Pharmacokinetic comparative study of gastrodin after oral administration of Gastrodia elata Bl. extract and its compatibility with the different indigents of Ligusticum chuanxiong Hort. to rats

2016 ◽  
Vol 191 ◽  
pp. 82-86 ◽  
Author(s):  
Peng-yi Hu ◽  
Peng.-fei Yue ◽  
Qin Zheng ◽  
Ming Yang ◽  
Guo-song Zhang ◽  
...  
Keyword(s):  
Oral Administration ◽  
Comparative Study ◽  
Gastrodia Elata ◽  
Ligusticum Chuanxiong

scholarly journals Pharmacokinetic Comparative Study of Gastrodin and Rhynchophylline after Oral Administration of Different Prescriptions ofYizhiTablets in Rats by an HPLC-ESI/MS Method

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Zhaohui Ge ◽  
Yuanyuan Xie ◽  
Qionglin Liang ◽  
Yiming Wang ◽  
Guoan Luo
Keyword(s):  
Oral Administration ◽  
Comparative Study ◽  
Rat Plasma ◽  
Pharmacokinetic Parameters ◽  
Gastrodia Elata ◽  
Time Points ◽  
Esi Ms ◽  
Hydroxybenzyl Alcohol ◽  
Predetermined Time

Pharmacokinetic characters of rhynchophylline (RIN), gastrodin (GAS), and gastrodigenin (p-hydroxybenzyl alcohol, HBA) were investigated after oral administration of different prescriptions ofYizhi:Yizhitablets or effective parts oftianma(total saponins from Gastrodiae, EPT) andgouteng(rhynchophylla alkaloids, EPG). At different predetermined time points after administration, the concentrations of GAS, HBA, and RIN in rat plasma were determined by an HPLC-ESI/MS method, and the main pharmacokinetic parameters were investigated. The results showed that the pharmacokinetic parametersCmaxandCmax⁡andAUC0–∞(P<0.05) were dramatically different after oral administration of different prescriptions ofYizhi. The data indicated that the pharmacokinetic processes of GAS, HBA, and RIN in rats would interact with each other or be affected by other components inYizhi. The rationality of the compatibility ofUncariaandGastrodia elataas a classic “herb pair” has been verified from the pharmacokinetic viewpoint.

‌‌‌‌A comparative study of a commercial syrup and oral administration of injectable midazolam in pediatric dental sedation

2014 ◽  
Vol 10 (1) ◽  
pp. 17-28
Author(s):  
Katayon Salem ◽  
Shaghayegh Kamranzadeh ◽  
Shahnaz Shaeghi ◽  
Fatemeh Abdollah Gorji
Keyword(s):  
Oral Administration ◽  
Comparative Study

Comparative study of toxicological assessment of yttrium oxide nano- and microparticles in Wistar rats after 28 days of repeated oral administration

Mutagenesis ◽  
2019 ◽  
Vol 34 (2) ◽  
pp. 181-201 ◽  
Author(s):  
Archana Panyala ◽  
Srinivas Chinde ◽  
Srinivas Indu Kumari ◽  
Mohammad Fazlur Rahman ◽  
Mohammed Mahboob ◽  
...  
Keyword(s):  
Oral Administration ◽  
Comparative Study ◽  
Yttrium Oxide ◽  
Wistar Rats ◽  
Toxicological Assessment

scholarly journals Comparative study of oral mifepristone and endocervical prostaglandin-E2 gel as pre-induction cervical ripening agents in parturition

2020 ◽  
Vol 9 (9) ◽  
pp. 3825
Author(s):  
Prabhkiran Dhillon ◽  
Manash Biswas ◽  
Priyanka Tripathi ◽  
Vinod G. Nair
Keyword(s):  
Oral Administration ◽  
Comparative Study ◽  
Prostaglandin E2 ◽  
Caesarean Delivery ◽  
Cervical Ripening ◽  
P Value ◽  
Term Pregnancy ◽  
Exclusion Criteria ◽  
Pg E2 ◽  
Vertex Presentation

Background: Intracervical instillation of prostaglandin E2 is a well-known and widely practiced method of pre-induction cervical ripening. Mifepristone, due to its anti-progesterone action has been found to be a potential cervical ripening agent. This study was conducted to compare the safety, efficacy and outcome of these two drugs in pre-induction cervical ripening.Methods: One hundred antenatal women were recruited for the study; 50 in mifepristone arm and 50 in PG-E2 gel arm. Any singleton term pregnancy in vertex presentation with intact membranes and bishop’s score of <4 was included in the study. Any contraindication for vaginal delivery and any contraindication for mifepristone or PG-E2 were considered as exclusion criteria. Participants in the mifepristone arm were given tablet mifepristone 200 mg orally and those in PG-E2 gel group received endocervical instillation of PGE2 gel 0.5 mg, two doses 6 hours apart (if necessary). Induction of labour was considered successful if the parturient delivered within 48 hours of administration of mifepristone or first dose of PG-E2 gel, with or without labour augmentation with oxytocin. Delivery after 48 hours and caesarean delivery were considered unsuccessful induction.Results: There was a significant improvement in bishop’s score in mifepristone group 5.0±1.55 as compared to PG-E2 gel group 3.64±2.14; p value 0.001.Conclusions: Oral administration of 200 mg mifepristone is a safe, effective and convenient alternative to intracervical instillation of prostaglandin-E2 gel for pre-induction cervical ripening.

Clinico comparative study of Vamana and Virechana Karma in the management of Shvitra w.s.r. to Vitiligo

2017 ◽  
Vol 2 (1) ◽  
Author(s):  
Hemang Raghavani ◽  
Kishor Satani ◽  
Kunjal Bhatt ◽  
Anup Thakar
Keyword(s):  
Oral Administration ◽  
Comparative Study ◽  
Skin Disease ◽  
Random Sampling ◽  
Sampling Method ◽  
Group A ◽  
Group B

Introduction: One of the baffling problems of mankind since time immemorial is the skin disease. Shvitra (Vitiligo) may become; a psychologically devastating disorder when it typically occurs in exposed areas. Aim: To evaluate and compare the efficacy of the Vamana and Virechana Karma in the management of the Shvitra (Vitiligo). Materials and Method: In this study total 92 patients of Shvitra were registered at Panchakarma dept. of I.P.G.T. and R.A. Hospital, Jamnagar. Patients were randomly divided in three groups by lottery random sampling method. In Group A - Vamana Karma and in Group B - Virechana Karma was given. After Shodhana in both Groups and in Group C Oral administration of Darvigomootra Ghanavati 6g/day with the Apamarghkshara Lepa for 8 weeks was given. Result: In VASI Score 2.16% and 4.61% relief was found in Group A and B respectively which was statistically highly significant. While in Group C 0.38% relief was found which were statistically insignificant. Conclusion: Any kind of Shodhana therapy either Vamana or Virechana play a key role in the management of Shvitra. For long far and sustainable effect of the therapy Shodhana should be performed priorly.

Sign in / Sign up

Export Citation Format

Share Document