scholarly journals Distinct mechanism of action for antitumoral neutral cyclometalated Pt(II)-complexes bearing antifungal imidazolyl-based drugs

2021 ◽  
pp. 111663
Author(s):  
Natalia Fernández-Pampín ◽  
Mónica Vaquero ◽  
Tania Gil ◽  
Gustavo Espino ◽  
Darío Fernández ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Distinct Mechanism

scholarly journals The Phosphoenolpyruvate:Sugar Phosphotransferase System Is Involved in Sensitivity to the Glucosylated Bacteriocin Sublancin

2015 ◽  
Vol 59 (11) ◽  
pp. 6844-6854 ◽  
Author(s):  
C. V. Garcia De Gonzalo ◽  
E. L. Denham ◽  
R. A. T. Mars ◽  
J. Stülke ◽  
W. A. van der Donk ◽  
...  
Keyword(s):  
Staphylococcus Aureus ◽  
Mechanism Of Action ◽  
Mode Of Action ◽  
Phosphotransferase System ◽  
Content Type ◽  
Gram Positive Bacteria ◽  
Distinct Mechanism ◽  
Genomic Studies ◽  
Increased Sensitivity ◽  
Bacterial Sensitivity

ABSTRACTThe mode of action of a group of glycosylated antimicrobial peptides known as glycocins remains to be elucidated. In the current study of one glycocin, sublancin, we identified the phosphoenolpyruvate:sugar phosphotransferase system (PTS) ofBacillusspecies as a key player in bacterial sensitivity. Sublancin kills several Gram-positive bacteria, such asBacillusspecies andStaphylococcus aureus, including methicillin-resistantS. aureus(MRSA). Unlike other classes of bacteriocins for which the PTS is involved in their mechanism of action, we show that the addition of PTS-requiring sugars leads to increased resistance rather than increased sensitivity, suggesting that sublancin has a distinct mechanism of action. Collectively, our present mutagenesis and genomic studies demonstrate that the histidine-containing phosphocarrier protein (HPr) and domain A of enzyme II (PtsG) in particular are critical determinants for bacterial sensitivity to sublancin.

scholarly journals Erratum: Corrigendum: Responding to the challenge of untreatable gonorrhea: ETX0914, a first-in-class agent with a distinct mechanism-of-action against bacterial Type II topoisomerases

2015 ◽  
Vol 5 (1) ◽  
Author(s):  
Gregory S. Basarab ◽  
Gunther H. Kern ◽  
John McNulty ◽  
John P. Mueller ◽  
Kenneth Lawrence ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Type Ii ◽  
Distinct Mechanism ◽  
Bacterial Type

scholarly journals A new anti-HER2 antibody that enhances the anti-tumor efficacy of trastuzumab and pertuzumab with a distinct mechanism of action

2020 ◽  
Vol 119 ◽  
pp. 48-58 ◽  
Author(s):  
Xuesai Zhang ◽  
Jianhe Chen ◽  
Zhibing Weng ◽  
Qingrou Li ◽  
Le Zhao ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Distinct Mechanism

Imipramine and fluoxetine prevent the stress-induced escape deficits in rats through a distinct mechanism of action

1995 ◽  
Vol 6 (1) ◽  
pp. 66???73 ◽  
Author(s):  
C. Gambarana ◽  
O. Ghiglieri ◽  
I. Taddei ◽  
A. Tagliamonte ◽  
M. G. De Montis
Keyword(s):  
Mechanism Of Action ◽  
Distinct Mechanism

scholarly journals P08.57 Distinct mechanism-of-action of dianhydrogalactitol (VAL-083) overcomes chemoresistance in glioblastoma

2017 ◽  
Vol 19 (suppl_3) ◽  
pp. iii66-iii66
Author(s):  
B. Zhai ◽  
A. Gobielewska ◽  
A. Steino ◽  
J. A. Bacha ◽  
D. M. Brown ◽  
...  
Keyword(s):  
Mechanism Of Action ◽  
Distinct Mechanism
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