scholarly journals Lung inflammation does not affect the clearance kinetics of lipid nanocapsules following pulmonary administration

2016 ◽  
Vol 235 ◽  
pp. 24-33 ◽  
Author(s):  
Aateka Patel ◽  
A. Woods ◽  
Yanira Riffo-Vasquez ◽  
Anna Babin-Morgan ◽  
Marie-Christine Jones ◽  
...  
Keyword(s):  
Lung Inflammation ◽  
Lipid Nanocapsules ◽  
Pulmonary Administration ◽  
Clearance Kinetics ◽  
Kinetics Of

Comparative Clearance Kinetics of Beat Damaged (Hdrc) and Antibody Coated Red Cells (Igrc)

1982 ◽  
Vol 62 (2) ◽  
pp. 7P-7P ◽  
Author(s):  
A.M. Peters ◽  
M. J. Walport ◽  
K. B. Elkon ◽  
P. P. Ferjencik ◽  
G. R. V. Hughes ◽  
...  
Keyword(s):  
Red Cells ◽  
Clearance Kinetics ◽  
Kinetics Of

The lung clearance kinetics of 57Co3O4 in rats of various ages

1991 ◽  
Vol 22 (4) ◽  
pp. 537-549 ◽  
Author(s):  
C.G. Collier ◽  
A. Hodgson ◽  
S.A. Gray ◽  
J.C. Moody ◽  
A. Ball
Keyword(s):  
Lung Clearance ◽  
Clearance Kinetics ◽  
Kinetics Of

IgA nephropathy: clearance kinetics of IgA-containing immune complexes

2018 ◽  
Vol 40 (6) ◽  
pp. 539-543 ◽  
Author(s):  
Ann Chen ◽  
Sung-Sen Yang ◽  
Tsai-Jung Lin ◽  
Shuk-Man Ka
Keyword(s):  
Iga Nephropathy ◽  
Immune Complexes ◽  
Clearance Kinetics ◽  
Kinetics Of

scholarly journals Ca2+-Dependent, Stimulus-Specific Modulation of the Plasma Membrane Ca2+ Pump in Hippocampal Neurons

2009 ◽  
Vol 101 (5) ◽  
pp. 2563-2571 ◽  
Author(s):  
Michael J. Ferragamo ◽  
Jessica L. Reinardy ◽  
Stanley A. Thayer
Keyword(s):  
Plasma Membrane ◽  
Neuronal Activity ◽  
Action Potentials ◽  
Hippocampal Neurons ◽  
Cyclopiazonic Acid ◽  
Synaptic Activity ◽  
Voltage Gated ◽  
Clearance Kinetics ◽  
Transient Elevation ◽  
Kinetics Of

The plasma membrane Ca2+ ATPase (PMCA) plays a major role in restoring Ca2+ to basal levels following transient elevation by neuronal activity. Here we examined the effects of various stimuli that increase [Ca2+]i on PMCA-mediated Ca2+ clearance from hippocampal neurons. We used indo-1-based microfluorimetry in the presence of cyclopiazonic acid to study the rate of PMCA-mediated recovery of Ca2+ elevated by a brief train of action potentials. [Ca2+]i recovery was described by an exponential decay and the time constant provided an index of PMCA-mediated Ca2+ clearance. PMCA function was assessed before and for ≥60 min following a 10-min priming stimulus of either 100 μM N-methyl-d-aspartate (NMDA), 0.1 mM Mg2+ (reduced extracellular Mg2+ induces intense excitatory synaptic activity), 30 mM K+, or control buffer. Recovery kinetics slowed progressively following priming with NMDA or 0.1 mM Mg2+; in contrast, Ca2+ clearance initially accelerated and then slowly returned to initial rates following priming with 30 mM K+-induced depolarization. Treatment with 10 μM calpeptin, an inhibitor of the Ca2+ activated protease calpain, prevented the slowing of kinetics observed following treatment with NMDA but had no affect on the recovery kinetics of control cells. Calpeptin also blocked the rapid acceleration of Ca2+ clearance following depolarization. In calpeptin-treated cells, 0.1 mM Mg2+ induced a graded acceleration of Ca2+ clearance. Thus in spite of producing comparable increases in [Ca2+]i, activation of NMDA receptors, depolarization-induced activation of voltage-gated Ca2+ channels and excitatory synaptic activity each uniquely affected Ca2+ clearance kinetics mediated by the PMCA.

Fluoride bioavailability in saliva using DENTTABS® compared to dentifrice

Open Medicine ◽  
2010 ◽  
Vol 5 (3) ◽  
pp. 375-380 ◽  
Author(s):  
Ella Naumova ◽  
Wolfgang Arnold ◽  
Peter Gaengler
Keyword(s):  
Statistical Analysis ◽  
Flow Rate ◽  
Oral Hygiene ◽  
Salivary Flow ◽  
Spearman Correlation ◽  
Sample Collection ◽  
Amine Fluoride ◽  
Clearance Kinetics ◽  
Kinetics Of ◽  
Baseline Sample

AbstractIt was the aim of this study to assess fluoride retained in saliva after use of fluoride-containing tablet DENTTABS® compared to toothpaste containing amine fluoride. Four subjects (2 normal saliva secretors, 1 slow secretor, and 1 fast secretor) participated in this crossover study comparing DENTTABS® and ELMEX®. After baseline sample collection, calibrated study personnel brushed the subjects’ teeth with the assigned product for 3 minutes. Saliva samples were taken at baseline (T0), immediately after brushing (T1) and then 10 (T2), 25 (T3) and 85 (T4) minutes post-brushing. The amount of saliva collected was measured, and the fluoride content was analysed. All 4 subjects repeated all study cycles 5 times. Statistical analysis was done using the Mann-Whitney-U test and Spearman correlation. The fluoride retention was significantly higher after brushing with DENTTABS® at T1 and T2. There was a correlation between individual salivary flow rate and the F- content. Flow rate in g/min ranged from 1.1 to 3.8 at T1 and from 0.2 to 1.1 at T4 with much higher F- retention in slow secreting cycles. The saliva fluoride clearance kinetics of two equal amounts of fluoride-containing oral hygiene products demonstrate higher retention for DENTTABS®.

Clearance Kinetics of Biomaterials Affects Stem Cell Retention and Therapeutic Efficacy

2014 ◽  
Vol 15 (2) ◽  
pp. 564-573 ◽  
Author(s):  
Chia Y. Lai ◽  
Pei J. Wu ◽  
Steve R. Roffler ◽  
Sho T. Lee ◽  
Shiaw M. Hwang ◽  
...  
Keyword(s):  
Stem Cell ◽  
Therapeutic Efficacy ◽  
Cell Retention ◽  
Clearance Kinetics ◽  
Kinetics Of

scholarly journals Clearance kinetics of the VGF-derived neuropeptide TLQP-21

Neuropeptides ◽  
2018 ◽  
Vol 71 ◽  
pp. 97-103 ◽  
Author(s):  
ZengKui Guo ◽  
Bhavani S. Sahu ◽  
Rongjun He ◽  
Brian Finan ◽  
Cheryl Cero ◽  
...  
Keyword(s):  
Clearance Kinetics ◽  
Kinetics Of
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