scholarly journals Genotype and antiretroviral drug resistance of human immunodeficiency virus-1 in Jazan, Saudi Arabia

2019 ◽  
Vol 12 (1) ◽  
pp. 117
Author(s):  
E. Zaki
Keyword(s):  
Human Immunodeficiency Virus ◽  
Drug Resistance ◽  
Saudi Arabia ◽  
Antiretroviral Drug Resistance ◽  
Antiretroviral Drug ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus 1

scholarly journals Genotyping and antiretroviral drug resistance of human immunodeficiency Virus-1 in Jazan, Saudi Arabia

Medicine ◽  
2020 ◽  
Vol 99 (49) ◽  
pp. e23274
Author(s):  
Eitezaz A. Zaki ◽  
Mai M. El-Daly ◽  
Ahmed Abdulhaq ◽  
Tagreed L. Al-Subhi ◽  
Ahmed M. Hassan ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Drug Resistance ◽  
Saudi Arabia ◽  
Antiretroviral Drug Resistance ◽  
Antiretroviral Drug ◽  
Immunodeficiency Virus ◽  
Human Immunodeficiency Virus 1

scholarly journals Human immunodeficiency virus-1 subtypes and antiretroviral drug resistance profiles among drug-naïve Brazilian blood donors

Transfusion ◽  
2006 ◽  
Vol 47 (1) ◽  
pp. 97-102 ◽  
Author(s):  
José Antonio Sá-Ferreira ◽  
Patrícia Alvarez Brindeiro ◽  
Saada Chequer-Fernandez ◽  
Amilcar Tanuri ◽  
Mariza Gonçalves Morgado
Keyword(s):  
Human Immunodeficiency Virus ◽  
Drug Resistance ◽  
Blood Donors ◽  
Antiretroviral Drug Resistance ◽  
Antiretroviral Drug ◽  
Immunodeficiency Virus ◽  
Drug Naïve ◽  
Human Immunodeficiency Virus 1

scholarly journals Virologic Failure and Human Immunodeficiency Virus Drug Resistance in Rural Cameroon With Regard to the UNAIDS 90-90-90 Treatment Targets

2016 ◽  
Vol 3 (4) ◽  
Author(s):  
Charlotte Boullé ◽  
Emilande Guichet ◽  
Charles Kouanfack ◽  
Avelin Aghokeng ◽  
Benjamin Onambany ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Drug Resistance ◽  
Viral Load ◽  
Virologic Failure ◽  
Reverse Transcriptase Inhibitors ◽  
Treatment Targets ◽  
Antiretroviral Drug Resistance ◽  
Antiretroviral Drug ◽  
Immunodeficiency Virus ◽  
Rural Cameroon

Abstract Background In rural Africa, data on virologic effectiveness of antiretroviral treatment (ART) are not sufficient to assess the gap with the UNAIDS 90-90-90 treatment targets. We investigated the prevalences of unsuppressed viral load and antiretroviral drug resistance and the profile of genotypic resistance mutations among patients routinely treated in rural Cameroon. Methods A cross-sectional study was performed in 2013–2014 among patients ≥15 years and on first-line ART for ≥6 months in a district hospital. Patients were offered free access to human immunodeficiency virus viral load testing. Genotypic drug resistance testing was done when the viral load was >1000 copies/mL. Multivariate logistic regression models were used to assess the relationship of unsuppressed viral load or antiretroviral drug resistance with sociodemographic and medical characteristics. Results Of 407 patients (women 74.9%, median age 41.8 years, median time on ART 29.2 months), 96 (23.6%; 95% confidence interval [CI], 19.5–28.0) had unsuppressed viral load and 74 (18.2%; 95% CI, 14.6–22.3) had antiretroviral drug resistance. The prevalences of unsuppressed viral load and resistance increased with time on ART, from 12.0% and 8.0% in the 6- to 12-month group to 31.3% and 27.1% in the >72-month group, respectively. All 74 patients with antiretroviral drug resistance were resistant to nonnucleoside reverse-transcriptase inhibitors, and 57 of them were also resistant to nucleoside reverse-transcriptase inhibitors. Conclusions Our estimations were among the highest observed in the west and central African region. The proportion of patients with virologic failure should be divided at least by 2 to reach the UNAIDS 90-90-90 treatment targets.

scholarly journals Eight-day Inpatient Directly Observed Therapy for Antiretroviral Therapy (ART) Failure: A Tool For Preventing Unnecessary ART Changes and Optimizing Adherence Support

2019 ◽  
Vol 70 (6) ◽  
pp. 1222-1225 ◽  
Author(s):  
Nicole E Winchester ◽  
Frank Maldarelli ◽  
Yolanda Mejia ◽  
Nicola Dee ◽  
Robin Dewar ◽  
...  
Keyword(s):  
Human Immunodeficiency Virus ◽  
Drug Resistance ◽  
Antiretroviral Therapy ◽  
Virologic Failure ◽  
Directly Observed Therapy ◽  
Antiretroviral Drug Resistance ◽  
Antiretroviral Drug ◽  
Adherence Support ◽  
Immunodeficiency Virus

Abstract Eight-day inpatient directly observed therapy confirmed nonadherence as the major cause of virologic failure for 9 (45%) of 20 highly treatment-experienced persons with human immunodeficiency virus, extensive antiretroviral drug resistance, and high self-reported adherence rates, preventing unnecessary regimen changes.

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