Antimalarial activity of Lactucin and Lactucopicrin: sesquiterpene lactones isolated from Cichorium intybus L.

2004 ◽  
Vol 95 (2-3) ◽  
pp. 455-457 ◽  
Author(s):  
Theodore A. Bischoff ◽  
Charles J. Kelley ◽  
Yvette Karchesy ◽  
Maria Laurantos ◽  
Phuc Nguyen-Dinh ◽  
...  
Keyword(s):  
Antimalarial Activity ◽  
Sesquiterpene Lactones ◽  
Cichorium Intybus

scholarly journals Kasani beej (Cichorium intybus): Ayurvedic View, Folk View, Phytochemistry and Modern Therapeutic Uses

2021 ◽  
Vol 8 (2) ◽  
pp. 114-125
Author(s):  
Shailja Choudhary ◽  
Hemlata Kaurav ◽  
Gitika Chaudhary
Keyword(s):  
Medicinal Plant ◽  
Arid Regions ◽  
Sesquiterpene Lactones ◽  
Cichorium Intybus ◽  
Vegetable Crop ◽  
Therapeutic Uses ◽  
Traditional Remedy ◽  
Coffee Substitute ◽  
Phytochemical Constituents ◽  
Asteraceae Family

Cichorium intybus is commonly known as Chicory, kasani. It is a recognized medicinal plant that belongs to the Asteraceae family. This plant is a well-known traditional herb used in various medicinal systems like Ayurveda, Unani and Siddha medicinal system to treat variety of diseases ranging from wounds to diabetes. The species is native to the European region (Mediterranean region) but can also grow in the temperate and semi-arid regions. The juice extracted from this plant is used as a traditional remedy to cure uterus cancer and tumors. The plant is well-known for its roots that are used as an additive in coffee as it provides bitterness in taste without the caffeine. It is also reported that the roots of the plant contain 40% inulin and acts as an anti-diabetic agent. Historically, the plant was cultivated by ancient Egyptians as a medicinal plant, vegetable crop, coffee substitute and also used as animal forage. Cichorium intybus contains various phytochemical constituents mainly sesquiterpene lactones, caffeic acid derivatives, inulin flavonoids, alkaloids, phenols, steroids terpenoids and many more. The reported pharmacological properties of the C. intybus plant include hepatoprotective, anti-diabetic, anti-cancerous, anti-inflammatory, analgesic, cardiovascular, antioxidant, antimicrobial, anthelmintic, antimalarial, anti-allergic and gastroprotective activities. In this review article, the medicinal and ayurvedic importance of C. intybus plant along with its phytochemicals are briefly explained.

Sesquiterpene Lactones from Cichorium intybus

2011 ◽  
Vol 66 ◽  
pp. 0729 ◽  
Author(s):  
S. Shah ◽  
Z. Ali ◽  
A. Malik ◽  
I. A. Khan ◽  
S. Saied
Keyword(s):  
Sesquiterpene Lactones ◽  
Cichorium Intybus

scholarly journals Antimalarial Activity of Sesquiterpene Lactones from Vernonia cinerea

2006 ◽  
Vol 54 (10) ◽  
pp. 1437-1439 ◽  
Author(s):  
Aun Chea ◽  
Sotheara Hout ◽  
Christophe Long ◽  
Laurence Marcourt ◽  
Robert Faure ◽  
...  
Keyword(s):  
Antimalarial Activity ◽  
Sesquiterpene Lactones ◽  
Vernonia Cinerea

Antimalarial Activity of Sesquiterpene Lactones from Vernonia cinerea.

ChemInform ◽  
2007 ◽  
Vol 38 (14) ◽  
Author(s):  
Aun Chea ◽  
Sotheara Hout ◽  
Christophe Long ◽  
Laurence Marcourt ◽  
Robert Faure ◽  
...  
Keyword(s):  
Antimalarial Activity ◽  
Sesquiterpene Lactones ◽  
Vernonia Cinerea

scholarly journals Relationship between Levels of Sesquiterpene Lactones in Chicory and Sensory Evaluation

1998 ◽  
Vol 123 (2) ◽  
pp. 326-329 ◽  
Author(s):  
Angeline M. Peters ◽  
Aart van Amerongen
Keyword(s):  
Regression Analysis ◽  
Pilot Study ◽  
Linear Regression ◽  
Sensory Evaluation ◽  
Sesquiterpene Lactones ◽  
Linear Regression Analysis ◽  
Cichorium Intybus ◽  
Flavor Intensity ◽  
The Relationship

In this pilot study, we investigated the relationship between levels of bitter sesquiterpene lactones and sensory evaluation of chicory (Cichorium intybus L.). The levels of two bitter sesquiterpene lactones—lactucopicrin and lactucin-like sesquiterpene lactones—were measured by ELISA in raw and cooked chicory samples from several cultivars. Data were compared with the results of a sensory evaluation on the flavor attributes bitterness, typical chicory flavor, and total flavor intensity of identical chicory samples. Linear regression analysis demonstrated that the levels of lactucin-like sesquiterpene lactones were significantly related to bitterness (P = 0.006) and total flavor intensity (P = 0.03) attributes in raw chicory samples. When cooked chicory samples were evaluated, the levels of lactucin-like sesquiterpene lactones were significantly related to bitterness (P = 0.002), typical chicory flavor (P < 0.001), and total flavor intensity (P = 0.009) attributes, while lactucopicrin levels were related to bitterness (P = 0.002) only. These results show that the ELISA can be useful to predict flavor attributes in chicory.

