Characterization of In Vitro Synthesized Equine Metabolites of the Selective Androgen Receptor Modulators S24 and S4

2012 ◽  
Vol 32 (9) ◽  
pp. 562-568 ◽  
Author(s):  
Oliver Krug ◽  
Andreas Thomas ◽  
Simon Beuck ◽  
Ina Schenk ◽  
Marc Machnik ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

Characterization of equine urinary metabolites of selective androgen receptor modulators (SARMs) S1, S4 and S22 for doping control purposes

2015 ◽  
Vol 7 (8) ◽  
pp. 673-683 ◽  
Author(s):  
Annelie Hansson ◽  
Heather Knych ◽  
Scott Stanley ◽  
Mario Thevis ◽  
Ulf Bondesson ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Urinary Metabolites ◽  
Doping Control ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

Development of an Analytical Methodology for the Qualitative and Quantitative Characterization of Capsules with Andarine, in Order to Use them to Investigate the Pharmacotoxicological Profile of the Substance

2019 ◽  
Vol 70 (8) ◽  
pp. 2759-2763
Author(s):  
Amalia Miklos ◽  
Amelia Tero Vescan ◽  
Lenard Farczadi ◽  
Silvia Imre ◽  
Camil Eugen Vari ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
The Internet ◽  
Mass Content ◽  
European Pharmacopoeia ◽  
Quantitative Characterization ◽  
Analytical Methodology ◽  
Qualitative And Quantitative ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

Andarine is one of the most commonly used doping substance between selective androgen receptor modulators (SARMs). The purpose of our study is to characterize qualitatively and quantitatively andarine capsules purchased legally via the Internet through a rapid and precise UHPLC method and the uniformity of mass, content and dissolution assays were determined following the methodology of the European Pharmacopoeia 8th Ed. Regarding the uniformity of mass, the capsules are within the permissible limits, but regarding the active substance content, an average of 4.99 mg of andarine/capsule was obtained (with an RSD of 5.41%) from the 25 mg/capsule declared by the manufacturer.

In vitro metabolic studies of novel selective androgen receptor modulators and their use for doping control analysis

2021 ◽  
Author(s):  
Katarzyna Kowalczyk ◽  
Julio César Torres‐Elguera ◽  
Anna Jarek ◽  
Anna Konopka ◽  
Dorota Kwiatkowska ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Doping Control ◽  
Control Analysis ◽  
Metabolic Studies ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

Synthesis, Structure−Activity Relationships, and Characterization of Novel Nonsteroidal and Selective Androgen Receptor Modulators

2009 ◽  
Vol 52 (22) ◽  
pp. 7186-7191 ◽  
Author(s):  
Nathalie Schlienger ◽  
Birgitte W. Lund ◽  
Jan Pawlas ◽  
Fabrizio Badalassi ◽  
Fabio Bertozzi ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

scholarly journals Design, Synthesis, and Biological Characterization of Metabolically Stable Selective Androgen Receptor Modulators

2004 ◽  
Vol 47 (4) ◽  
pp. 993-998 ◽  
Author(s):  
Craig A. Marhefka ◽  
Wenqing Gao ◽  
Kiwon Chung ◽  
Juhyun Kim ◽  
Yali He ◽  
...  
Keyword(s):  
Androgen Receptor ◽  
Biological Characterization ◽  
Design Synthesis ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

scholarly journals Synthesis of Aryl Propionamide Scaffold Containing a Pentafluorosulfanyl Moiety as SARMs

Molecules ◽  
2019 ◽  
Vol 24 (23) ◽  
pp. 4227
Author(s):  
Shao ◽  
Zhou ◽  
Yang ◽  
Wang ◽  
Lu ◽  
...  
Keyword(s):  
Clinical Trial ◽  
Androgen Receptor ◽  
Medicinal Chemistry ◽  
Selective Androgen Receptor Modulators ◽  
Receptor Modulators

The pentafluorosulfane (SF5) group, as a more electronegative bioisostere than the trifluoromethyl (CF3) group, has been gaining greater attention and increasingly reported usage in medicinal chemistry. Ostarine is the selective androgen receptor modulators (SARMs) containing a CF3 group in clinical trial III. In this study, 21 ostarine derivatives for replacing the CF3 group with SF5 substituents were synthesized. Some SF5-derivatives showed androgen receptor (AR) agonistic activities in vitro. The results pointed to the potential of using this scaffold to develop new AR agonists.

scholarly journals Novel Protective Group Synthesis of Androgen Receptor Modulators with Steroidal and Nonsteroidal Scaffolds

2019 ◽  
Author(s):  
Matthias Grill ◽  
Melanie Patt ◽  
Alex Odermatt
Keyword(s):  
Androgen Receptor ◽  
Molecular Mechanisms ◽  
Anabolic Androgenic Steroids ◽  
Protective Group ◽  
Mood Changes ◽  
Selective Androgen Receptor Modulators ◽  
And Performance ◽  
Androgenic Steroids ◽  
Receptor Modulators

Anabolic androgenic steroids (AAS) are frequently used either clinically, by athletes, or for body shaping due to their muscle building and performance enhancing properties. AAS misuse is associated with cardiovascular diseases, mood changes and endocrine issues. Despite the recognition of the severe adverse effects of AAS misuse, the underlying molecular mechanisms are insufficiently understood. Selective androgen receptor modulators (SARMs) are supposed to diminish the adverse androgenic AAS effects while maximizing anabolic effects. In order to obtain androgen receptor modulating compounds of high purity for mechanistic in vitro investigations, this study summarizes protocols of optimized chemical synthesis for five AAS and two SARMs.

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