Dual CD44 and folate receptor-targeted nanoparticles for cancer diagnosis and anticancer drug delivery

2016 ◽  
Vol 236 ◽  
pp. 38-46 ◽  
Author(s):  
Jae-Young Lee ◽  
Ubonvan Termsarasab ◽  
Ju-Hwan Park ◽  
Song Yi Lee ◽  
Seung-Hak Ko ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Cancer Diagnosis ◽  
Folate Receptor ◽  
Targeted Nanoparticles ◽  
Anticancer Drug Delivery

Bifunctional supramolecular prodrug vesicles constructed from a camptothecin derivative with a water-soluble pillar[5]arene for cancer diagnosis and therapy

2019 ◽  
Vol 55 (73) ◽  
pp. 10892-10895 ◽  
Author(s):  
Guangping Sun ◽  
Zhimei He ◽  
Min Hao ◽  
Zuqiang Xu ◽  
Xiao-Yu Hu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Cancer Diagnosis ◽  
Water Soluble ◽  
Tumor Diagnosis ◽  
Anticancer Drug Delivery ◽  
Diagnosis And Therapy ◽  
Cancer Diagnosis And Therapy

Bifunctional supramolecular prodrug nanocarriers have been successfully constructed for efficient anticancer drug delivery and tumor diagnosis and therapy.

Dendrimer nanoarchitectures for cancer diagnosis and anticancer drug delivery

2017 ◽  
Vol 22 (2) ◽  
pp. 314-326 ◽  
Author(s):  
Ashok Kumar Sharma ◽  
Avinash Gothwal ◽  
Prashant Kesharwani ◽  
Hashem Alsaab ◽  
Arun K. Iyer ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Cancer Diagnosis ◽  
Anticancer Drug Delivery

scholarly journals Single- versus Dual-Targeted Nanoparticles with Folic Acid and Biotin for Anticancer Drug Delivery

Pharmaceutics ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 326
Author(s):  
Magdalena Jurczyk ◽  
Katarzyna Jelonek ◽  
Monika Musiał-Kulik ◽  
Artur Beberok ◽  
Dorota Wrześniok ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Cancer Therapy ◽  
Anticancer Drug ◽  
Human Cancer ◽  
Tumour Microenvironment ◽  
Passive Targeting ◽  
Targeted Nanoparticles ◽  
Anticancer Drug Delivery ◽  
Novel Approach

Cancer is one of the major causes of death worldwide and its treatment remains very challenging. The effectiveness of cancer therapy significantly depends upon tumour-specific delivery of the drug. Nanoparticle drug delivery systems have been developed to avoid the side effects of the conventional chemotherapy. However, according to the most recent recommendations, future nanomedicine should be focused mainly on active targeting of nanocarriers based on ligand-receptor recognition, which may show better efficacy than passive targeting in human cancer therapy. Nevertheless, the efficacy of single-ligand nanomedicines is still limited due to the complexity of the tumour microenvironment. Thus, the NPs are improved toward an additional functionality, e.g., pH-sensitivity (advanced single-targeted NPs). Moreover, dual-targeted nanoparticles which contain two different types of targeting agents on the same drug delivery system are developed. The advanced single-targeted NPs and dual-targeted nanocarriers present superior properties related to cell selectivity, cellular uptake and cytotoxicity toward cancer cells than conventional drug, non-targeted systems and single-targeted systems without additional functionality. Folic acid and biotin are used as targeting ligands for cancer chemotherapy, since they are available, inexpensive, nontoxic, nonimmunogenic and easy to modify. These ligands are used in both, single- and dual-targeted systems although the latter are still a novel approach. This review presents the recent achievements in the development of single- or dual-targeted nanoparticles for anticancer drug delivery.

HER2-Mediated Anticancer Drug Delivery: Strategies to Prepare Targeting Ligands Highly Specific for the Receptor

2015 ◽  
Vol 22 (21) ◽  
pp. 2525-2538 ◽  
Author(s):  
Enrica Calce ◽  
Luca Monfregola ◽  
Michele Saviano ◽  
Stefania De Luca
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Anticancer Drug Delivery ◽  
Delivery Strategies

Advances in Nanoparticles as Anticancer Drug Delivery Vector: Need of this Century

2020 ◽  
Vol 26 (15) ◽  
pp. 1637-1649 ◽  
Author(s):  
Imran Ali ◽  
Sofi D. Mukhtar ◽  
Heyam S. Ali ◽  
Marcus T. Scotti ◽  
Luciana Scotti
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Medical Science ◽  
Drug Carriers ◽  
Anticancer Drug Delivery ◽  
Ph Values ◽  
Delivery Vector ◽  
Future Challenges ◽  
Smart Drug ◽  
Smart Drug Delivery

Background: Nanotechnology has contributed a great deal to the field of medical science. Smart drugdelivery vectors, combined with stimuli-based characteristics, are becoming increasingly important. The use of external and internal stimulating factors can have enormous benefits and increase the targeting efficiency of nanotechnology platforms. The pH values of tumor vascular tissues are acidic in nature, allowing the improved targeting of anticancer drug payloads using drug-delivery vectors. Nanopolymers are smart drug-delivery vectors that have recently been developed and recommended for use by scientists because of their potential targeting capabilities, non-toxicity and biocompatibility, and make them ideal nanocarriers for personalized drug delivery. Method: The present review article provides an overview of current advances in the use of nanoparticles (NPs) as anticancer drug-delivery vectors. Results: This article reviews the molecular basis for the use of NPs in medicine, including personalized medicine, personalized therapy, emerging vistas in anticancer therapy, nanopolymer targeting, passive and active targeting transports, pH-responsive drug carriers, biological barriers, computer-aided drug design, future challenges and perspectives, biodegradability and safety. Conclusions: This article will benefit academia, researchers, clinicians, and government authorities by providing a basis for further research advancements.

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