pg/mL in a buffer system. This P-ELISA-based approach can be used for early, preclinical stage AD screening, including screening for amnestic mild cognitive impairment (MCI) due to AD. It may also be used for treatment and stage monitoring purposes. The implementation of this approach may provide tremendous impact for an afflicted population and may well prompt additional and expanded efforts in both academic and commercial communities.

scholarly journals Biomarker profiles of Alzheimer’s disease and dynamic of the association between cerebrospinal fluid levels of β-amyloid peptide and tau

PLoS ONE ◽  
2019 ◽  
Vol 14 (5) ◽  
pp. e0217026 ◽  
Author(s):  
Aysha S. Mohamed Lafirdeen ◽  
Emmanuel Cognat ◽  
Severine Sabia ◽  
Claire Hourregue ◽  
Matthieu Lilamand ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Cerebrospinal Fluid ◽  
Amyloid Peptide ◽  
Cerebrospinal Fluid Levels ◽  
Β Amyloid ◽  
Β Amyloid Peptide ◽  
Fluid Levels
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