scholarly journals New phenolic compounds from Vitex negundo var. heterophylla and their antioxidant and NO inhibitory activities

2015 ◽  
Vol 19 ◽  
pp. 174-181 ◽  
Author(s):  
Ping Hu ◽  
Dahong Li ◽  
Kaibo Wang ◽  
Hao Wang ◽  
Zihou Wang ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Vitex Negundo ◽  
Inhibitory Activities

scholarly journals Bioprocessing of common pulses changed seed microstructures, and improved dipeptidyl peptidase-IV and α-glucosidase inhibitory activities

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Elisa Di Stefano ◽  
Apollinaire Tsopmo ◽  
Teresa Oliviero ◽  
Vincenzo Fogliano ◽  
Chibuike C. Udenigwe
Keyword(s):  
Phenolic Compounds ◽  
Protein Digestibility ◽  
Dipeptidyl Peptidase ◽  
Dipeptidyl Peptidase Iv ◽  
Dpp Iv ◽  
Glucosidase Inhibitors ◽  
Yellow Peas ◽  
Faba Beans ◽  
Inhibitory Activities ◽  
Green Lentils

Abstract Type 2 diabetes mellitus (T2DM) is a leading cause of death globally. T2DM patients experience glucose intolerance, and inhibitors of dipeptidyl peptidase IV (DPP-IV) and α-glucosidase are used as drugs for T2DM management. DPP-IV and α-glucosidase inhibitors are also naturally contained in foods, but their potency can be affected by the food matrix and processing methods. In this study, germination and solid-state fermentation (SSF) were used to alter pulse seed microstructures, to convert compounds into more bioactive forms, and to improve their bioaccessibility. Germination substantially modified the seed microstructure, protein digestibility, contents and profiles of phenolic compounds in all the pulses. It also increased DPP-IV and α-glucosidase inhibitory activities in chickpeas, faba beans and yellow peas. Compared to germination, SSF with Lactobacillus plantarum changed the content and the profile of phenolic compounds mainly in yellow peas and green lentils because of greater disruption of the seed cell wall. In the same pulses, heat treatment and SSF of flour increased DPP-IV and α-glucosidase inhibitory activities. The results of this study suggest that germination and SSF with L. plantarum are effective and simple methods for modulating phenolic and protein profiles of common pulses and improve the action on DPP-IV and α-glucosidase.

scholarly journals Bio-guided isolation of new phenolic compounds from Hippocrepis emerus flowers and investigation of their antioxidant, tyrosinase and elastase inhibitory activities

2020 ◽  
Vol 35 ◽  
pp. 28-36 ◽  
Author(s):  
Marie Schmitt ◽  
Abdulmagid Alabdul Magid ◽  
Jane Hubert ◽  
Nicolas Etique ◽  
Laurent Duca ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Inhibitory Activities

scholarly journals α-Amylase and α-Glucosidase Inhibitory Activities of Phenolic Extracts from Eucalyptus grandis × E. urophylla Bark

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Ping Jiang ◽  
Jia Xiong ◽  
Fei Wang ◽  
Mary H. Grace ◽  
Mary Ann Lila ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Ellagic Acid ◽  
Enzyme Activities ◽  
Total Phenolics ◽  
Ethyl Acetate Extract ◽  
Eucalyptus Grandis ◽  
Significant Inhibition ◽  
Active Fraction ◽  
Inhibitory Effects ◽  
Inhibitory Activities

This study evaluated the inhibitory effects of different extracts and fractions from Eucalyptus. grandis × urophylla bark (EB) against α-glucosidase and α-amylase enzyme activities. The ethyl acetate extract (EB-E) showed the highest activity among others. Seven fractions were derived from EB-E; among them EB-E-7 showed the highest significant inhibition of both enzymes, with IC50 of 1.40±0.18 and 1.72±0.12 μg/mL, respectively. EB-E and its active fraction EB-E-7 showed highest contents of total phenolics: 178.79±4.68 and 920.4±5.46 mg GAEag−1, respectively. HPLC-MS analysis of EB-E-7 revealed the presence of ellagic acid, quercetin-glucuronide, quercetin-3-α-rhamnopyranoside, and ellagic acid rhamnoside as major compounds, together with smaller concentrations of myricetin-rhamnoside, isorhamnetin-hexoside, myricetin-3-α-arabinofuranoside, and isorhamnetin. Therefore, the phenolic compounds from Eucalyptus grandis × E. urograndis bark potently inhibited α-amylase and α-glucosidase activity, having potential in prevention of hyperglycemia.

