Anticancer efficacy of the ethyl acetate extract from the traditional Chinese medicine herb Celastrus orbiculatus against human gastric cancer

2017 ◽  
Vol 205 ◽  
pp. 147-157 ◽  
Author(s):  
Haibo Wang ◽  
Lide Tao ◽  
Tengyang Ni ◽  
Hao Gu ◽  
Feng Jin ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Ethyl Acetate ◽  
Ethyl Acetate Extract ◽  
Human Gastric Cancer ◽  
Celastrus Orbiculatus ◽  
Anticancer Efficacy

scholarly journals Ethyl acetate extract of Elephantopus mollis Kunth induces apoptosis in human gastric cancer cells

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Tran Dang Thanh Tam ◽  
Truong Thi Bich Ngoc ◽  
Nguyen Thi Hoai Nga ◽  
Nguyen Thi My Trinh ◽  
Tran Linh Thuoc ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Ethyl Acetate ◽  
Caspase 3 ◽  
Ethyl Acetate Extract ◽  
Human Fibroblasts ◽  
Gastric Cancer Cell Line ◽  
Perennial Herb ◽  
Human Gastric Cancer ◽  
Potential Candidate ◽  
Ags Cells

Abstract Background Gastric cancer is one of the most leading causes of cancer death worldwide. Therefore, treatment studies have been being conducted, one of which is screening of novel agents from medicinal herbs. Elephantopus mollis Kunth (EM) belonging to Asteraceae family is a perennial herb with several therapeutic properties including anticancer activity. However, the effect of this species on gastric cancer has not been reported yet. In this study, cytotoxicity of different EM crude extracts was investigated on AGS gastric cancer cell line. Besides, the effects of extract on nuclear morphology, caspase-3 activation, and gene expression were also explored. Results The results showed that ethyl acetate extract exhibited a remarkably inhibitory ability (IC50 = 27.5 μg/ml) on the growth of AGS cells, while causing less toxicity to normal human fibroblasts. The extract also induced apoptotic deaths in AGS cells as evidenced by cell shrinkage, formation of apoptotic bodies, nuclear fragmentation, caspase-3 activation, and the upregulation of BAK and APAF-1 pro-apoptotic genes related to mitochondrial signaling pathway. Specifically, BAK and APAF-1 mRNA expression levels showed 2.57 and 2.71-fold increases respectively. Conclusions The current study not only proved the anti-gastric cancer activity of EM ethyl acetate extract but also proposed its molecular mechanism. The extract could be a potential candidate for further investigation.

Acaricidal activities of traditional Chinese medicine against the house dust mite, Dermatophagoides farinae

Parasitology ◽  
2010 ◽  
Vol 137 (6) ◽  
pp. 975-983 ◽  
Author(s):  
HAI-QIANG WU ◽  
JING LI ◽  
ZHEN-DAN HE ◽  
ZHI-GANG LIU
Keyword(s):  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Ethyl Acetate ◽  
Petroleum Ether ◽  
House Dust ◽  
House Dust Mite ◽  
Petroleum Ether Extract ◽  
House Dust Mites ◽  
Dermatophagoides Farinae ◽  
Dust Mite

SUMMARYObjective. This paper assessed the potential of traditional Chinese medicine (TCM) preparations for using as environmentally acceptable and alternative commercial acaricides. Methods. 22 kinds of TCM, which contained abundant essential oils and showed insecticidal effects, were collected. Samples extracted with petroleum ether, ethyl acetate and methanol were tested against house dust mites Dermatophagoides farinae and their toxicity assessed. Results. The results showed that 3 TCM of Cinnamonum cassia, Eugenia caryophyllata and Pogostemon cablin have higher activity, and the parallel tests showed that the petroleum ether extract had higher activities (0·0046 mg/cm2, 0·005 mg/cm2 and 0·006 mg/cm2 respectively, 24 h, LD50) than the extracts of ethyl acetate and methanol. The acaricidal activity of the ethyl acetate extracts from C. cassia, P. cablin and Asarum sieboldii (0·00144 mg/cm2, 0·00347 mg/cm2 and 0·05521 mg/cm2 respectively, 24 h, LD50) were almost comparable to that of benzyl benzoate and dibutyl phthalate. However, the methanolic extracts of were less effective. Conclusions. This study shows the use of extracts with petroleum ether of C. cassia, P. cablin and E. caryophyllata as eco-friendly biodegradable agents for the control of the house dust mite.

scholarly journals Tubeimoside-1 Inhibits Glioblastoma Growth, Migration, and Invasion via Inducing Ubiquitylation of MET

