Challenges associated with elucidating the mechanisms of the hypocholesterolaemic activity of saponins

2016 ◽  
Vol 23 ◽  
pp. 52-65 ◽  
Author(s):  
Dayun Zhao
Keyword(s):  
Hypocholesterolaemic Activity

Hypocholesterolaemic activity of a novel autochthonous potential probiotic Lactobacillus plantarum YS5 isolated from yogurt

LWT ◽  
2019 ◽  
Vol 111 ◽  
pp. 876-882 ◽  
Author(s):  
Yousef Nami ◽  
Reza Vaseghi Bakhshayesh ◽  
Mohammad Manafi ◽  
Mohammad Amin Hejazi
Keyword(s):  
Lactobacillus Plantarum ◽  
Probiotic Lactobacillus ◽  
Hypocholesterolaemic Activity

scholarly journals The isolation of 2,3-oxidosqualene from the liver of rats treated with 1-dodecylimidazole, a novel hypocholesterolaemic agent

1972 ◽  
Vol 130 (1) ◽  
pp. 153-157 ◽  
Author(s):  
Sandra D. Atkin ◽  
B. Morgan ◽  
K. H. Baggaley ◽  
J. Green
Keyword(s):  
Rat Liver ◽  
Mass Spectra ◽  
Cholesterol Biosynthesis ◽  
Anaerobic Conditions ◽  
Lower Serum ◽  
Unknown Compound ◽  
Lower Serum Cholesterol ◽  
Labelled Compound ◽  
Liver Homogenates ◽  
Hypocholesterolaemic Activity

1. Non-saponifiable lipid from the livers of rats treated with 1-dodecylimidazole contained an unidentified compound that was not present in the livers from untreated animals. 2. Treated rats had lower serum cholesterol concentrations than control rats. 3. 1-Dodecylimidazole, when added to rat liver slices, inhibited the incorporation of [1-14C]acetate and [2-14C]mevalonate into digitonin-precipitable sterols and resulted in the accumulation of a labelled compound, which was chromatographically identical with the unknown compound described in 1 above. 4. Rats treated with 1-dodecylimidazole incorporated less [14C]mevalonate into liver digitonin-precipitable sterols than untreated animals and accumulated the unknown compound as a labelled intermediate. 5. The unknown intermediate had the same chromatographic properties, n.m.r. and mass spectra as authentic 2,3-oxidosqualene. 6. The identity of the intermediate as 2,3-oxidosqualene was further established by showing that it was incorporated into sterols by rat liver homogenates under anaerobic conditions. In addition, incubation of [14C]squalene with rat liver homogenates resulted in trapping of the radioactivity by the added intermediate. 7. It is suggested that the hypocholesterolaemic activity of 1-dodecylimidazole results in part from the inhibition of cholesterol biosynthesis at the level of 2,3-oxidosqualene sterol cyclase.

Hypocholesterolaemic activity of 3-hydroxy-3-methyl-glutaryl flavanones enriched fraction from bergamot fruit (Citrus bergamia): “In vivo” studies

2014 ◽  
Vol 7 ◽  
pp. 558-568 ◽  
Author(s):  
Leonardo Di Donna ◽  
Domenico Iacopetta ◽  
Anna R. Cappello ◽  
Giselda Gallucci ◽  
Emanuela Martello ◽  
...  
Keyword(s):  
In Vivo Studies ◽  
Hypocholesterolaemic Activity ◽  
Citrus Bergamia

scholarly journals Hypocholesterolaemic Activity of Lupin Peptides: Investigation on the Crosstalk between Human Enterocytes and Hepatocytes Using a Co-Culture System Including Caco-2 and HepG2 Cells

Nutrients ◽  
2016 ◽  
Vol 8 (7) ◽  
pp. 437 ◽  
Author(s):  
Carmen Lammi ◽  
Chiara Zanoni ◽  
Simonetta Ferruzza ◽  
Giulia Ranaldi ◽  
Yula Sambuy ◽  
...  
Keyword(s):  
Hepg2 Cells ◽  
Culture System ◽  
Hypocholesterolaemic Activity
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