scholarly journals α-Glucosidase and pancreatic lipase inhibitory activities and glucose uptake stimulatory effect of phenolic compounds from Dendrobium formosum

2017 ◽  
Vol 27 (4) ◽  
pp. 480-487 ◽  
Author(s):  
Prachyaporn Inthongkaew ◽  
Nutputsorn Chatsumpun ◽  
Chonlakan Supasuteekul ◽  
Tharita Kitisripanya ◽  
Waraporn Putalun ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Glucose Uptake ◽  
Pancreatic Lipase ◽  
Inhibitory Activities

scholarly journals Phenolic Constituents from the Heartwood of Artocapus Altilis and their Tyrosinase Inhibitory Activity

2012 ◽  
Vol 7 (2) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Mai Ha Khoa Nguyen ◽  
Hai Xuan Nguyen ◽  
Mai Thanh Thi Nguyen ◽  
Nhan Trung Nguyen
Keyword(s):  
Phenolic Compounds ◽  
Vanillic Acid ◽  
Inhibitory Activity ◽  
Kojic Acid ◽  
Positive Control ◽  
Coumaric Acid ◽  
Meoh Extract ◽  
Tyrosinase Inhibitory Activity ◽  
Phenolic Constituents ◽  
Inhibitory Activities

From the MeOH extract of the heartwood of Artocapus altilis, thirteen phenolic compounds have been isolated, namely curcumin (1), desmethoxycurcumin (2), retrodihydrochalcone (3), apigenin (4), tangeretin (5), nobiletin (6), O-methyldehydrodieugenol (7), dehydrodieugenol (8), β-hydroxypropiovanillone (9), p-coumaric acid (10), p-hydroxybenzaldehyde (11), vanillin (12), and vanillic acid (13). This is the first report on the presence of these compounds in the heartwood of A. altilis. Compounds 1, 2, and 10 showed more potent tyrosinase inhibitory activities, with IC50 values ranging from 2.3 to 42.0 μM, than the positive control kojic acid (IC50, 44.6 μM). The most active compound, p-coumaric acid (10) (IC50, 2.3 μM), was 22 times more active in tyrosinase inhibitory activity than kojic acid.

Differential α-amylase/α-glucosidase inhibitory activities of plant-derived phenolic compounds: a virtual screening perspective for the treatment of obesity and diabetes

2017 ◽  
Vol 8 (5) ◽  
pp. 1942-1954 ◽  
Author(s):  
Hassan Rasouli ◽  
Seyed Mohammad-Bagher Hosseini-Ghazvini ◽  
Hadi Adibi ◽  
Reza Khodarahmi
Keyword(s):  
Molecular Docking ◽  
Phenolic Compounds ◽  
Virtual Screening ◽  
Inhibitory Activity ◽  
Obesity And Diabetes ◽  
Inhibitory Activities ◽  
Treatment Of Obesity

The present study aims to evaluate the α-amylase and α-glucosidase inhibitory activity of 26 polyphenols using molecular docking and virtual screening studies.

Antioxidant Flavonols and Phenolic Compounds from Atraphaxis frutescens and Their Inhibitory Activities against Insect Phenoloxidase and Mushroom Tyrosinase

2016 ◽  
Vol 79 (12) ◽  
pp. 3065-3071 ◽  
Author(s):  
Batsukh Odonbayar ◽  
Toshihiro Murata ◽  
Javzan Batkhuu ◽  
Kosho Yasunaga ◽  
Rina Goto ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Mushroom Tyrosinase ◽  
Inhibitory Activities
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