Cells ◽  
2019 ◽  
Vol 8 (8) ◽  
pp. 774 ◽  
Author(s):  
Jiangjun Cao ◽  
Erhu Zhao ◽  
Qingzong Zhu ◽  
Juanli Ji ◽  
Zekun Wei ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Chinese Medicine ◽  
Cell Growth ◽  
Traditional Chinese Medicine ◽  
Receptor Tyrosine Kinase ◽  
Protein Level ◽  
Migration And Invasion ◽  
Anti Cancer ◽  
Inhibit Cell Growth ◽  
Receptor Tyrosine Kinase Family

Tubeimoside-1 (TBMS1) is one of the extracts of rhizoma bolbostemmae, which has remarkable anti-cancer function in the treatment of esophagus and gastric cancer in traditional Chinese medicine. However the mechanisms of its anti-cancer function is remain unclear. In this study, we demonstrate that TBMS1 could inhibit cell growth and metastasis in glioblastoma. MET is a member of the receptor tyrosine kinase family, which amplifies frequently in various human cancers. As an important proto-oncogene, multiple inhibitors have been developed for the therapy of cancers. Here, we found TBMS1 could reduce/decrease the protein level of MET via increasing its Ubiquitination degradation. Therefore, TBMS1 is a promising compound for the treatment of glioblastoma and an inhibitor of MET.

scholarly journals Jianpi Bushen, a Traditional Chinese Medicine Therapy, Combined with Chemotherapy for Gastric Cancer Treatment: A Meta-Analysis of Randomized Controlled Trials

2018 ◽  
Vol 2018 ◽  
pp. 1-14 ◽  
Author(s):  
Yunbo Chen ◽  
Guijuan Zhang ◽  
Xiaoping Chen ◽  
Xuefeng Jiang ◽  
Fengjie Bie ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Cancer Treatment ◽  
Randomized Controlled Trials ◽  
Meta Analysis ◽  
Cochrane Library ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Gastric Cancer Treatment

Objective. To investigate the effects of Jianpi Bushen (JPBS), a traditional Chinese medicine that is used to invigorate the spleen and tonify the kidney, combined with chemotherapy for the treatment of gastric cancer. Methods. Literature retrieval was performed in PubMed, EMBASE, Cochrane Library, MEDLINE, CNKI, Wanfang Data Information Site, and VIP from inception to October 2017. Randomized controlled trials to evaluate the effects of JPBS combined with chemotherapy were identified. The primary reported outcomes were KPS (Karnofsky Performance Status), clinical curative efficiency, immune function, blood system, and nonhematologic system. Review Manager 5.3 (RevMan 5.3) was used for data analysis, and the quality of the studies was also appraised. Results. A total of 26 studies were included with 3098 individuals. The results of the meta-analysis indicated that treatment of gastric cancer with the combination of JPBS and chemotherapy resulted in better outcomes compared to chemotherapy alone. Conclusion. Evidence from the meta-analysis suggested that JPBS combined with chemotherapy has a positive effect on gastric cancer treatment. However, additional rigorously designed and large sample randomized controlled trials are required to confirm the efficacy and safety of this treatment.

scholarly journals Systems pharmacology to reveal multi-scale mechanisms of traditional Chinese medicine for gastric cancer

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Lulu Zhang ◽  
Yue Xiao ◽  
Ruijie Yang ◽  
Siyi Wang ◽  
ShuangXin Ma ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Chinese Medicine ◽  
Traditional Chinese Medicine ◽  
Prediction Models ◽  
Target Prediction ◽  
Treatment Method ◽  
Current Treatment ◽  
Systems Pharmacology ◽  
Multi Scale ◽  
Formidable Challenge

AbstractBecause of the complex etiology, the treatment of gastric cancer is a formidable challenge for contemporary medical. The current treatment method focuses on traditional surgical procedures, supplemented by other treatments. Among these other treatments, Traditional Chinese Medicine (TCM) plays an important role. Here, we used the systems pharmacology approach to reveal the potential molecular mechanism of PRGRC on gastric cancer which composes of Pinellia ternata(Thunb.) Breit., Rheum palmatumL., Gentiana scabraBunge, Radix Aucklandiae and Citrus aurantium L. This approach combines pharmacokinetics analysis with pharmacodynamics evaluation for the active compounds screening, targets prediction and pathways assessing. Firstly, through pharmacokinetic evaluation and target prediction models, 83 potential compounds and 184 gastric cancer-related targets were screened out. Then, the results of network analysis suggested that the targets of PRGRC were mainly involved two aspects: apoptosis and inflammation. Finally, we verified the reliability of the above analysis at the cellular level by using naringenin and luteolin with good pharmacokinetic activity as representative compounds. Overall, we found that PRGRC could influence the development of gastric cancer from a multi-scale perspective. This study provided a new direction for analyzing the mechanism of TCM.

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