Comparative study of toxicological assessment of yttrium oxide nano- and microparticles in Wistar rats after 28 days of repeated oral administration

Mutagenesis ◽  
2019 ◽  
Vol 34 (2) ◽  
pp. 181-201 ◽  
Author(s):  
Archana Panyala ◽  
Srinivas Chinde ◽  
Srinivas Indu Kumari ◽  
Mohammad Fazlur Rahman ◽  
Mohammed Mahboob ◽  
...  
Keyword(s):  
Oral Administration ◽  
Comparative Study ◽  
Yttrium Oxide ◽  
Wistar Rats ◽  
Toxicological Assessment

Toxicological Assessment of Aqueous and Methanol Leaves Extracts of Scoparia dulcis Linn (Plantaginaceae) in Wistar Rats

2019 ◽  
Vol 3 (3) ◽  
pp. 64-70 ◽  
Author(s):  
Rashydah Ahmed ◽  
◽  
Hadiza Nuhu ◽  
Hajara Ibrahim ◽  
Aliyu Nuhu ◽  
...  
Keyword(s):  
Wistar Rats ◽  
Toxicological Assessment ◽  
Scoparia Dulcis

Comparative study of Ho3+doped yttria (yttrium oxide), LuAG, and YAG as gain media for eye-safe resonantly pumped lasers

2010 ◽  
Author(s):  
Akil Word-Daniels ◽  
Alex Newburgh ◽  
Arockiasamy Michael ◽  
Larry Merkle ◽  
Mark Dubinskii
Keyword(s):  
Comparative Study ◽  
Yttrium Oxide ◽  
Gain Media

scholarly journals RESVERATROL INCLUSION COMPLEX WITH β-CYCLODEXTRIN (RCD): CHARACTERIZATION AND EVALUATION OF TOXICITY IN WISTAR RATS

2016 ◽  
Vol 9 (1) ◽  
pp. 27 ◽  
Author(s):  
V. S. K. Nishihira ◽  
N. J. Mezzomo ◽  
M. D. Baldissera ◽  
R. A. Vaucher ◽  
C. G. Pinto ◽  
...  
Keyword(s):  
Inclusion Complex ◽  
Oral Administration ◽  
Biochemical Parameters ◽  
Wistar Rats ◽  
Metabolic Diseases ◽  
Hematological Parameters ◽  
Density Lipoprotein ◽  
Blood Parameters ◽  
Control Group ◽  
Scanning Calorimetry

<p class="RSCB01ARTAbstract"><strong>Objective</strong>:<strong> </strong>The aim of this study was to characterise the resveratrol inclusion complex with β-cyclodextrin (RCD) and evaluate their toxicity in wistar rats.</p><p class="RSCB01ARTAbstract"><strong>Methods: </strong>The RCD were prepared in ultra-turrax. For characterization of the RCD were used: Fourier transform infra-red Spectroscopy, Nuclear Magnetic Resonance (NMR), Differential Scanning Calorimetry (DSC) and X-ray powder diffraction. The RCD and others 4 treatments were performed by the chronic oral administration in 35 rats during 60 ds. After the treatments they were euthanized and the serum blood were collected to analyzed some hemogram and biochemical parameters including aspartyl aminotransferase (AST); alanine aminotransferase (AST); phosphatase alkaline (ALP); total bilirubin (TB); direct bilirubin (DB); total protein (TP); total cholesterol (TC), triacylglycerol (TAG), very low-density lipoprotein (VLDL), high-density lipoprotein (HDL), calcium, iron and phosphate using fully automated biochemistry analyzer.</p><p class="RSCB01ARTAbstract"><strong>Results: </strong>The characterization results indicated a successful formation of the RCD. All hematological parameters analysed were within the normal values in all the groups. Furthermore, the hemogram and biochemical parameters were significantly (P&gt;0.05) similar to the control group.</p><p class="RSCB01ARTAbstract"><strong>Conclusion: </strong>The daily oral administration during 60 d of RCD are not harmful on blood parameters of Wistar rats. Thus, RCD can be used safely for treatment of some metabolic diseases.</p>

scholarly journals Effect of the oral administration of monosodium glutamate during pregnancy and breast-feeding in the offspring of pregnant Wistar rats

2010 ◽  
Vol 25 (1) ◽  
pp. 37-42 ◽  
Author(s):  
Vinicius von Diemen ◽  
Manoel Roberto Maciel Trindade
Keyword(s):  
Weight Gain ◽  
Oral Administration ◽  
Wistar Rats ◽  
Monosodium Glutamate ◽  
The Other ◽  
Control Group ◽  
Pregnant Rats ◽  
Dependent Relation ◽  
Dose Dependent

PURPOSE: Determine the effects of the MSG (monosodium glutamate) in the offspring of pregnant rats through the comparison of the weight, NAL (nasal-anal length) and IL (Index of Lee) at birth and with 21 days of life. METHODS: Pregnant Wistar rats and their offspring were divided into 3 groups: GC, G10 and G20. Each of the groups received 0%, 10% and 20% of MSG, respectively from coupling until the end of the weaning period. RESULTS: Neither weight nor NAL were different among the groups at birth. The group G20 at birth had an IL lower than the group GC (p<0,05) and with 21 days of life presented weight and NAL lower than the groups G10 and this lower than the GC (p<0,01). Otherwise the G20 at 21 days of life had the IL similar to the other two groups. The weight profit percentage from birth to the 21st day of life was lower in the G20 regarding the other two groups (p<0,01). The G20 had a NAL increase percentage from birth to the 21st day of life lower than the G10 and this lower than the GC (p<0,01). CONCLUSIONS: MSG presented a dose-dependent relation in the variables weight and NAL. It caused a decrease in the growth pattern as well as in the weight gain pattern until the 21st day of life. The IL of the group 20% had an increased in relation to the control group after 3 weeks of follow up.

