The effect of Nigella sativa alone, and in combination with dexamethasone, on tracheal muscle responsiveness and lung inflammation in sulfur mustard exposed guinea pigs

2011 ◽  
Vol 137 (2) ◽  
pp. 1028-1034 ◽  
Author(s):  
Mohammad Hossein Boskabady ◽  
Nassim Vahedi ◽  
Sediqa Amery ◽  
Mohammad Reza Khakzad
Keyword(s):  
Guinea Pigs ◽  
Lung Inflammation ◽  
Sulfur Mustard ◽  
Nigella Sativa

The Protective Effect of α-Hederin, the Active Constituent of Nigella sativa , on Lung Inflammation and Blood Cytokines in Ovalbumin Sensitized Guinea Pigs

2015 ◽  
Vol 29 (11) ◽  
pp. 1761-1767 ◽  
Author(s):  
Rana Keyhanmanesh ◽  
Saeideh Saadat ◽  
Mostafa Mohammadi ◽  
Amir-Ali Shahbazfar ◽  
Maryam Fallahi
Keyword(s):  
Protective Effect ◽  
Guinea Pigs ◽  
Lung Inflammation ◽  
Nigella Sativa ◽  
Active Constituent ◽  
Blood Cytokines

The effect of vitamin E on lung pathology in sulfur mustard-exposed guinea pigs

2016 ◽  
Vol 32 (12) ◽  
pp. 1971-1977 ◽  
Author(s):  
Zahra Gholamnezhad ◽  
Mohammad Hossein Boskabady ◽  
Sediqa Amery ◽  
Nassim Vahedi ◽  
Abass Tabatabaei ◽  
...  
Keyword(s):  
Vitamin E ◽  
Guinea Pigs ◽  
Lung Inflammation ◽  
Sulfur Mustard ◽  
Pulmonary Complications ◽  
Control Group ◽  
Lung Pathology ◽  
Pathological Changes ◽  
Bronchial Stenosis ◽  
Pathological Evaluation

Pulmonary complications of exposure to sulfur mustard (SM) gas range from no effect or mild symptoms to severe bronchial stenosis. In the present study, the protective effect of vitamin E on the lung inflammation of SM-exposed guinea pigs was examined. Guinea pigs ( n = 5 for each group) were exposed to ethanol (control group), 40 mg/m3 inhaled SM (SME group), SME treated with vitamin E (SME + E), SME treated with dexamethasone (SME + D), and SME treated with both treatments (SME + E + D). Pathological evaluation of the lung was done 14 days postexposure. The epithelial desquamation of trachea and other pathologic changes in the lung of the SME group were significantly higher than those in the control group. Furthermore, the pathological changes of trachea and lung in the SME + E and SME + E + D groups were significantly improved compared with those of SME group. In addition, the pathological changes of trachea and lung of SME + E and SME + E + D animals were significantly less than those of SME + D group.

scholarly journals The Protective Effects ofNigella sativaand Its Constituents on Induced Neurotoxicity

2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Mohammad Reza Khazdair
Keyword(s):  
Lung Inflammation ◽  
Sulfur Mustard ◽  
Nigella Sativa ◽  
Therapeutic Effects ◽  
Protective Effects ◽  
Pharmacological Activities ◽  
Bioactive Component ◽  
The World ◽  
Therapeutic Properties ◽  
Comprehensive Study

Nigella sativa(N. sativa) is an annual plant and widely used as medicinal plant throughout the world. The seeds of the plant have been used traditionally in various disorders and as a spice to ranges of Persian foods.N. sativahas therapeutic effects on tracheal responsiveness (TR) and lung inflammation on induced toxicity by Sulfur mustard.N. sativahas been widely used in treatment of various nervous system disorders such as Alzheimer disease, epilepsy, and neurotoxicity. Most of the therapeutic properties of this plant are due to the presence of some phenolic compounds especially thymoquinone (TQ), which is major bioactive component of the essential oil. The present review is an effort to provide a comprehensive study of the literature on scientific researches of pharmacological activities of the seeds of this plant on induced neurotoxicity.

The effect of vitamin E on tracheal responsiveness and lung inflammation in sulfur mustard exposed guinea pigs

2011 ◽  
Vol 23 (3) ◽  
pp. 157-165 ◽  
Author(s):  
Mohammad Hossein Boskabady ◽  
Sediqa Amery ◽  
Nassim Vahedi ◽  
Mohammad Reza Khakzad
Keyword(s):  
Vitamin E ◽  
Guinea Pigs ◽  
Lung Inflammation ◽  
Sulfur Mustard

THE PROTECTIVE EFFECT OF NIGELLA SATIVA ON LUNG INJURY OF SULFUR MUSTARD–EXPOSED GUINEA PIGS

2008 ◽  
Vol 34 (4) ◽  
pp. 183-194 ◽  
Author(s):  
Boskabady Mohammad Hossein ◽  
Vahedi Nasim ◽  
Amery Sediqa
Keyword(s):  
Lung Injury ◽  
Protective Effect ◽  
Guinea Pigs ◽  
Sulfur Mustard ◽  
Nigella Sativa

scholarly journals The effect of Nigella sativa extract on tracheal responsiveness and lung inflammation in ovalbumin-sensitized guinea pigs

Clinics ◽  
2011 ◽  
Vol 66 (5) ◽  
pp. 879-887 ◽  
Author(s):  
Mohammad Hossein Boskabady ◽  
Rana Keyhanmanesh ◽  
Saeed Khamneh ◽  
Mohammad Ali Ebrahimi
Keyword(s):  
Guinea Pigs ◽  
Lung Inflammation ◽  
Nigella Sativa
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