KASNI (CICHORIUM INTYBUS L.): A REVIEW ON MEDICINAL UTILITY IN PERSPECTIVE OF UNANI MEDICINE

2020 ◽  
Vol 13 (2) ◽  
Author(s):  
Mohd Afsahul Kalam ◽  
Bazila Majeed ◽  
Aieman Yaqoob ◽  
Riehana Ghani ◽  
Shafiqur Rahman
Keyword(s):  
Chemical Constituents ◽  
Sesquiterpene Lactones ◽  
Hepatoprotective Activity ◽  
Cichorium Intybus ◽  
Perennial Herb ◽  
Internal Organs ◽  
Unani Medicine ◽  
Tartaric Acids ◽  
Therapeutic Uses ◽  
Bright Blue

Kasni (Cichorium intybus L.) or Chicory is a perennial herb of the dandelion family, (Asteraceae), usually with bright blue flowers, rarely white or pink which is used widely in Unani System of Medicine. It is an erect and procumbent herb that attains about 40-80cm hight. There are two main varieties of Kasni one issweet and second is wild. The most popular variety of Kasni used for medicinal purposes is Cichorium intybus L. Different parts of the herb are used for medicinal purposes like leaves, seeds and root. It is well known for the resolvent action of internal organs and especially for its hepatoprotective and nephroprotective properties, regarding the hepatoprotective activity, chicory extract reduces the levels of hepatic enzymes such as alanine aminotransferase, aspartate aminotransferase and alkaline phosphatase. It contains dietary fiber Inulin which is useful in treating diabetes and constipation. Besides inulin it contains other chemical constituents like sesquiterpene lactones, coumarins, citric and tartaric acids, lactic, acetic, palmitic, pyruvic acid etc. Its leaves contain vitamin B2 and C, root contains series of glucofructosans. The main actions which are attributed to chicory are deobstruent, diuretic, blood purifier, antipyretic and antiinflammatory as mentioned in Unani medicine. It is recommended in the treatment of jaundice, gastritis, ascites, arthritis, asthma and many other disorders, either alone or in compound form. This review gives knowledge on distribution, morphology, phytochemistry and pharmacological aspects along with its therapeutic uses in perspective of Unani System of Medicine.

scholarly journals Anti-protozoal activity of extracts from chicory (Cichorium intybus) against Cryptosporidium parvum in cell culture

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Ian David Woolsey ◽  
Angela H. Valente ◽  
Andrew R. Williams ◽  
Stig M. Thamsborg ◽  
Henrik T. Simonsen ◽  
...  
Keyword(s):  
Growth Inhibition ◽  
Cryptosporidium Parvum ◽  
Sesquiterpene Lactones ◽  
Treatment Options ◽  
Cell Monolayer ◽  
Cichorium Intybus ◽  
Water Soluble ◽  
Root Extracts ◽  
Free Media ◽  
Invasion Assays

AbstractCryptosporidium spp. are responsible for severe public health problems and livestock production losses. Treatment options are limited to only one drug available for human and bovine cryptosporidiosis, respectively, and both drugs exhibit only partial efficacy. Sesquiterpene lactones (SL) are plant bioactive compounds that function as a defence mechanism against herbivores. SL have demonstrated anti-parasitic properties against a range of parasitic taxa but knowledge about their anti-Cryptosporidium efficacy is limited. The effect of SL-rich leaf and root extracts from chicory (Cichorium intybus cv. Spadona) was investigated using human colon adenocarcinoma (HCT-8) cells infected with Cryptosporidium parvum. C. parvum oocysts were inoculated onto the cell monolayer and i) incubated for 4 hours with extracts (leaf and root extracts 300, 150, 75, 37.5, 18.75 and 9.375 μg/mL) in triplicates followed by incubation in bioactive free media (sporozoite invasion assays) or ii) incubated for 4 hours in bioactive free media followed by 48-hours incubation with extracts (growth inhibition assays). Extract toxicity on HCT-8 cells was assessed via water-soluble tetrazolium (WST)-1 assay prior to quantifying parasitic growth via immunofluorescence. Both extracts demonstrated dose-dependent inhibition in the growth inhibition assays (p = < 0.0001 for both extracts) but not in the invasion assays. Anti-parasitic activity did not appear to be solely related to SL content, with the extract with lower SL content (leaf) exhibiting higher inhibition at 300 μg/ml. However, given the limited treatment options available for Cryptosporidium spp., our study encourages further investigation into the use of chicory extracts to identify novel active compound(s) inhibiting these protozoa.

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