scholarly journals Subchronic toxcity study of Khaya senegalensis aqueous extract in rats

2021 ◽  
Vol 41 (1) ◽  
pp. 235-243
Author(s):  
K. T. Biobaku ◽  
A. A. Yusuf ◽  
F. M. Mshelbwala ◽  
E. S. Ajibola ◽  
B. S Okediran ◽  
...  
Keyword(s):  
Blood Cell ◽  
Oral Administration ◽  
Aqueous Extract ◽  
Wistar Rats ◽  
Histopathological Examination ◽  
Haemoglobin Concentration ◽  
Glucose Levels ◽  
Khaya Senegalensis ◽  
High Doses ◽  
Group B

This study was carried out to investigate the sub chronic effects of oral administration of different doses: 100mg/kg, 400mg/kg, l600mg/kg, 6400mg/kg of aqueous extract of Khaya senegalensis in wistar rats. The rats were randomly separated to groups "A-G". The group "A" was considered as a non treated control. The other groups B, C, D and E respectively, were test groups and were treated with the extract. The biochemical and haematological parameters were assessed after 21 days of oral administration of the extract. The liver, kidney, pancreas, and heart of various experimental rats were harvested and preserved. The parenchymal tissues were fixed and using a microtome prepared to slides. Histopathological changes were observed using standard methods. There were no significant differences in white blood cell (WBC), Differential leucocytes count (DLC), haemoglobin concentration, packed cell volume (PCV) and Red Blood Cell count (RBC) respectively. There was however a significant (P<0.05) decrease in the serum Alanine amino transferase (ALT) in groups B, C and D and also a significant (p<0.05) decrease in AST levels in group B and E. The blood glucose levels also decreased significantly (P<0.05) in groups concentration in groups C, D, and E. Histopathological examination showed moderate degenerative changes and congestions in the livers and kidneys and pancreas in all treated groups. This gave an insiglht on the effects of oral administration of an aqueous extract of Khaya senegalensis on the haematological and biochemical parameters, with the related tissue pathology, in experimental wistar rats. Conclusion could be made that care should be taken in prolonged administration of high doses of aqueous extract of  Khaya senegalensis man and animals.

scholarly journals Evaluation of Efficacy of Cucumis melo in Gentamycin and CPD Induced Urolithiasis on Rats

2021 ◽  
Vol 11 (1-s) ◽  
pp. 113-116
Author(s):  
Dhaval M Patel ◽  
Advaita B Patel ◽  
Bhumi R Patel ◽  
Deepa R Patel ◽  
Nishith K Patel
Keyword(s):  
Oral Administration ◽  
Calcium Oxalate ◽  
Analysis Of Variance ◽  
Cucumis Melo ◽  
Wistar Rats ◽  
Renal Excretion ◽  
Methanolic Extract ◽  
Urinary Oxalate ◽  
Calcium Oxalate Urolithiasis ◽  
Oxalate Synthesis

Evaluation of the efficacy of methanolic extract of Cucumis melo in urolithiasis induced by gentamycin and calculi producing diet on Wistar rats. Gentamycin (40 mg/kg, subcutaneously) and calculi-producing diet (CPD) was fed to induce urolithiasis on Wistar rats. The effect of oral administration of methanolic extract of Cucumis melo seed on calcium oxalate urolithiasis has been studied and is compared with the effect of oral administration of Cystone as standard on Wistar rats. Gentamycin and CPD feeding resulted in hyperoxaluria and calcium oxalate deposition as well as increased renal excretion of calcium and oxalate. Supplementation with methanolic extract of Cucumis melo seed reduced the elevated urinary oxalate, showing a regulatory action on endogenous oxalate synthesis. The results indicate that the seed of Cucumis melo is endowed with antiurolithiatic activity. Keywords: C. melo, Hyperoxaluria, calcium oxalate deposition, cystone, hyperoxaluria, analysis of variance

‌‌‌‌A comparative study of a commercial syrup and oral administration of injectable midazolam in pediatric dental sedation

2014 ◽  
Vol 10 (1) ◽  
pp. 17-28
Author(s):  
Katayon Salem ◽  
Shaghayegh Kamranzadeh ◽  
Shahnaz Shaeghi ◽  
Fatemeh Abdollah Gorji
Keyword(s):  
Oral Administration ◽  
Comparative Study

Hormonal assays following oral administration of bonny light crude oil on male wistar rats

2013 ◽  
Vol 12 (2) ◽  
pp. 53
Author(s):  
VictorA Fischer ◽  
ChristieE Fischer ◽  
Mfon Akpaso ◽  
OladapoA Ashiru
Keyword(s):  
Oral Administration ◽  
Crude Oil ◽  
Wistar Rats ◽  
Light Crude Oil ◽  
Male Wistar Rats
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